Association of bone morphogenic protein 4 gene polymorphism and left ventricle hypertrophy in diabetic chronic kidney disease patients: A pilot study

Aim of the Study: To study the features of the prevalence of left ventricular hypertrophy in chronic kidney disease, taking into account gender differences. Materials and Methods: This were an instant study. We examined 945 patients (360 female and 585 male) with chronic kidney disease (CKD) from the 1st to the 5th stage of the disease. The average age of the patients was 39.0±13.0 years. Glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. Results: In patients with female CKD, a significant decrease in hemoglobin, erythrocyte count, and eGFR was detected compared with males, while the incidence of hyperuricemia was significantly higher. Daily proteinuria was significantly higher in men compared with women. The prevalence of LVH was significantly higher in females compared with men (49.4% versus 35.7%; p<0.05). In women and men, the eccentric type prevailed in the structure of LVH. The number of patients with an eccentric type of LVH was significantly higher in the subgroup of females (p<0.05), and with concentric remodeling of the LV were significantly higher in males (p<0.05). Conclusion: The prevalence of LVH among the examined individuals with CKD was 40.9%. Among women, the most common type of LVH was the eccentric type of remodeling (79.2%), and among men, the concentric type of LVH was 39.7% of cases.

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Does angiotensin-converting enzyme-1 (ACE-1) gene polymorphism lead to chronic kidney disease among hypertensive patients?

Renal Failure ◽

10.3109/0886022x.2016.1160247 ◽

2016 ◽

Vol 38 (5) ◽

pp. 765-769 ◽

Cited By ~ 4

Author(s):

Taposh Sarkar ◽

Narinder Pal Singh ◽

Premashish Kar ◽

Syed Akhtar Husain ◽

Seema Kapoor ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Gene Polymorphism ◽

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Hypertensive Patients

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ACE ID gene polymorphism contributes to chronic kidney disease progression but not NOS3 gene among Type 2 diabetes with nephropathy patients

Endocrine and Metabolic Science ◽

10.1016/j.endmts.2021.100100 ◽

2021 ◽

pp. 100100

Author(s):

Deepashree G A ◽

Ramprasad E ◽

Jayakumar M ◽

Solomon F D Paul ◽

Gnanasambandan R

Keyword(s):

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Gene Polymorphism ◽

Disease Progression ◽

Chronic Kidney Disease Progression ◽

Nos3 Gene ◽

Kidney Disease Progression

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Evaluation of Interleukin 8 gene polymorphism for predicting inflammation in Indian chronic kidney disease and peritoneal dialysis patients

Alexandria Journal of Medicine ◽

10.1016/j.ajme.2016.06.004 ◽

2017 ◽

Vol 53 (3) ◽

pp. 215-220 ◽

Cited By ~ 1

Author(s):

Rajasree Shanmuganathan ◽

Kumaresan Ramanathan ◽

Giri Padmanabhan ◽

Bhooma Vijayaraghavan

Keyword(s):

Chronic Kidney Disease ◽

Peritoneal Dialysis ◽

Kidney Disease ◽

Gene Polymorphism ◽

Interleukin 8 ◽

Dialysis Patients

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Abstract W P250: The Impact of Acute Hypertensive Response on Mortality After Intracerebral Hemorrhage Differs Among Patients With and Without Left Ventricle Hypertrophy

Stroke ◽

10.1161/str.45.suppl_1.wp250 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

Octavio M Pontes-Neto ◽

Sergi Martinez-Ramirez ◽

Anand Viswanathan ◽

Timothy C Tan ◽

Maria C Nunes ◽

...

Keyword(s):

Blood Pressure ◽

Left Ventricle ◽

Acute Phase ◽

Blood Pressure Reduction ◽

Chronic Hypertension ◽

Pressure Reduction ◽

Left Ventricle Hypertrophy ◽

Ventricle Hypertrophy ◽

Haenszel Test ◽

Intensive Blood Pressure

Background: While acute hypertensive response (AHR) predicts worse outcome in intracerebral hemorrhage (ICH), the INTERACT-2 trial recently failed to definitively demonstrate a major benefit of intensive blood pressure reduction on these patients. A possible explanation is that the detrimental effect of AHR on outcome may differ among ICH patients with and without previous chronic hypertension. Objective: to explore whether the prognosis of patients with AHR during the acute phase of ICH differs according to the presence or absence of left ventricle hypertrophy (LVH), which is a marker of chronic hypertensive organ damage. Method: we performed a retrospective analysis of a prospective cohort of patients with primary ICH presenting to an academic hospital between January/2000 and December/2012 with age > 18 years, who had a transthoracic echocardiogram available. LVH was defined according to Penn convention. AHR was defined as systolic blood pressure > 180 mmHg on admission. Mantel-Haenszel test was initially used to assess if LVH status influenced the effect of AHR on mortality. For subsequent analyses, ICH patients were divided in 3 groups: without AHR (reference); AHR without LVH; AHR with LVH. A multivariate logistic regression model was then used to identify independent predictors of mortality at 30-days. Results: 430 patients met inclusion criteria. AHR was present in 196 (46.6%), LVH was present in 233 (54.2%); 30-day mortality was 15.6%. On Mantel-Haenszel test, we found a trend (p=0.09) suggesting that absence of LVH increased AHR effect on mortality (OR:1.64; 95% CI: 0.95-2.8; p=0.07). On multivariate analysis, patients with AHR without LVH had significantly higher mortality (OR: 2.65; 95%CI: 1.15 to 6.1; p=0.022) when compared to patients without AHR, after adjusting for baseline characteristics. There was only a trend towards increased mortality in the group of patients with AHR and LVH (OR:2.22; 95% CI: 0.99-5.0; p=0.053). Conclusions: Patients without chronic hypertension appear to be more susceptible to the detrimental effects of AHR during the acute phase of ICH. Stratification of patients with ICH may help to identify those that will have greater benefit with intensive blood pressure reduction in the acute phase of ICH.

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