Acute and Chronic Pain Processing in the Thalamocortical System of Humans and Animal Models

Neuroscience ◽  
2018 ◽  
Vol 387 ◽  
pp. 58-71 ◽  
Author(s):  
Alexander Groh ◽  
Patrik Krieger ◽  
Rebecca A. Mease ◽  
Luke Henderson
Keyword(s):  
Chronic Pain ◽  
Animal Models ◽  
Pain Processing ◽  
Thalamocortical System

Pain processing in the thalamocortical system

e-Neuroforum ◽  
2017 ◽  
Vol 23 (3) ◽  
Author(s):  
Alexander Groh ◽  
Rebecca Mease ◽  
Patrik Krieger
Keyword(s):  
Nervous System ◽  
Animal Models ◽  
Signaling Pathways ◽  
Acute Pain ◽  
Negative Emotion ◽  
Pain Processing ◽  
Pathological Pain ◽  
Thalamocortical System ◽  
Noxious Stimuli ◽  
Lines Of Evidence

AbstractThe transduction of painful stimuli into the experience of pain involves several peripheral and central signaling pathways of the nervous system. The organization of these pathways parallels the main functions of pain: the assessment of noxious stimuli (where, what, how strong), and the negative emotion of unpleasantness. Multiple lines of evidence suggest that the thalamocortical (TC) system, which interprets ascending pain signals, has two main pathways which support these functions. We discuss the structural and functional findings that support the view that the lateral TC pathway is involved in discriminative assessment of pain, while the medial TC pathway gives rise to aversive emotions associated with pain. Our review focuses on acute pain, but we also discuss putative TC maladaptations in humans and animal models of pain that are thought to underlie pathological pain sensations.

scholarly journals Preclinical Science Regarding Cannabinoids as Analgesics: An Overview

2005 ◽  
Vol 10 (suppl a) ◽  
pp. 7A-14A ◽  
Author(s):  
ME Lynch
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Animal Models ◽  
Present Article ◽  
Cannabinoid Receptors ◽  
Pain Processing ◽  
Partial Synthesis ◽  
Significant Potential ◽  
The Brain ◽  
Cannabinoid Agonists

Modern pharmacology of cannabinoids began in 1964 with the isolation and partial synthesis of delta-9-tetrahydrocannabinol, the main psychoactive agent in herbal cannabis. Since then, potent antinociceptive and antihyperalgesic effects of cannabinoid agonists in animal models of acute and chronic pain; the presence of cannabinoid receptors in pain-processing areas of the brain, spinal cord and periphery; and evidence supporting endogenous modulation of pain systems by cannabinoids has provided support that cannabinoids exhibit significant potential as analgesics. The present article presents an overview of the preclinical science.

Quantitative Sensory Testing in Animal Models of Chronic Pain: A Pilot Study

2018 ◽  
Author(s):  
B. Monteiro ◽  
M. Moreau ◽  
C. Otis ◽  
L. De Lorimier ◽  
J. Pelletier ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pilot Study ◽  
Animal Models ◽  
Quantitative Sensory Testing ◽  
Sensory Testing

Animal models of chronic pain

2004 ◽  
Vol 5 (3) ◽  
pp. S1
Author(s):  
G. Iannetti ◽  
L. Zambreanu ◽  
G. Cruccu ◽  
I. Tracey
Keyword(s):  
Chronic Pain ◽  
Animal Models

scholarly journals Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Fausto Salaffi ◽  
Giovanni Giacobazzi ◽  
Marco Di Carlo
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Inflammatory Arthritis ◽  
Inflammatory Process ◽  
Pain Processing ◽  
Central Pain ◽  
The Central Nervous System ◽  
Central Pain Processing ◽  
Processing Mechanisms ◽  
Stat Pathway

Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization). In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system. This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.

Sympathetic component of neuropathic pain: Animal models and clinical diagnosis

1997 ◽  
Vol 20 (3) ◽  
pp. 468-469
Author(s):  
Laszlo A. Urban
Keyword(s):  
Experimental Data ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Animal Models ◽  
Clinical Diagnosis ◽  
Inflammatory Pain ◽  
Ongoing Debate ◽  
Pain Syndromes ◽  
Sympathetic Nervous

Although clinical studies and animal models seem to establish an important role for the sympathetic nervous system in many forms of neuropathic and inflammatory pain, there is an ongoing debate on the classification of pain syndromes with sympathetic components. The confusion originates from several sources: failure to acknowledge that the pathomechanism of chronic pain can change during the progress of the disease, which is now strongly underlined by experimental data from suitable animal models. Neuropathic pain is a vaguely defined collection of pain syndromes which includes painful conditions with diverse and largely unknown patho-mechanisms. Clinical diagnosis is difficult and well designed, placebo controlled sympathectomy is rarely performed. [blumberg et al.]

Animal Models of Chronic Pain

2004 ◽  
Vol 5 (3) ◽  
pp. S15 ◽  
Author(s):  
E. Sloane ◽  
S. Langer ◽  
E. Milligan ◽  
J. Wieseler-Frank ◽  
J. Mahoney ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Animal Models
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