The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats

Neuroscience ◽  
2012 ◽  
Vol 222 ◽  
pp. 100-109 ◽  
Author(s):  
M.S. Costa ◽  
A.P. Ardais ◽  
G.T. Fioreze ◽  
S. Mioranzza ◽  
P.H.S. Botton ◽  
...  
Keyword(s):  
Young Adult ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Moderate Exercise ◽  
Aged Rats ◽  
Middle Aged ◽  
Neurotrophic Factor Signaling ◽  
The Impact

scholarly journals Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress

2019 ◽  
Vol 148 ◽  
pp. 40-49 ◽  
Author(s):  
Anna M. Rosenhauer ◽  
Linda Q. Beach ◽  
Elizabeth C. Jeffress ◽  
Brittany M. Thompson ◽  
Katharine E. McCann ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Social Stress ◽  
Brain Derived Neurotrophic Factor ◽  
Neurotrophic Factor Signaling ◽  
The Impact

scholarly journals Restoration of Long-Term Potentiation in Middle-Aged Hippocampus After Induction of Brain-Derived Neurotrophic Factor

2006 ◽  
Vol 96 (2) ◽  
pp. 677-685 ◽  
Author(s):  
Christopher S. Rex ◽  
Julie C. Lauterborn ◽  
Ching-Yi Lin ◽  
Eniko A. Kramár ◽  
Gary A. Rogers ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Brain Derived Neurotrophic Factor ◽  
Aged Rats ◽  
Middle Aged ◽  
Age Related ◽  
Term Potentiation

Restoration of neuronal viability and synaptic plasticity through increased trophic support is widely regarded as a potential therapy for the cognitive declines that characterize aging. Previous studies have shown that in the hippocampal CA1 basal dendritic field deficits in the stabilization of long-term potentiation (LTP) are evident by middle age. The present study tested whether increasing endogenous brain-derived neurotrophic factor (BDNF) could reverse this age-related change. We report here that in middle-aged (8- to 10-mo-old) rats, in vivo treatments with a positive AMPA-type glutamate receptor modulator both increase BDNF protein levels in the cortical telencephalon and restore stabilization of basal dendritic LTP as assessed in acute hippocampal slices 18 h after the last drug treatment. These effects were not attributed to enhanced synaptic transmission or to facilitation of burst responses used to induce LTP. Increasing extracellular levels of BDNF by exogenous application to slices of middle-aged rats was also sufficient to rescue the stabilization of basal dendritic LTP. Finally, otherwise stable LTP in ampakine-treated middle-aged rats can be eliminated by infusion of the extracellular BDNF scavenger TrkB-Fc. Together these results indicate that increases in endogenous BDNF signaling can offset deficits in the postinduction processes that stabilize LTP.

scholarly journals Serum brain-derived neurotrophic factor: Determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people

2011 ◽  
Vol 13 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Boudewijn A.A. Bus ◽  
Indira Tendolkar ◽  
Barbara Franke ◽  
Jacqueline de Graaf ◽  
Martin Den Heijer ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Elderly People ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Middle Aged ◽  
Community Population

The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults: A Meta-Analysis

2019 ◽  
Vol 49 (10) ◽  
pp. 1529-1546 ◽  
Author(s):  
Nastasia Marinus ◽  
Dominique Hansen ◽  
Peter Feys ◽  
Raf Meesen ◽  
Annick Timmermans ◽  
...  
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Neurotrophic Factor ◽  
Peripheral Blood ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Brain ◽  
Different Types ◽  
The Impact
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