Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer’s disease

2015 ◽  
Vol 36 (10) ◽  
pp. 2768-2784 ◽  
Author(s):  
Amar Jyoti ◽  
Andrea Plano ◽  
Gernot Riedel ◽  
Bettina Platt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer’s disease

2019 ◽  
Vol 362 ◽  
pp. 160-172 ◽  
Author(s):  
Filip Kosel ◽  
Paula Torres Munoz ◽  
J. Renee Yang ◽  
Aimee A. Wong ◽  
Tamara B. Franklin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Age Related ◽  
5Xfad Mouse ◽  
Age Related Changes ◽  
Social Behaviours

scholarly journals Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease

2011 ◽  
Vol 216 (3) ◽  
pp. 227-237 ◽  
Author(s):  
Marijke A. M. Lemmens ◽  
Annerieke S. R. Sierksma ◽  
Bart P. F. Rutten ◽  
Frank Dennissen ◽  
Harry W. M. Steinbusch ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Frontal Cortex ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Age Related ◽  
Age Related Changes

scholarly journals Sex-specific interactions between procedural and deliberative decision-making systems in a mouse model of Alzheimer’s disease

2021 ◽  
Author(s):  
Rachel Anderson ◽  
Damyan W. Hart ◽  
Brian Sweis ◽  
Mathew A. Sherman ◽  
Mark J. Thomas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Decision Making ◽  
Mouse Model ◽  
Neural Substrates ◽  
Behavioral Changes ◽  
Model Of Alzheimer’S Disease ◽  
Age Related ◽  
Accurate Picture ◽  
And Control

AbstractA central question in aging and Alzheimer’s disease (AD) is when and how neural substrates underlying decision-making are altered. Here we show that while APP mice, a commonly used mouse model of AD, were able to learn Restaurant Row, a complex neuroeconomic decision-making task, they were significantly impaired in procedural, habit-forming, aspects of cognition and relied heavily on deliberation when making decisions. Surprisingly, these behavioral changes are associated with amyloid-beta (Aβ) pathology and network remodeling in the striatum, a key brain region involved in procedural cognition. Furthermore, APP mice and control mice relied on distinct sex-specific strategies in this neuroeconomic task. These findings provide foundational pillars to examine how aging and age-related neurodegenerative diseases impact decision-making across sexes. They also highlight the need for complex behavioral tasks that allow for the dissociation of competing neurally-distinct decision-making circuits to get an accurate picture of changes in neurodegenerative models of human disease.

[P1-135]: DEPRESSION IN A PRECLINICAL MOUSE MODEL OF ALZHEIMER's DISEASE: AN AGE-RELATED HEDONIC DEFICIT

2017 ◽  
Vol 13 (7S_Part_6) ◽  
pp. P293-P294
Author(s):  
Adam Brelsford ◽  
Jasmine Clarkson ◽  
Jessica Hall ◽  
Emma J. Kidd ◽  
Rhian S. Thomas ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Age Related
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