Pharmacological evaluation of the anxiolytic-like effects of EMD 386088, a partial 5-HT6 receptor agonist, in the rat elevated plus-maze and Vogel conflict tests

2014 ◽  
Vol 85 ◽  
pp. 253-262 ◽  
Author(s):  
Magdalena Jastrzębska-Więsek ◽  
Agata Siwek ◽  
Anna Partyka ◽  
Monika Kubacka ◽  
Szczepan Mogilski ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Pharmacological Evaluation ◽  
Plus Maze

Interaction of GABA (A) system in the nucleus accumbens ahell with ACPA on anxiety-like behaviors in Wistar male rat

2013 ◽  
Vol 1 (1) ◽  
pp. 44
Author(s):  
Mohammad Reza Zarrindast ◽  
Hatam Ahmadi ◽  
Mohammad Nasehi
Keyword(s):  
Locomotor Activity ◽  
Nucleus Accumbens ◽  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Male Rat ◽  
Gaba A ◽  
Test Parameters ◽  
Plus Maze ◽  
Selective Agonists

It has been recently reported that cannabinoid and GABA systems in the nucleus accumbens (NAc) are involved in anxiety-related behaviors. Thus the purpose of the present study is to investigate the involvement of ACPA interaction with GABA-ergic of the NAc shell in anxiolytic-like behaviors in Wistar male rat. The elevated plus maze apparatus has been used to test parameters of anxiety-like behaviors. The data demonstrated that bilateral injection of GABA (A) receptor agonist (Muscimol 0.4 μg/μl) increased % OAT. Furthermore, injection of GABA (A) receptor antagonist (Bicuculline 0.9μg/μl) increased locomotor activity. The data indicated anxiolytic-like behaviors caused by the Muscimol injection into the NAc shell. Moreover, bilateral injection of ACPA (CB1 -selective agonists; 0.025μg/μl) into the NAc shell induced anxiogenic-like behaviors. The final results showed that intra-NAc shell injection of subthreshold dose of Muscimol (0.2 μg/μl) attenuated anxiogenic-like behaviors by higher dose (0.025 μg/μl) of ACPA in the NAc shell. In addition, intra-NAc shell injection of subthreshold dose of Bicuculline (0.6 μg/μl) did not alter anxiogenic response by ACPA administration in the NAc shell. The results suggested that the activation of the NAc shell GABA (A) receptor attenuated the activity of cannabinoid system in the NAc shell.

scholarly journals Activation of GABAA receptors in the medial prefrontal cortex produces an anxiolytic-like response

2013 ◽  
Vol 25 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Jalal Solati ◽  
Ramin Hajikhani ◽  
Yulia Golub
Keyword(s):  
Prefrontal Cortex ◽  
Receptor Antagonist ◽  
Medial Prefrontal Cortex ◽  
Gabaa Receptors ◽  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

ObjectivesThere has been increasing evidence that the γ-aminobutyric acid (GABA)ergic system is involved in the neurobiology of anxiety. The present study aimed to investigate the role of GABAergic systems in the modulation of anxiety in the medial prefrontal cortex (mPFC) of rats using the elevated plus maze test.MethodsRats were anaesthetised with a mixture of ketamine and xylazine, and then special cannulae were inserted stereotaxically into the mPFC. After 5–7 days of recovery, the effects of intra-mPFC administration of GABAergic agents were studied.ResultsBilateral injection of the GABAA receptor agonist muscimol (0.25, 0.5 and 1 μg/rat) produces an anxiolytic-like effect, shown by significant increases in the percentage of open-arm time (%OAT) and percentage of open-arm entries (%OAE). Intra-mPFC administration of the GABAA receptor antagonist bicuculline (0.25, 0.5 and 1 μg/rat) produces significant anxiogenic-like behaviour. However, intra-mPFC injection of the GABAB receptor agonist baclofen (0.05, 0.1 and 0.2 μg/rat) and the GABAB receptor antagonist CGP35348 (5, 10 and 15 μg/rat) did not alter %OAT and %OAE significantly.ConclusionThe results of the present study demonstrate that the GABAergic system of the mPFC modulates anxiety-related behaviours of rats through GABAA receptors.

