scholarly journals Association between heart rate variability and fluctuations in resting-state functional connectivity

NeuroImage ◽  
2013 ◽  
Vol 68 ◽  
pp. 93-104 ◽  
Author(s):  
Catie Chang ◽  
Coraline D. Metzger ◽  
Gary H. Glover ◽  
Jeff H. Duyn ◽  
Hans-Jochen Heinze ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals The Influence of Heart Rate Variability Biofeedback on Cardiac Regulation and Functional Brain Connectivity

2021 ◽  
Vol 15 ◽  
Author(s):  
Andy Schumann ◽  
Feliberto de la Cruz ◽  
Stefanie Köhler ◽  
Lisa Brotte ◽  
Karl-Jürgen Bär
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Functional Connectivity ◽  
Resting State ◽  
Brain Connectivity ◽  
Cingulate Cortex ◽  
Brain Regions ◽  
Control Group ◽  
Functional Brain ◽  
Middle Cingulate Cortex

BackgroundHeart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its impact on brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention on functional brain connectivity in healthy subjects.MethodsHRV biofeedback was carried out in five sessions per week, including four at home and one in our lab. A control group played jump‘n’run games instead of the training. Functional magnetic resonance imaging was conducted before and after the intervention in both groups. To compute resting state functional connectivity (RSFC), we defined regions of interest in the ventral medial prefrontal cortex (VMPFC) and a total of 260 independent anatomical regions for network-based analysis. Changes of RSFC of the VMPFC to other brain regions were compared between groups. Temporal changes of HRV during the resting state recording were correlated to dynamic functional connectivity of the VMPFC.ResultsFirst, we corroborated the role of the VMPFC in cardiac autonomic regulation. We found that temporal changes of HRV were correlated to dynamic changes of prefrontal connectivity, especially to the middle cingulate cortex, the left insula, supplementary motor area, dorsal and ventral lateral prefrontal regions. The biofeedback group showed a drop in heart rate by 5.2 beats/min and an increased SDNN as a measure of HRV by 8.6 ms (18%) after the intervention. Functional connectivity of the VMPFC increased mainly to the insula, the amygdala, the middle cingulate cortex, and lateral prefrontal regions after biofeedback intervention when compared to changes in the control group. Network-based statistic showed that biofeedback had an influence on a broad functional network of brain regions.ConclusionOur results show that increased heart rate variability induced by HRV-biofeedback is accompanied by changes in functional brain connectivity during resting state.

scholarly journals The influence of heart rate variability biofeedback on cardiac regulation and functional brain connectivity

2020 ◽  
Author(s):  
Andy Schumann ◽  
Feliberto de la Cruz ◽  
Stefanie Köhler ◽  
Lisa Brotte ◽  
Karl-Jürgen Bär
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Brain Connectivity ◽  
Brain Regions ◽  
Anterior Insula ◽  
Control Group ◽  
Functional Brain

AbstractBackgroundHeart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its impact on brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention on functional brain connectivity in healthy subjects.MethodsHRV biofeedback was carried out in five sessions per week, including four at home and one in our lab. A control group played jump‘n’run games instead of the training. Functional magnetic resonance imaging was conducted before and after the intervention in both groups. To compute resting state functional connectivity (RSFC), we defined regions of interest in the ventral medial prefrontal cortex (VMPFC) and a total of 260 independent anatomical regions for network-based analysis. Changes of RSFC of the VMPFC to other brain regions were compared between groups. Temporal changes of HRV during the resting state recording were correlated to dynamic functional connectivity of the VMPFC.ResultsFirst, we corroborated the role of the VMPFC in cardiac autonomic regulation. We found that temporal changes of HRV were correlated to dynamic changes of prefrontal connectivity, especially to the middle cingulate cortex, left anterior insula, right amygdala, supplementary motor area, dorsal and ventral lateral prefrontal regions. The biofeedback group showed a drop in heart rate by 5.5 beats/min and an increased RMSSD as a measure of HRV by 10.1ms (33%) after the intervention. Functional connectivity of the VMPFC increased mainly to the right anterior insula, the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex after biofeedback intervention when compared to changes in the control group. Network-based statistic showed that biofeedback had an influence on a broad functional network of brain regions.ConclusionOur results show that increased vagal modulation induced by HRV-biofeedback is accompanied by changes in functional brain connectivity during resting state.

