The hormone therapy, Premarin, impairs hippocampus-dependent spatial learning and memory and reduces activation of new granule neurons in response to memory in female rats

2013 ◽  
Vol 34 (3) ◽  
pp. 986-1004 ◽  
Author(s):  
Cindy K. Barha ◽  
Liisa A.M. Galea
Keyword(s):  
Hormone Therapy ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Female Rats ◽  
Spatial Learning And Memory ◽  
Granule Neurons

scholarly journals Sex differences in spatial learning and memory and hippocampal long-term potentiation at perforant pathway-dentate gyrus (PP-DG) synapses in Wistar rats

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Samaneh Safari ◽  
Nesa Ahmadi ◽  
Reihaneh Mohammadkhani ◽  
Reza Ghahremani ◽  
Maryam Khajvand-Abedeni ◽  
...  
Keyword(s):  
Sex Differences ◽  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Long Term Potentiation ◽  
Female Rats ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Term Potentiation

Abstract Background Recent studies show that gender may have a significant impact on brain functions. However, the reports of sex effects on spatial ability and synaptic plasticity in rodents are divergent and controversial. Here spatial learning and memory was measured in male and female rats by using Morris water maze (MWM) task. Moreover, to assess sex difference in hippocampal synaptic plasticity we examined hippocampal long-term potentiation (LTP) at perforant pathway-dentate gyrus (PP-DG) synapses. Results In MWM task, male rats outperformed female rats, as they had significantly shorter swim distance and escape latency to find the hidden platform during training days. During spatial reference memory test, female rats spent less time and traveled less distance in the target zone. Male rats also had larger LTP at PP-DG synapses, which was evident in the high magnitude of population spike (PS) potentiation and the field excitatory post synaptic potentials (fEPSP) slope. Conclusions Taken together, our results suggest that sex differences in the LTP at PP-DG synapses, possibly contribute to the observed sex difference in spatial learning and memory.

Diphenyl diselenide diet intake improves spatial learning and memory deficits in hypothyroid female rats

2012 ◽  
Vol 30 (2) ◽  
pp. 83-89 ◽  
Author(s):  
Glaecir Roseni Mundstock Dias ◽  
Francielli Araújo Vieira ◽  
Fernando Dobrachinski ◽  
Jéssika Cristina Bridi ◽  
Rodrigo de Souza Balk ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Deficits ◽  
Female Rats ◽  
Spatial Learning And Memory ◽  
Diphenyl Diselenide ◽  
Learning And Memory Deficits ◽  
Diet Intake
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