Head size may modify the impact of white matter lesions on dementia

2012 ◽  
Vol 33 (7) ◽  
pp. 1186-1193 ◽  
Author(s):  
Ingmar Skoog ◽  
Pernille J. Olesen ◽  
Kaj Blennow ◽  
Bo Palmertz ◽  
Sterling C. Johnson ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Head Size ◽  
The Impact

P1-264: Head size and dementia in 85-year-olds. Interaction with white matter lesions

2006 ◽  
Vol 2 ◽  
pp. S173-S174
Author(s):  
Ingmar Skoog ◽  
Kaj Blennow ◽  
Bo Palmertz ◽  
Sterling C. Johnson ◽  
Erin D. Bigler
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Head Size

scholarly journals Education Modulates the Impact of White Matter Lesions on the Risk of Mild Cognitive Impairment and Dementia

2014 ◽  
Vol 22 (11) ◽  
pp. 1336-1345 ◽  
Author(s):  
Marion Mortamais ◽  
Florence Portet ◽  
Adam M. Brickman ◽  
Frank A. Provenzano ◽  
Jordan Muraskin ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
White Matter Lesions ◽  
The Impact

scholarly journals The impact of periventricular white matter lesions in patients with bipolar disorder type I

CNS Spectrums ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Gianluca Serafini ◽  
Maurizio Pompili ◽  
Marco Innamorati ◽  
Nicoletta Girardi ◽  
Leonardo Strusi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Rating Scale ◽  
Brain Magnetic Resonance Imaging ◽  
White Matter Lesions ◽  
Periventricular White Matter ◽  
Type I ◽  
Young Mania ◽  
Affective Symptoms ◽  
The Impact

IntroductionWhite matter hyperintensities (WMHs) are one the most common neuroimaging findings in patients with bipolar disorder (BD). It has been suggested that WMHs are associated with impaired insight in schizophrenia and schizoaffective patients; however, the relationship between insight and WMHs in BD type I has not been directly investigated.MethodsPatients with BD-I (148) were recruited and underwent brain magnetic resonance imaging (MRI). Affective symptoms were assessed using Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale (HDRS17); the presence of impaired insight was based on the corresponding items of YMRS and HDRS17.ResultsMultiple punctate periventricular WMHs (PWMHs) and deep WMHs (DWMHs) were observed in 49.3% and 39.9% of the cases, respectively. Subjects with lower insight for mania had significantly more PWMHs (54.6% vs 22.2%; p < 0.05) when compared to BD-I patients with higher insight for mania. The presence of PWMHs was independently associated with lower insight for mania: patients who denied illness according to the YMRS were 4 times more likely to have PWMHs (95% CI: 1.21/13.42) than other patients.ConclusionsImpaired insight in BD-I is associated with periventricular WMHs. The early identification of BD-I subjects with PWMHs and impaired insight may be crucial for clinicians.

P2-476: RESERVE AS FUNCTIONAL CONNECTIVITY (IN COGNITIVE CONTROL NETWORKS) MODERATES THE IMPACT OF WHITE MATTER LESIONS IN AGING

2006 ◽  
Vol 14 (7S_Part_16) ◽  
pp. P907-P907
Author(s):  
Gloria Benson ◽  
Andrea Hildebrandt ◽  
Catharina Lange ◽  
Theresa Köbe ◽  
Claudia Schwarz ◽  
...  
Keyword(s):  
White Matter ◽  
Functional Connectivity ◽  
Cognitive Control ◽  
White Matter Lesions ◽  
Control Networks ◽  
The Impact

scholarly journals Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes

2010 ◽  
Vol 32 (1) ◽  
pp. 223-228 ◽  
Author(s):  
Declan T. Chard ◽  
Jonathan S. Jackson ◽  
David H. Miller ◽  
Claudia A.M. Wheeler-Kingshott
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
The Impact

scholarly journals Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults

Stroke ◽  
2021 ◽  
Author(s):  
Keun-Hwa Jung ◽  
Kimberly A. Stephens ◽  
Kathryn M. Yochim ◽  
Joost M. Riphagen ◽  
Chan Mi Kim ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Lesions ◽  
Class Ii ◽  
Class I ◽  
Cerebral White Matter ◽  
Imaging Features ◽  
Volume Number ◽  
Human Connectome Project ◽  
Cerebral White Matter Lesions ◽  
The Impact

