Emphasizing Histone-Related Chromatin Remodeling in the Central Nervous System of Animal Models of Chronic Pain

2019 ◽  
pp. 69-83
Author(s):  
Hiroki Imbe
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Animal Models ◽  
Chromatin Remodeling ◽  
The Central Nervous System

scholarly journals West Nile Virus Infection in the Central Nervous System

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 105 ◽  
Author(s):  
Evandro R. Winkelmann ◽  
Huanle Luo ◽  
Tian Wang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
West Nile Virus ◽  
Animal Models ◽  
West Nile Virus Infection ◽  
The United States ◽  
West Nile ◽  
Neurological Sequelae ◽  
The Central Nervous System

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide.  Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae.  Neither antiviral drugs nor vaccines are available for humans.  Animal models have been used to investigate WNV pathogenesis and host immune response in humans.  In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

scholarly journals Animal Models of Subjective Tinnitus

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Wolfger von der Behrens
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Animal Models ◽  
Auditory Processing ◽  
Critical Element ◽  
Single Neurons ◽  
Ageing Society ◽  
Subjective Tinnitus ◽  
The Central Nervous System ◽  
Plastic Changes

Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society. Despite its huge personal and presumed economic impact there are only limited therapeutic options available. The reason for this deficiency lies in the very nature of the disease as it is deeply connected to elementary plasticity of auditory processing in the central nervous system. Understanding these mechanisms is essential for developing a therapy that reverses the plastic changes underlying the pathogenesis of tinnitus. This requires experiments that address individual neurons and small networks, something usually not feasible in human patients. However, in animals such invasive experiments on the level of single neurons with high spatial and temporal resolution are possible. Therefore, animal models are a very critical element in the combined efforts for engineering new therapies. This review provides an overview over the most important features of animal models of tinnitus: which laboratory species are suitable, how to induce tinnitus, and how to characterize the perceived tinnitus by behavioral means. In particular, these aspects of tinnitus animal models are discussed in the light of transferability to the human patients.

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