Oxidative Stress Alters Creatine Kinase System in Serum and Brain Regions of Polychlorinated Biphenyl (Aroclor 1254)-Exposed Rats: Protective Role of Melatonin

2009 ◽  
Vol 105 (2) ◽  
pp. 92-97 ◽  
Author(s):  
Prabhu Venkataraman ◽  
Gunasekaran Krishnamoorthy ◽  
Kandaswamy Selvakumar ◽  
Jagadeesan Arunakaran
Keyword(s):  
Oxidative Stress ◽  
Creatine Kinase ◽  
Polychlorinated Biphenyl ◽  
Brain Regions ◽  
Protective Role ◽  
Aroclor 1254

Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: Protective role of α-tocopherol

2007 ◽  
Vol 61 (7) ◽  
pp. 435-440 ◽  
Author(s):  
N. Sridevi ◽  
P. Venkataraman ◽  
K. Senthilkumar ◽  
G. Krishnamoorthy ◽  
J. Arunakaran
Keyword(s):  
Oxidative Stress ◽  
Brain Regions ◽  
Protective Role ◽  
Aroclor 1254 ◽  
Membrane Bound

Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid

2012 ◽  
Vol 26 (6) ◽  
pp. 841-848 ◽  
Author(s):  
Jing Liu ◽  
Erqun Song ◽  
Lichao Liu ◽  
Xiaoyan Ma ◽  
Xingguo Tian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hepg2 Cells ◽  
Polychlorinated Biphenyl ◽  
Protective Role ◽  
Dihydrolipoic Acid

Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats

2012 ◽  
Vol 26 (12) ◽  
pp. 522-532 ◽  
Author(s):  
Suganya Sekaran ◽  
Selvakumar Kandaswamy ◽  
Krishnamoorthy Gunasekaran ◽  
Elumalai Perumal ◽  
Fariya Yasmine Afsar Basha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polychlorinated Biphenyls ◽  
Adult Male ◽  
Protective Role ◽  
Male Rats ◽  
Aroclor 1254

Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells

2005 ◽  
Vol 39 (11) ◽  
pp. 1259-1272 ◽  
Author(s):  
Palaniappan Murugesan ◽  
Thirupathi Muthusamy ◽  
Karundevi Balasubramanian ◽  
Jagadeesan Arunakaran
Keyword(s):  
Vitamin C ◽  
Oxidative Damage ◽  
Leydig Cells ◽  
Polychlorinated Biphenyl ◽  
Protective Role ◽  
Aroclor 1254

PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: Protective role of ascorbic acid

2007 ◽  
Vol 28 (3) ◽  
pp. 490-498 ◽  
Author(s):  
Prabhu Venkataraman ◽  
Raju Muthuvel ◽  
Gunasekaran Krishnamoorthy ◽  
Arumugam Arunkumar ◽  
Muthusami Sridhar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Oxidative Damage ◽  
Rat Brain ◽  
Brain Regions ◽  
Protective Role ◽  
Aroclor 1254 ◽  
Rat Brain Regions

scholarly journals Protective Role of Glutathione in the Hippocampus after Brain Ischemia

2021 ◽  
Vol 22 (15) ◽  
pp. 7765
Author(s):  
Youichirou Higashi ◽  
Takaaki Aratake ◽  
Takahiro Shimizu ◽  
Shogo Shimizu ◽  
Motoaki Saito
Keyword(s):  
Oxidative Stress ◽  
Neuronal Death ◽  
Excitatory Amino Acid ◽  
Ischemia Reperfusion ◽  
Thiol Group ◽  
Protective Role ◽  
Key Factor ◽  
Rate Limiting ◽  
Cysteine Uptake

Stroke is a major cause of death worldwide, leading to serious disability. Post-ischemic injury, especially in the cerebral ischemia-prone hippocampus, is a serious problem, as it contributes to vascular dementia. Many studies have shown that in the hippocampus, ischemia/reperfusion induces neuronal death through oxidative stress and neuronal zinc (Zn2+) dyshomeostasis. Glutathione (GSH) plays an important role in protecting neurons against oxidative stress as a major intracellular antioxidant. In addition, the thiol group of GSH can function as a principal Zn2+ chelator for the maintenance of Zn2+ homeostasis in neurons. These lines of evidence suggest that neuronal GSH levels could be a key factor in post-stroke neuronal survival. In neurons, excitatory amino acid carrier 1 (EAAC1) is involved in the influx of cysteine, and intracellular cysteine is the rate-limiting substrate for the synthesis of GSH. Recently, several studies have indicated that cysteine uptake through EAAC1 suppresses ischemia-induced neuronal death via the promotion of hippocampal GSH synthesis in ischemic animal models. In this article, we aimed to review and describe the role of GSH in hippocampal neuroprotection after ischemia/reperfusion, focusing on EAAC1.

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