Background and Purpose: Cerebral white matter signal abnormalities (WMSAs) are a significant radiological marker associated with brain and vascular aging. However, understanding their clinical impact is limited because of their pathobiological heterogeneity. We determined whether use of robust reliable automated procedures can distinguish WMSA classes with different clinical consequences. Methods: Data from generally healthy participants aged >50 years with moderate or greater WMSA were selected from the Human Connectome Project-Aging (n=130). WMSAs were segmented on T1 imaging. Features extracted from WMSA included total and regional volume, number of discontinuous clusters, size of noncontiguous lesion, contrast of lesion intensity relative to surrounding normal appearing tissue using a fully automated procedure. Hierarchical clustering was used to classify individuals into distinct classes of WMSA. Radiological and clinical variability was evaluated across the individual WMSA classes. Results: Class I was characterized by multiple, small, lower-contrast lesions predominantly in the deep WM; class II by large, confluent lesions in the periventricular WM; and class III by higher-contrast lesions restricted to the juxtaventricular WM. Class II was associated with lower myelin content than the other 2 classes. Class II was more prevalent in older subjects and was associated with a higher prevalence of hypertension and lower physical activity levels. Poor sleep quality was associated with a greater risk of class I. Conclusions: We classified heterogeneous subsets of cerebral white matter lesions into distinct classes that have different clinical risk factors. This new method for identifying classes of WMSA will be important in understanding the underlying pathophysiology and in determining the impact on clinical outcomes.

scholarly journals Tissue plasminogen activator prevents white matter damage following stroke

2011 ◽  
Vol 208 (6) ◽  
pp. 1229-1242 ◽  
Author(s):  
Fernando Correa ◽  
Maxime Gauberti ◽  
Jérôme Parcq ◽  
Richard Macrez ◽  
Yannick Hommet ◽  
...  
Keyword(s):  
White Matter ◽  
Plasminogen Activator ◽  
Cell Fate ◽  
Tissue Plasminogen Activator ◽  
Mechanism Of Action ◽  
White Matter Lesions ◽  
Brain Diseases ◽  
Stroke Treatment ◽  
Tissue Plasminogen ◽  
The Impact

Tissue plasminogen activator (tPA) is the only available treatment for acute stroke. In addition to its vascular fibrinolytic action, tPA exerts various effects within the brain, ranging from synaptic plasticity to control of cell fate. To date, the influence of tPA in the ischemic brain has only been investigated on neuronal, microglial, and endothelial fate. We addressed the mechanism of action of tPA on oligodendrocyte (OL) survival and on the extent of white matter lesions in stroke. We also investigated the impact of aging on these processes. We observed that, in parallel to reduced levels of tPA in OLs, white matter gets more susceptible to ischemia in old mice. Interestingly, tPA protects murine and human OLs from apoptosis through an unexpected cytokine-like effect by the virtue of its epidermal growth factor–like domain. When injected into aged animals, tPA, although toxic to the gray matter, rescues white matter from ischemia independently of its proteolytic activity. These studies reveal a novel mechanism of action of tPA and unveil OL as a target cell for cytokine effects of tPA in brain diseases. They show overall that tPA protects white matter from stroke-induced lesions, an effect which may contribute to the global benefit of tPA-based stroke treatment.

scholarly journals Evaluating and reducing the impact of white matter lesions on brain volume measurements

2011 ◽  
Vol 33 (9) ◽  
pp. 2062-2071 ◽  
Author(s):  
Marco Battaglini ◽  
Mark Jenkinson ◽  
Nicola De Stefano
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Volume Measurements ◽  
The Impact

Cognitive reserve lessens the burden of white matter lesions on executive functions in bipolar disorder

2016 ◽  
Vol 46 (15) ◽  
pp. 3095-3104 ◽  
Author(s):  
S. Rolstad ◽  
C. Abé ◽  
E. Olsson ◽  
C. Eckerström ◽  
M. Landén
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Executive Functions ◽  
Cognitive Reserve ◽  
White Matter Lesions ◽  
Brain Pathology ◽  
Linear Regression Models ◽  
Brain Volumes ◽  
Interaction Terms ◽  
The Impact

BackgroundThe concept of cognitive reserve (CR) hypothesizes that intellectually stimulating activities provide resilience against brain pathology/disease. Whereas brain abnormalities and cognitive impairment are frequently reported in bipolar disorder (BD), it is unknown whether the impact of brain alterations can be lessened by higher CR in BD.MethodWe tested if higher CR would reduce the influence of total volumes of deep white matter hypointensities (WMH), ventricular cerebrospinal fluid (CSF), and prefrontal cortex on memory, executive, and attention/speed functions in patients with BD (n = 75). Linear regression models with interaction terms for CR and brain volumes were applied to directly test if CR reduces the influence of brain pathology on cognitive domains.ResultsCR reduced the influence of total volumes of deep WMH (β = −0.38, Q = 0.003) and ventricular CSF (β = −41, Q = 006) on executive functions.ConclusionsThe interactions between CR and total volumes of deep WMH/ventricular CSF appear to account for executive functioning in BD. The results suggest that the concept of CR is applicable in BD. Higher reserve capacity in BD alters the relationship between brain pathology and clinical presentation.

Sign in / Sign up

Export Citation Format

Share Document