Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment

2020 ◽  
Vol 79 ◽  
pp. 200-208 ◽  
Author(s):  
Masoomeh Nazifi ◽  
Manoochehr Ashrafpoor ◽  
Shahrbanoo Oryan ◽  
Delaram Eslimi Esfahani ◽  
Ali Akbar Moghadamnia
Keyword(s):  
Synaptic Plasticity ◽  
Synaptic Transmission ◽  
Rat Model ◽  
Memory Impairment ◽  
High Dose ◽  
Neurotoxic Effects

An investigation of possible neurotoxic effects of intrathecal melatonin combined with fentanyl in a rat model

2007 ◽  
Vol 24 (Supplement 39) ◽  
pp. 109
Author(s):  
Z. Fanous ◽  
S. Stoleru ◽  
Z. Haitov ◽  
M. Chanimov ◽  
M. Bahar
Keyword(s):  
Rat Model ◽  
Neurotoxic Effects

P.1.j.018 Deletion of cannabinoid-2 receptors induces memory impairment associated with synaptic plasticity alterations

2013 ◽  
Vol 23 ◽  
pp. S291-S292
Author(s):  
M. García-Gutiérrez ◽  
A. Ortega-Alvaro ◽  
A. Busquets ◽  
J.M. Péirez-Ortiz ◽  
L. Caltana ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Memory Impairment

P.1.27 Functional and molecular correlates of synaptic plasticity in a gene–environment combination rat model of depression

2007 ◽  
Vol 17 ◽  
pp. S24
Author(s):  
L. Musazzi ◽  
V.S. Barbiero ◽  
A. Mallei ◽  
A. Mathè ◽  
A. El Khoury ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Rat Model ◽  
Gene Environment

Mechanism of Traditional Medicine Tongfeng Li’an Granules on Hyperuricemic Rats Based on Regulating Uric Acid Transporter

2021 ◽  
Vol 15 (4) ◽  
pp. 536-541
Author(s):  
Xiangpei Zhao ◽  
Li Li ◽  
Chuanmei Zhong ◽  
Hongli Teng ◽  
Guodong Huang
Keyword(s):  
Uric Acid ◽  
Oral Administration ◽  
Natural Product ◽  
Serum Uric Acid ◽  
Rat Model ◽  
Regulatory Mechanism ◽  
High Dose ◽  
Model Group ◽  
Serum Biochemical ◽  
Acid Transporter

Hyperuricemia (HUA) is a metabolic disorder of purine metabolism which leads to the increase of serum uric acid. Tongfeng Lian granule (TFLA) is a clinical empirical traditional herb prescription in China, is biobased natural product material. To study its regulatory mechanism on uric acid transporter in rats with HUA, the rat model of hyperuricemic was established by oral administration of potassium oxazinate (1.5 g/kg) and adenine (0.05 g/kg). The related indexes were detected to evaluate the uric Acid Transporter after treat with TFLA. In the results, compared with model group, the high dose TFLA can reduce the levels of Related serum biochemical indexes (*P < 0.05, **P < 0.01). TFLA could reduce the levels of URAT1, GLUT9 and increase the expression of OAT3 in kidney. In conclusion, TFLA can effectively inhibit the level of serum uric acid with hyperuricemia rats, and the possible mechanism related to TFLA inhibiting the reabsorption of uric acid by URAT1 and GLUT9, promoting the secretion of OAT3 and uric acid into urine.

Ameliorative effect of sansoninto on sleep disturbance and spatial memory impairment in an Alzheimer's disease rat model

2017 ◽  
Vol 4 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Hiroshi Moriyama ◽  
Takuya Watanabe ◽  
Kotaro Takasaki ◽  
Masaki Nagao ◽  
Kaori Kubota ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spatial Memory ◽  
Sleep Disturbance ◽  
Rat Model ◽  
Memory Impairment ◽  
Ameliorative Effect
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