Association between triallelic polymorphism of the serotonin transporter and [18F]MPPF binding potential at 5-HT1A receptors in healthy subjects

NeuroImage ◽  
2009 ◽  
Vol 47 (2) ◽  
pp. 482-492 ◽  
Author(s):  
Amélie Lothe ◽  
Claudette Boni ◽  
Nicolas Costes ◽  
Philip Gorwood ◽  
Sandrine Bouvard ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Healthy Subjects ◽  
Binding Potential

FC10-05 - Attenuated serotonin transporter association between midbrain and nucleus accumbens in major depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 1868-1868
Author(s):  
A. Hahn ◽  
E. Akimova ◽  
D. Häusler ◽  
C. Philippe ◽  
M. Savli ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Serotonin Transporter ◽  
Healthy Subjects ◽  
Reward Processing ◽  
Binding Potential ◽  
Projection Area ◽  
Reference Tissue ◽  
Hedonic Experience ◽  
Image Position ◽  
First Time

IntroductionPatients suffering from major depressive disorder (MDD) exhibit alterations in serotonin transporter (5-HTT) binding clinically reflected by lack of hedonic experience. We recently demonstrated the importance to evaluate interregional relationships of neurotransmitter systems, providing important complementary information on a network level.ObjectiveTo identify interregional 5-HTT relationships between the midbrain raphe region and projection areas in MDD patients compared to controls.MethodsEighteen medication-free patients with MDD and 16 healthy subjects underwent PET using [11C] DASB. 5-HTT binding potential (BPND) maps were computed with the multilinear-reference-tissue-model-2 in PMOD3.1. Voxel-wise linear regression was calculated in SPM8 using midbrain 5-HTT BPND as regressor; group comparisons were assessed by ANOVA (p < 0.001).ResultsHealthy subjects showed positive associations between serotonin transporters located in the midbrain and transporters expressed in the nucleus accumbens bilaterally. Importantly, this relationship was significantly decreased in MDD patients as compared to controls (t = 5.41/4.84, right/left hemisphere; see figure).ConclusionsThis study demonstrates for the first time 5-HTT alterations on a network level in MDD patients between the midbrain and a major projection area. Our results complement previous findings emphasizing the importance of the nucleus accumbens in MDD and indicate a disturbed serotonergic regulation in this key area of reward processing.

Brain serotonin transporter binding in former users of MDMA (‘ecstasy’)

2009 ◽  
Vol 194 (4) ◽  
pp. 355-359 ◽  
Author(s):  
Sudhakar Selvaraj ◽  
Rosa Hoshi ◽  
Zubin Bhagwagar ◽  
Naga Venkatesha Murthy ◽  
Rainer Hinz ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Experimental Studies ◽  
Public Health Problem ◽  
Brain Regions ◽  
Brain Serotonin ◽  
Binding Potential ◽  
Major Public Health Problem ◽  
Positron Emission ◽  
Significant Difference ◽  
Serotonin Neurons

BackgroundAnimal experimental studies have prompted concerns that widespread use of 3,4-methylenedioxymethamphetamine (MDMA; ‘ecstasy’) by young people may pose a major public health problem in terms of persistent serotonin neurotoxicity.AimsTo determine the status of brain serotonin neurons in a group of abstinent MDMA users.MethodWe assessed the integrity of brain serotonin neurons by measuring serotonin transporter (SERT) binding using positron emission tomography (PET) and [11C]DASB in 12 former MDMA users, 9 polydrug users who had never taken MDMA and 19 controls who reported no history of illicit drug use.ResultsThere was no significant difference in the binding potential of [11C]DASB between the groups in any of the brain regions examined.ConclusionsTo the extent that [11C]DASB binding provides an index of the integrity of serotonin neurons, our findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans.

Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype

2007 ◽  
Vol 114 (5) ◽  
pp. 635-639 ◽  
Author(s):  
M. Reimold ◽  
M. N. Smolka ◽  
G. Schumann ◽  
A. Zimmer ◽  
J. Wrase ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Binding Potential ◽  
Serotonin Transporter Genotype

scholarly journals Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates

2019 ◽  
Vol 116 (29) ◽  
pp. 14761-14768 ◽  
Author(s):  
Andrea M. Santangelo ◽  
Steve J. Sawiak ◽  
Tim Fryer ◽  
Young Hong ◽  
Yoshiro Shiba ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genetic Variation ◽  
Serotonin Transporter ◽  
Critical Role ◽  
Binding Potential ◽  
Repeat Region ◽  
Serotonin 2A Receptor ◽  
Neurochemical Changes ◽  
The Right ◽  
Serotonin 2A

Genetic variation in the serotonin transporter gene (SLC6A4) is associated with vulnerability to affective disorders and pharmacotherapy efficacy. We recently identified sequence polymorphisms in the common marmoset SLC6A4 repeat region (AC/C/G and CT/T/C) associated with individual differences in anxiety-like trait, gene expression, and response to antidepressants. The mechanisms underlying the effects of these polymorphisms are unknown, but a key mediator of serotonin action is the serotonin 2A receptor (5HT2A). Thus, we correlated 5HT2A binding potential (BP) and RNA gene expression in 16 SLC6A4 genotyped marmosets with responsivity to 5HT2A antagonism during the human intruder test of anxiety. Voxel-based analysis and RNA measurements showed a reduction in 5HT2A BP and gene expression specifically in the right posterior insula of individuals homozygous for the anxiety-related variant AC/C/G. These same marmosets displayed an anxiogenic, dose-dependent response to the human intruder after 5HT2A pharmacological antagonism, while CT/T/C individuals showed no effect. A voxel-based correlation analysis, independent of SLC6A4 genotype, revealed that 5HT2A BP in the adjacent right anterior insula and insula proisocortex was negatively correlated with trait anxiety scores. Moreover, 5HT2A BP in both regions was a good predictor of the size and direction of the acute emotional response to the human intruder threat after 5HT2A antagonism. Our findings suggest that genetic variation in the SLC6A4 repeat region may contribute to the trait anxious phenotype via neurochemical changes in brain areas implicated in interoceptive and emotional processing, with a critical role for the right insula 5HT2A in the regulation of affective responses to threat.

In-vivo serotonin transporter availability and somatization in healthy subjects

2016 ◽  
Vol 94 ◽  
pp. 354-359 ◽  
Author(s):  
Anke Bresch ◽  
Michael Rullmann ◽  
Julia Luthardt ◽  
Katrin Arelin ◽  
Georg A. Becker ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Healthy Subjects

Lower Serotonin Transporter Binding Potential in the Human Brain During Major Depressive Episodes

2006 ◽  
Vol 163 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Ramin V. Parsey ◽  
Ramin S. Hastings ◽  
Maria A. Oquendo ◽  
Yung-yu Huang ◽  
Norman Simpson ◽  
...  
Keyword(s):  
Human Brain ◽  
Serotonin Transporter ◽  
Binding Potential ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

scholarly journals Evaluation of dopamine D3 receptor occupancy by blonanserin using [11C]-(+)-PHNO in schizophrenia patients

2020 ◽  
Author(s):  
Takeshi Sakayori ◽  
Amane Tateno ◽  
Ryosuke Arakawa ◽  
Woo-chan Kim ◽  
Yoshiro Okubo
Keyword(s):  
Substantia Nigra ◽  
Globus Pallidus ◽  
Healthy Subjects ◽  
Receptor Occupancy ◽  
Binding Potential ◽  
Positron Emission ◽  
Dopamine D3 ◽  
Continued Use ◽  
Pet Scans ◽  
Average Occupancy

