scholarly journals Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

2013 ◽  
Vol 34 (8) ◽  
pp. 2003-2013 ◽  
Author(s):  
Lies Clerx ◽  
Ineke A. van Rossum ◽  
Leah Burns ◽  
Dirk L. Knol ◽  
Philip Scheltens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease

2017 ◽  
Vol 44 (1-2) ◽  
pp. 12-24 ◽  
Author(s):  
Karin Persson ◽  
Maria Lage Barca ◽  
Rannveig Sakshaug Eldholm ◽  
Lena Cavallin ◽  
Jūratė Šaltytė Benth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Delayed Recall ◽  
Medial Temporal Lobe Atrophy ◽  
Adjusted Model ◽  
Lobe Atrophy

Background/Aims: To evaluate whether visual assessment of medial temporal lobe atrophy (vaMTA) can predict 2-year conversion from mild cognitive impairment (MCI) to dementia and progression of MCI and Alzheimer's disease dementia as measured by the Clinical Dementia Rating Scale Sum of Boxes score (CDR-SB). Methods: vaMTA was performed in 94 patients with MCI according to the Winblad criteria and in 124 patients with AD according to ICD-10 and NINCDS-ADRDA criteria. Demographic data, the Consortium to Establish a Registry for Alzheimer's Disease 10-word delayed recall, APOE ɛ4 status, Cornell Scale for Depression in Dementia, and comorbid hypertension were used as covariates. Results: vaMTA was associated with MCI conversion in an unadjusted model but not in an adjusted model (p = 0.075), where delayed recall and APOE ɛ4 status were significant predictors. With CDR-SB change as the outcome, an interaction between vaMTA and diagnosis was found, but in the adjusted model only delayed recall and age were significant predictors. For vaMTA below 2, the association between vaMTA and CDR-SB change differed between diagnostic groups. Similar results were found based on a trajectory analysis. Conclusion: In adjusted models, memory function, APOE ɛ4 status and age were significant predictors of disease progression, not vaMTA. The association between vaMTA and CDR-SB change was different in patients with MCI and Alzheimer's disease dementia.

Correlation of medial temporal lobe atrophy with seizures in Alzheimer’s disease and mild cognitive impairment: A case control study

2017 ◽  
Vol 04 (02) ◽  
pp. 132-135
Author(s):  
Vikas Dhikav ◽  
Sharmila Duraisawmy ◽  
Kuljeet Anand
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Care Hospital ◽  
Medial Temporal Lobe Atrophy ◽  
Dementia Of Alzheimer’S Type ◽  
Lobe Atrophy

Abstract Background Seizures are common accompaniment of neurodegenerative disease. Though, Alzheimer’s disease (AD) is the most common cause, but seizures also occasionally occur in mild cognitive impairment (MCI). Material & methods We studied patients of Subjective Memory Complaints coming to the Department of Neurology of a Tertiary Care Hospital in Northern India from July 2012 to July 2015. A total of 171 patients were studied. Those with a diagnosis of AD/MCI with seizures were taken for the current study. A total of 30 controls with chronic diseases were taken for comparison. Medial Temporal Lobe Atrophy (MTA) Rating was done using Sheleten’s Visual Rating Scale. Results A total of 256 patients were screened and 171 had dementia of Alzheimer’s type (n = 75; M:F = 60:15) and 96 patients had MCI (M:F = 76:20). The mean MMSE of those with AD was 18.5 ± 3.3 was and that of the MCI was 26.6 ± 2.4. A total of 9 cases with AD had seizures and 6 had seizures in MCI group (total n = 15). Moderately strong correlation was obtained between MMSE of AD patients having seizures and MTA scoring. Conclusions Seizures are common in dementia of Alzheimer’s type and not uncommon in MCI. They have the potential to worsen the cognitive profile of the patient and need attention in these patients.