Relating Disinhibited Eating Behaviors to Resting State Functional Connectivity in Young Children

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1889-P
Author(s):  
ALLISON L.B. SHAPIRO ◽  
SUSAN L. JOHNSON ◽  
BRIANNE MOHL ◽  
GRETA WILKENING ◽  
KRISTINA T. LEGGET ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Young Children ◽  
Resting State ◽  
Eating Behaviors ◽  
Resting State Functional Connectivity ◽  
Disinhibited Eating

scholarly journals The effect of congenital blindness on resting-state functional connectivity revisited

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria J. S. Guerreiro ◽  
Madita Linke ◽  
Sunitha Lingareddy ◽  
Ramesh Kekunnaya ◽  
Brigitte Röder
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Visual Experience ◽  
Brain Regions ◽  
State Condition ◽  
Resting State Functional Connectivity ◽  
Congenital Blindness ◽  
Eyes Closed ◽  
Congenitally Blind ◽  
Eyes Open

AbstractLower resting-state functional connectivity (RSFC) between ‘visual’ and non-‘visual’ neural circuits has been reported as a hallmark of congenital blindness. In sighted individuals, RSFC between visual and non-visual brain regions has been shown to increase during rest with eyes closed relative to rest with eyes open. To determine the role of visual experience on the modulation of RSFC by resting state condition—as well as to evaluate the effect of resting state condition on group differences in RSFC—, we compared RSFC between visual and somatosensory/auditory regions in congenitally blind individuals (n = 9) and sighted participants (n = 9) during eyes open and eyes closed conditions. In the sighted group, we replicated the increase of RSFC between visual and non-visual areas during rest with eyes closed relative to rest with eyes open. This was not the case in the congenitally blind group, resulting in a lower RSFC between ‘visual’ and non-‘visual’ circuits relative to sighted controls only in the eyes closed condition. These results indicate that visual experience is necessary for the modulation of RSFC by resting state condition and highlight the importance of considering whether sighted controls should be tested with eyes open or closed in studies of functional brain reorganization as a consequence of blindness.

scholarly journals Prenatal stress dysregulates resting-state functional connectivity and sensory motifs

2021 ◽  
pp. 100345
Author(s):  
Zahra Rezaei ◽  
Zahra Jafari ◽  
Navvab Afrashteh ◽  
Reza Torabi ◽  
Surjeet Singh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Prenatal Stress ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Age-related differences in resting state functional connectivity in pediatric migraine

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Tiffany Bell ◽  
Akashroop Khaira ◽  
Mehak Stokoe ◽  
Megan Webb ◽  
Melanie Noel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Power Spectra ◽  
Interaction Effects ◽  
Resting State Functional Connectivity ◽  
Default Mode ◽  
Pediatric Migraine ◽  
Age Related ◽  
Status Interaction ◽  
Underlying Mechanisms

Abstract Background Migraine affects roughly 10% of youth aged 5–15 years, however the underlying mechanisms of migraine in youth are poorly understood. Multiple structural and functional alterations have been shown in the brains of adult migraine sufferers. This study aims to investigate the effects of migraine on resting-state functional connectivity during the period of transition from childhood to adolescence, a critical period of brain development and the time when rates of pediatric chronic pain spikes. Methods Using independent component analysis, we compared resting state network spatial maps and power spectra between youth with migraine aged 7–15 and age-matched controls. Statistical comparisons were conducted using a MANCOVA analysis. Results We show (1) group by age interaction effects on connectivity in the visual and salience networks, group by sex interaction effects on connectivity in the default mode network and group by pubertal status interaction effects on connectivity in visual and frontal parietal networks, and (2) relationships between connectivity in the visual networks and the migraine cycle, and age by cycle interaction effects on connectivity in the visual, default mode and sensorimotor networks. Conclusions We demonstrate that brain alterations begin early in youth with migraine and are modulated by development. This highlights the need for further study into the neural mechanisms of migraine in youth specifically, to aid in the development of more effective treatments.

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