Abstract Rationale Unlike other antipsychotics, our previous positron emission tomography (PET) study demonstrated that a single dose of blonanserin occupied dopamine D3 as well as dopamine D2 receptors in healthy subjects. However, there has been no study concerning the continued use of blonanserin. Objectives We examined D2 and D3 receptor occupancies in patients with schizophrenia who had been treated with blonanserin. Methods Thirteen patients with schizophrenia participated. PET examinations were performed on patients treated with clinical dosage of blonanserin or olanzapine alone. A crossover design was used in which seven patients switched drugs after the first scan, and PET examinations were conducted again. D2 and D3 receptor occupancies were evaluated by [11C]-(+)-PHNO. We used nondisplaceable binding potential (BPND) of 6 healthy subjects which we previously reported as baseline. To consider the effect of upregulation of D3 receptor by continued use of antipsychotics, D3 receptor occupancy by blonanserin in seven subjects who completed 2 PET scans were re-analyzed by using BPND of olanzapine condition as baseline. Results Average occupancy by olanzapine (10.8 ± 6.0 mg/day) was as follows: caudate 32.8 ± 18.3%, putamen 26.3 ± 18.2%, globus pallidus − 33.7 ± 34.9%, substantia nigra − 112.8 ± 90.7%. Average occupancy by blonanserin (12.8 ± 5.6 mg/day) was as follows: caudate 61.0 ± 8.3%, putamen 55.5 ± 9.5%, globus pallidus 48.9 ± 12.4%, substantia nigra 34.0 ± 20.6%. EC50 was 0.30 ng/mL for D2 receptor for caudate and putamen (df = 19, p < 0.0001) and 0.70 ng/mL for D3 receptor for globus pallidus and substantia nigra (df = 19, p < 0.0001). EC50 for D3 receptor of blonanserin changed to 0.22 ng/mL (df = 13, p = 0.0041) when we used BPND of olanzapine condition as baseline. Conclusions Our study confirmed that blonanserin occupied both D2 and D3 receptors in patients with schizophrenia.

Cognitive function is related to fronto-striatal serotonin transporter levels – a brain PET study in young healthy subjects

2010 ◽  
Vol 213 (2-3) ◽  
pp. 573-581 ◽  
Author(s):  
Karine Madsen ◽  
David Erritzoe ◽  
Erik Lykke Mortensen ◽  
Anders Gade ◽  
Jacob Madsen ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Serotonin Transporter ◽  
Healthy Subjects ◽  
Brain Pet

scholarly journals Temperament, character and serotonin activity in the human brain: a positron emission tomography study based on a general population cohort

2012 ◽  
Vol 43 (4) ◽  
pp. 881-894 ◽  
Author(s):  
L. Tuominen ◽  
J. Salo ◽  
J. Hirvonen ◽  
K. Någren ◽  
P. Laine ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Serotonin Transporter ◽  
Population Based ◽  
Emission Tomography ◽  
Brain Serotonin ◽  
Binding Potential ◽  
Positron Emission ◽  
General Population Cohort ◽  
Temperament Dimension

BackgroundThe psychobiological model of personality by Cloninger and colleagues originally hypothesized that interindividual variability in the temperament dimension ‘harm avoidance’ (HA) is explained by differences in the activity of the brain serotonin system. We assessed brain serotonin transporter (5-HTT) density in vivo with positron emission tomography (PET) in healthy individuals with high or low HA scores using an ‘oversampling’ study design.MethodSubjects consistently in either upper or lower quartiles for the HA trait were selected from a population-based cohort in Finland (n = 2075) with pre-existing Temperament and Character Inventory (TCI) scores. A total of 22 subjects free of psychiatric and somatic disorders were included in the matched high- and low-HA groups. The main outcome measure was regional 5-HTT binding potential (BPND) in high- and low-HA groups estimated with PET and [11C]N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine ([11C]MADAM). In secondary analyses, 5-HTT BPND was correlated with other TCI dimensions.Results5-HTT BPND did not differ between high- and low-HA groups in the midbrain or any other brain region. This result remained the same even after adjusting for other relevant TCI dimensions. Higher 5-HTT BPND in the raphe nucleus predicted higher scores in ‘self-directedness’.ConclusionsThis study does not support an association between the temperament dimension HA and serotonin transporter density in healthy subjects. However, we found a link between high serotonin transporter density and high ‘self-directedness’ (ability to adapt and control one's behaviour to fit situations in accord with chosen goals and values). We suggest that biological factors are more important in explaining variability in character than previously thought.

Sign in / Sign up

Export Citation Format

Share Document