Medial temporal lobe atrophy, but not CSF biomarkers, correlates with cognitive impairment in Alzheimer's disease

2021 ◽  
Vol 429 ◽  
pp. 119059
Author(s):  
Edoardo Barvas ◽  
Chiara Monaldini ◽  
Roberto Frusciante ◽  
Mirco Volpini ◽  
Beatrice Viti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Csf Biomarkers ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals Basal Serum Cortisol Levels, Depression And Medial Temporal Lobe Atrophy In Patients With Mild Cognitive Impairment And Alzheimer’s Disease

2015 ◽  
Vol 1 (1) ◽  
pp. 25-30
Author(s):  
Vikas Dhikav ◽  
Lokesh Sharma ◽  
Pinki Mishra ◽  
Neera Sharma ◽  
Kuljeet Singh Anand ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Serum Cortisol ◽  
Medial Temporal Lobe Atrophy ◽  
Basal Serum ◽  
Cortisol Levels ◽  
Lobe Atrophy

scholarly journals Atrophy and cognitive profiles in older adults with temporal lobe epilepsy are similar to mild cognitive impairment

Brain ◽  
2020 ◽  
Author(s):  
Erik Kaestner ◽  
Anny Reyes ◽  
Austin Chen ◽  
Jun Rao ◽  
Anna Christina Macari ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Late Onset ◽  
Amnestic Mild Cognitive Impairment

Abstract Epilepsy incidence and prevalence peaks in older adults yet systematic studies of brain ageing and cognition in older adults with epilepsy remain limited. Here, we characterize patterns of cortical atrophy and cognitive impairment in 73 older adults with temporal lobe epilepsy (>55 years) and compare these patterns to those observed in 70 healthy controls and 79 patients with amnestic mild cognitive impairment, the prodromal stage of Alzheimer’s disease. Patients with temporal lobe epilepsy were recruited from four tertiary epilepsy surgical centres; amnestic mild cognitive impairment and control subjects were obtained from the Alzheimer’s Disease Neuroimaging Initiative database. Whole brain and region of interest analyses were conducted between patient groups and controls, as well as between temporal lobe epilepsy patients with early-onset (age of onset <50 years) and late-onset (>50 years) seizures. Older adults with temporal lobe epilepsy demonstrated a similar pattern and magnitude of medial temporal lobe atrophy to amnestic mild cognitive impairment. Region of interest analyses revealed pronounced medial temporal lobe thinning in both patient groups in bilateral entorhinal, temporal pole, and fusiform regions (all P < 0.05). Patients with temporal lobe epilepsy demonstrated thinner left entorhinal cortex compared to amnestic mild cognitive impairment (P = 0.02). Patients with late-onset temporal lobe epilepsy had a more consistent pattern of cortical thinning than patients with early-onset epilepsy, demonstrating decreased cortical thickness extending into the bilateral fusiform (both P < 0.01). Both temporal lobe epilepsy and amnestic mild cognitive impairment groups showed significant memory and language impairment relative to healthy control subjects. However, despite similar performances in language and memory encoding, patients with amnestic mild cognitive impairment demonstrated poorer delayed memory performances relative to both early and late-onset temporal lobe epilepsy. Medial temporal lobe atrophy and cognitive impairment overlap between older adults with temporal lobe epilepsy and amnestic mild cognitive impairment highlights the risks of growing old with epilepsy. Concerns regarding accelerated ageing and Alzheimer’s disease co-morbidity in older adults with temporal lobe epilepsy suggests an urgent need for translational research aimed at identifying common mechanisms and/or targeting symptoms shared across a broad neurological disease spectrum.

scholarly journals Association between medial temporal lobe atrophy on CT and parietotemporal uptake decrease on SPECT in Alzheimer's disease

1997 ◽  
Vol 63 (4) ◽  
pp. 441-445 ◽  
Author(s):  
I. Lavenu ◽  
F. Pasquier ◽  
F. Lebert ◽  
B. Jacob ◽  
H. Petit
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy
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