scholarly journals Characterisation of brain volume and microstructure at term-equivalent age in infants born across the gestational age spectrum

2019 ◽  
Vol 21 ◽  
pp. 101630 ◽  
Author(s):  
Deanne K. Thompson ◽  
Claire E. Kelly ◽  
Jian Chen ◽  
Richard Beare ◽  
Bonnie Alexander ◽  
...  
Keyword(s):  
Gestational Age ◽  
Brain Volume ◽  
Equivalent Age

scholarly journals Habituation as Parameter for Prediction of Mental Development in Healthy Preterm Infants

2016 ◽  
Vol 31 (14) ◽  
pp. 1591-1597 ◽  
Author(s):  
Peter Weber ◽  
Antoinette Depoorter ◽  
Patrick Hetzel ◽  
Sakari Lemola
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Mismatch Negativity ◽  
Infant Development ◽  
Mental Development ◽  
Learning Capability ◽  
Equivalent Age ◽  
Developmental Index ◽  
And Performance ◽  
Mental Developmental Index

The aim of this prospective pilot study was to evaluate the predictive value of discrimination and habituation, which was measured by mismatch negativity in 17 healthy very preterm (mean gestational age 27.4 weeks; range 25.0-31.3) and 16 term (mean gestational age 40.3 weeks; range 37.9-41.7) born infants at term equivalent age. Developmental outcome was measured by Bayley Scales of Infant Development–I in 13 preterm and 13 term-born children at a mean age of 21.7 months (±2.18) and 18.5 months (±1.9), respectively. No differences in amplitude and latency of the mismatch negativity were found between both groups at term equivalent age. Within the preterm group habituation capacity was positively correlated with the Mental Developmental Index ( r = .654, P = .008) and Performance Developmental Index ( r = .482, P = .048) at 21 months. Early learning capability, as measured by habituation, may be associated with a better prognosis for early mental development in healthy preterm infants.

Early life predictors of brain development at term-equivalent age in infants born across the gestational age spectrum

NeuroImage ◽  
2019 ◽  
Vol 185 ◽  
pp. 813-824 ◽  
Author(s):  
Deanne K. Thompson ◽  
Claire E. Kelly ◽  
Jian Chen ◽  
Richard Beare ◽  
Bonnie Alexander ◽  
...  
Keyword(s):  
Brain Development ◽  
Gestational Age ◽  
Early Life ◽  
Equivalent Age

Adiposity in small for gestational age preterm infants assessed at term equivalent age

2009 ◽  
Vol 94 (5) ◽  
pp. F368-F372 ◽  
Author(s):  
M L Gianni ◽  
P Roggero ◽  
F Taroni ◽  
N Liotto ◽  
P Piemontese ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Equivalent Age

scholarly journals Effects of gestational age on brain volume and cognitive functions in generally healthy very preterm born children during school-age: A voxel-based morphometry study

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183519 ◽  
Author(s):  
Sakari Lemola ◽  
Nadine Oser ◽  
Natalie Urfer-Maurer ◽  
Serge Brand ◽  
Edith Holsboer-Trachsler ◽  
...  
Keyword(s):  
Gestational Age ◽  
Cognitive Functions ◽  
Brain Volume ◽  
School Age ◽  
Voxel Based Morphometry ◽  
Very Preterm ◽  
Preterm Born

scholarly journals Multiparametric Analysis of Cerebral Development in Preterm Infants Using Magnetic Resonance Imaging

2021 ◽  
Vol 15 ◽  
Author(s):  
Marine Dubois ◽  
Antoine Legouhy ◽  
Isabelle Corouge ◽  
Olivier Commowick ◽  
Baptiste Morel ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Preterm Infants ◽  
Gestational Age ◽  
Brain Maturation ◽  
Resonance Imaging ◽  
Equivalent Age ◽  
Very Preterm ◽  
Extremely Preterm ◽  
The Impact

ObjectivesThe severity of neurocognitive impairment increases with prematurity. However, its mechanisms remain poorly understood. Our aim was firstly to identify multiparametric magnetic resonance imaging (MRI) markers that differ according to the degree of prematurity, and secondly to evaluate the impact of clinical complications on these markers.Materials and MethodsWe prospectively enrolled preterm infants who were divided into two groups according to their degree of prematurity: extremely preterm (<28 weeks’ gestational age) and very preterm (28–32 weeks’ gestational age). They underwent a multiparametric brain MRI scan at term-equivalent age including morphological, diffusion tensor and arterial spin labeling (ASL) perfusion sequences. We quantified overall and regional volumes, diffusion parameters, and cerebral blood flow (CBF). We then compared the parameters for the two groups. We also assessed the effects of clinical data and potential MRI morphological abnormalities on those parameters.ResultsThirty-four preterm infants were included. Extremely preterm infants (n = 13) had significantly higher frontal relative volumes (p = 0.04), frontal GM relative volumes (p = 0.03), and regional CBF than very preterm infants, but they had lower brainstem and insular relative volumes (respectively p = 0.008 and 0.04). Preterm infants with WM lesions on MRI had significantly lower overall GM CBF (13.3 ± 2 ml/100 g/min versus 17.7 ± 2.5, < ml/100 g/min p = 0.03).ConclusionMagnetic resonance imaging brain scans performed at term-equivalent age in preterm infants provide quantitative imaging parameters that differ with respect to the degree of prematurity, related to brain maturation.

scholarly journals Novel Diffuse White Matter Abnormality Biomarker at Term-Equivalent Age Enhances Prediction of Long-term Motor Development in Children Born Very Preterm

2020 ◽  
Author(s):  
Nehal A Parikh ◽  
Karen Harpster ◽  
Lili He ◽  
Venkata Sita Priyanka Illapani ◽  
Fatima Chughtai Khalid ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Motor Development ◽  
Prognostic Biomarker ◽  
White Matter Abnormality ◽  
Very Preterm Infants ◽  
Equivalent Age ◽  
Very Preterm ◽  
Diffuse White Matter

Our objective was to evaluate the independent prognostic value of a novel MRI biomarker − objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity) − for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores (β= −12.59 [95% CI: −18.70, −6.48] R2=0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.

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