The 5-HT1A receptor agonist MKC-242 increases the exploratory activity of mice in the elevated plus-maze

2003 ◽  
Vol 458 (1-2) ◽  
pp. 141-144 ◽  
Author(s):  
Masaki Sakaue ◽  
Yukio Ago ◽  
Chikako Sowa ◽  
Yutaka Koyama ◽  
Akemichi Baba ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Exploratory Activity ◽  
Plus Maze

scholarly journals PHARMACOLOGICAL EVALUATION OF ANTIANXIETY ACTIVITY OF DESMOSTACHYA BIPINNATA LEAVES IN ANIMAL MODELS

2017 ◽  
pp. 152-154
Author(s):  
Veena Rani I. ◽  
Kiranmai G. ◽  
Ravi Pratap Pulla
Keyword(s):  
Animal Models ◽  
Psychiatric Disorder ◽  
Elevated Plus Maze ◽  
Anxiety And Depression ◽  
Significant Activity ◽  
Alcoholic Extract ◽  
Aqueous Extracts ◽  
Pharmacological Evaluation ◽  
Plus Maze ◽  
The Family

Objective: Anxiety is a widespread psychiatric disorder affecting around 5% of the population. Furthermore, it is difficult to predict patient’s response to any given treatment. In the traditional systems of medicine, many plants have been used to treat anxiety and depression for thousands of years. Desmostachyabipinnata belongs to the family Poaceae, have pharmacological actions like dysentery and menorrhagia, and as a diuretic. The present study was designed to evaluate the antianxiety activity of the alcoholic and aqueous extracts of Desmostachyabipinnata leaves in rodents.Methods: Antianxiety activity was screened by different methods like elevated plus maze model and actophotometer.Results: The results infer that reduced aversion fear elicits anti-anxiety activity.Conclusion: It was concluded that alcoholic and aqueous extracts of Desmostachyabipinnata leaves are having anti-anxiety activity among which alcoholic extract of Desmostachyabipinnata leaves showing more significant activity over the aqueous extract. 

Modulation of anxiety behavior in the elevated plus maze using peptidic oxytocin and vasopressin receptor ligands in the rat

2011 ◽  
Vol 26 (4) ◽  
pp. 532-542 ◽  
Author(s):  
Plato Mak ◽  
Christina Broussard ◽  
Kristina Vacy ◽  
Jillian H Broadbear
Keyword(s):  
Receptor Agonist ◽  
Elevated Plus Maze ◽  
Receptor Activation ◽  
Systemic Administration ◽  
Intravenous Route ◽  
Vasopressin Receptor ◽  
Receptor Blockade ◽  
Sprague Dawley ◽  
Receptor Modulation ◽  
Plus Maze

Oxytocin (OT) and arginine vasopressin (AVP), in their capacities as neuromodulators, are believed to play an important role in mood control, including regulation of the anxiety response. In the present study, the contributions of oxytocin and vasopressin receptor modulation to anxiety-like behaviors were examined in male Sprague-Dawley rats. The behavioral effects of the OT receptor agonist, carbetocin (intracerebroventricular, intravenous and intraperitoneal routes), the AVP receptor agonist desmopressin (intravenous route), and the OT/AVP1A receptor antagonist atosiban (intravenous route) were evaluated in the elevated plus maze. The benzodiazepine diazepam was included as a positive control. Central but not systemic administration of carbetocin produced pronounced anxiolytic-like behavioral changes comparable to those measured following systemic diazepam treatment. The anxiolytic efficacy of carbetocin was maintained following 10 days of once-daily treatment, contrasting with the effects of diazepam which were no longer distinguishable from saline treatment. Systemic administration of desmopressin produced anxiogenic-like effects whereas systemic atosiban produced anxiolytic-like effects. Co-administration of desmopressin with atosiban resulted in saline-like behavioral responses, implicating an AVP1A receptor mechanism in the anxiolytic and anxiogenic effects of these neuropeptides following systemic administration. A peripherally-mediated antidiuretic effect of desmopressin on water consumption was also demonstrated. These results highlight the potential therapeutic utility of AVP1A receptor blockade in the modulation of anxiety-related behaviors; AVP1A receptor blockade appears to be a more promising pharmacological target than does OT receptor activation following systemic drug administration.

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