scholarly journals Ortho-coumaric acid derivatives with therapeutic potential in a three-dimensional culture of the immortalised U-138 MG glioblastoma multiforme cell line

2021 ◽  
Author(s):  
Yanet Karina Gutiérrez Mercado ◽  
Juan Carlos Mateos Díaz ◽  
Doddy Denise Ojeda Hernández ◽  
Francisco Javier López Gonzalez ◽  
Edwin Estefan Reza Zaldivar ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Cell Line ◽  
Therapeutic Potential ◽  
Three Dimensional ◽  
Coumaric Acid ◽  
Three Dimensional Culture

45 Three-dimensional culture systems for the reexpression of differentiation markers in a human chondrocyte cell line

1996 ◽  
Vol 12 (4-6) ◽  
pp. 389-389
Author(s):  
P. Penfornis ◽  
B. Benoit ◽  
S. Thenet-Gauci ◽  
O. Houcine ◽  
F. Marano ◽  
...  
Keyword(s):  
Cell Line ◽  
Three Dimensional ◽  
Differentiation Markers ◽  
Culture Systems ◽  
Human Chondrocyte ◽  
Three Dimensional Culture

scholarly journals Three-dimensional culture of a genetically modified hepatoma cell line using macroporous gelatin beads

2017 ◽  
Vol 69 (6) ◽  
pp. 925-931 ◽  
Author(s):  
Jane Marie Tonello ◽  
Saori Kawashima ◽  
Kazuki Sato ◽  
Yoshinori Kawabe ◽  
Akira Ito ◽  
...  
Keyword(s):  
Cell Line ◽  
Genetically Modified ◽  
Hepatoma Cell ◽  
Three Dimensional ◽  
Hepatoma Cell Line ◽  
Three Dimensional Culture

scholarly journals Comparative secretome analysis of cholangiocarcinoma cell line in three-dimensional culture

2014 ◽  
Vol 45 (5) ◽  
pp. 2108-2116 ◽  
Author(s):  
PHANTHAKARN TIT-OON ◽  
DARANEE CHOKCHAICHAMNANKIT ◽  
AMNART KHONGMANEE ◽  
PHANEE SAWANGAREETRAKUL ◽  
JISNUSON SVASTI ◽  
...  
Keyword(s):  
Cell Line ◽  
Three Dimensional ◽  
Secretome Analysis ◽  
Cholangiocarcinoma Cell ◽  
Three Dimensional Culture

In vitro Three Dimensional Scaffold-free Construct of Human Adipose-derived Stem Cells in Coculture with Endothelial Cells and Fibroblasts

2017 ◽  
Vol 68 (6) ◽  
pp. 1341-1344
Author(s):  
Grigore Berea ◽  
Gheorghe Gh. Balan ◽  
Vasile Sandru ◽  
Paul Dan Sirbu
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Endothelial Cells ◽  
Single Cell ◽  
Cell Line ◽  
Bone Repair ◽  
Umbilical Vein ◽  
Human Fibroblasts ◽  
Three Dimensional ◽  
Adipose Derived Stem Cells

Complex interactions between stem cells, vascular cells and fibroblasts represent the substrate of building microenvironment-embedded 3D structures that can be grafted or added to bone substitute scaffolds in tissue engineering or clinical bone repair. Human Adipose-derived Stem Cells (hASCs), human umbilical vein endothelial cells (HUVECs) and normal dermal human fibroblasts (NDHF) can be mixed together in three dimensional scaffold free constructs and their behaviour will emphasize their potential use as seeding points in bone tissue engineering. Various combinations of the aforementioned cell lines were compared to single cell line culture in terms of size, viability and cell proliferation. At 5 weeks, viability dropped for single cell line spheroids while addition of NDHF to hASC maintained the viability at the same level at 5 weeks Fibroblasts addition to the 3D construct of stem cells and endothelial cells improves viability and reduces proliferation as a marker of cell differentiation toward osteogenic line.

Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

2020 ◽  
Vol 27 ◽  
Author(s):  
Ji-Yeon Lee ◽  
Myoung Hee Kim
Keyword(s):  
Breast Cancer ◽  
Hox Genes ◽  
Therapeutic Potential ◽  
Expression Patterns ◽  
Genome Structure ◽  
Control Cell ◽  
Three Dimensional ◽  
Cellular Processes ◽  
Hox Protein

: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.

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