Local low dose curcumin treatment improves functional recovery and remyelination in a rat model of sciatic nerve crush through inhibition of oxidative stress

2018 ◽  
Vol 139 ◽  
pp. 98-116 ◽  
Author(s):  
Martial Caillaud ◽  
Benjamin Chantemargue ◽  
Laurence Richard ◽  
Laetitia Vignaud ◽  
Frédéric Favreau ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Functional Recovery ◽  
Rat Model ◽  
Low Dose ◽  
Sciatic Nerve Crush ◽  
Curcumin Treatment ◽  
Nerve Crush

scholarly journals Dexamethasone Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Xinhong Feng ◽  
Wei Yuan
Keyword(s):  
Sciatic Nerve ◽  
Nerve Injury ◽  
Muscle Mass ◽  
Functional Recovery ◽  
Rat Model ◽  
Gastrocnemius Muscle ◽  
Sciatic Nerve Crush ◽  
Mass Ratio ◽  
Nerve Crush ◽  
Nerve Crush Injury

Dexamethasone is currently used for the treatment of peripheral nerve injury, but its mechanisms of action are not completely understood. Inflammation/immune response at the site of nerve lesion is known to be an essential trigger of the pathological changes that have a critical impact on nerve repair and regeneration. In this study, we observed the effects of various doses of dexamethasone on the functional recovery after sciatic nerve crush injury in a rat model. Motor functional recovery was monitored by walking track analysis and gastrocnemius muscle mass ratio. The myelinated axon number was counted by morphometric analysis. Rats administered dexamethasone by local intramuscular injection had a higher nerve function index value, increased gastrocnemius muscle mass ratio, reduced Wallerian degeneration severity, and enhanced regenerated myelinated nerve fibers. Immunohistochemical analysis was performed for CD3 expression, which is a marker for T-cell activation, and infiltration in the sciatic nerve. Dexamethasone-injected rats had fewer CD3-positive cells compared to controls. Furthermore, we found increased expression of GAP-43, which is a factor associated with development and plasticity of the nervous system, in rat nerves receiving dexamethasone. These results provide strong evidence that dexamethasone enhances sciatic nerve regeneration and function recovery in a rat model of sciatic nerve injury through immunosuppressive and potential neurotrophic effects.

Thyroxine speeds up functional recovery in a rat model of sciatic nerve crush

2021 ◽  
Author(s):  
Fariba Mahmoudi ◽  
Mozhdeh Azimpour ◽  
Arash Abdolmaleki ◽  
Abolfazl Bayrami
Keyword(s):  
Sciatic Nerve ◽  
Functional Recovery ◽  
Rat Model ◽  
Sciatic Nerve Crush ◽  
Nerve Crush

Functional Recovery and Vitamin E Level Following Sciatic Nerve Crush Injury in Normal and Diabetic Rats

1998 ◽  
Vol 96 (3-4) ◽  
pp. 245-254 ◽  
Author(s):  
Khalaf Al Moutaery ◽  
Mohammed Arshaduddin ◽  
Mohammad Tariq ◽  
Saleh Al Deeb
Keyword(s):  
Vitamin E ◽  
Sciatic Nerve ◽  
Functional Recovery ◽  
Diabetic Rats ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

2018 ◽  
Vol 28 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diego Noé Rodríguez Sánchez ◽  
Luiz Antonio de Lima Resende ◽  
Giovana Boff Araujo Pinto ◽  
Ana Lívia de Carvalho Bovolato ◽  
Fábio Sossai Possebon ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Muscle Weight ◽  
Nerve Crush ◽  
Nerve Crush Injury

Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. The present study investigated the effect of canine adipose tissue MSC (Ad-MSC) transplantation in an experimental sciatic nerve crush injury. Wistar rats were divided into three groups: sham ( n = 8); Crush+PBS ( n = 8); Crush+MSC ( n = 8). Measurements of sciatic nerve functional index (SFI), muscle mass, and electromyography (EMG) were performed. Canine Ad-MSC showed mesodermal characteristics (CD34-, CD45-, CD44+, CD90+ and CD105+) and multipotentiality due to chondrogenic, adipogenic, and osteogenic differentiation. SFI during weeks 3 and 4 was significantly higher in the Crush+MSC group ( p < 0.001). During week 4, the EMG latency in the Crush+MSC groups had better near normality ( p < 0.05). The EMG amplitude showed results close to normality during week 4 in the Crush+MSC group ( p < 0.04). There were no statistical differences in muscle weight between the groups ( p > 0.05), but there was a tendency toward weight gain in the Crush+MSC groups. Better motor functional recovery after crush and perineural canine Ad-MSC transplantation was observed during week 2. This was maintained till week 4. In conclusion, the canine Ad-MSC transplantation showed early pro-regenerative effects between 2–4 weeks in the rat model of sciatic nerve crush injury.

scholarly journals Strychnos nux-vomica L. seed preparation promotes functional recovery and attenuates oxidative stress in a mouse model of sciatic nerve crush injury

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Aroona Razzaq ◽  
Ghulam Hussain ◽  
Azhar Rasul ◽  
Jiaqi Xu ◽  
Qiqi Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sciatic Nerve ◽  
Mouse Model ◽  
Muscle Mass ◽  
Functional Recovery ◽  
Sensory Function ◽  
Sciatic Nerve Crush ◽  
Nerve Lesion ◽  
Active Constituent ◽  
Platelet Counts

Abstract Background Peripheral nerve injury is a debilitating condition that may lead to partial or complete motor, sensory and autonomic function loss and lacks effective therapy until date. Therefore, it is quite imperative to explore impending remedies for rapid and accurate functional retrieval following such conditions. Natural product-based intervention can prove effective to facilitate the process of functions regain. Methods Here, we investigated the effect of processed Strychnos nux-vomica seeds at a dose of 250 mg/kg body weight in a mouse model of induced Sciatic nerve lesion in promoting the recovery of the functions. A compression injury was induced in the Sciatic nerve of the right leg in the mice. Sensory function recovery was evaluated by hot-plate and formalin tests, whereas the motor function retrieval was assessed by measuring muscle grip strength, sciatic functional index, and muscle mass restoration. Oxidative stress and blood cell count were measured by biochemistry and haematological analyses. Results This study indicates that Strychnos nux-vomica seeds enhance the rate of recovery of both sensory and motor functions. It helps restore the muscle mass, attenuates total oxidant status and enhances the total anti-oxidant capacity of the biological system. Moreover, the treated animals manifested an enhanced glucose tolerance aptitude and augmented granulocyte and platelet counts. Improved oxidant control, enhanced glucose sensitivity and amended granulocyte and platelet counts are likely to contribute to the advantageous effects of Strychnos nux-vomica, and warrant further in-depth studies for deciphering possible mechanisms and identification of active constituent(s) responsible for these effects. Conclusion Strychnos nux-vomica seed offers functional recovery promoting effects following a mechanical injury to the Sciatic nerve and the possible reasons behind this effect can be reduced oxidative stress and improved glycaemic control. Further and detailed investigations can unravel this mystery.

scholarly journals Expression of VEGF and neural repair after alprostadil treatment in a rat model of sciatic nerve crush injury

2009 ◽  
Vol 57 (4) ◽  
pp. 387 ◽  
Author(s):  
Xinsheng Ding ◽  
Jinrong Tang ◽  
Ye Hua ◽  
Jianhua Su ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Rat Model ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Neural Repair ◽  
Nerve Crush Injury
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