Expression of myofibrillar myopathy gene products in the nervous system

2017 ◽  
Vol 27 ◽  
pp. S121
Author(s):  
Y. Blech-Hermoni ◽  
S. Coscia ◽  
L. Jensen ◽  
M. Kates ◽  
K. Subedi ◽  
...  
Keyword(s):  
Nervous System ◽  
Gene Products ◽  
Myofibrillar Myopathy

Neurofilament proteins and human nervous system tumors.

1987 ◽  
Vol 35 (9) ◽  
pp. 999-1003 ◽  
Author(s):  
J Q Trojanowski
Keyword(s):  
Nervous System ◽  
Molecular Probes ◽  
Cytoskeletal Proteins ◽  
Diagnostic Assessment ◽  
Critical Examination ◽  
Specific Gene ◽  
Specific Class ◽  
Gene Products ◽  
Carotid Body Tumors ◽  
Human Nervous System

Neoplasms that arise in the peripheral (e.g., carotid body tumors, neuroblastomas, pheochromocytomas) or central (gangliocytomas, medulloblastomas) nervous system express a number of neuron-specific gene products. Presumably, these tumors are derived from precursor cells that are or have the potential to develop into neurons or neuron-like cells. This report provides a critical examination of the hypothesis that cytoskeletal proteins of normal neurons, in particular the neuron-specific class of intermediate filaments (neurofilaments), are present but are abnormal in neoplasms derived from neurons or neuron-like cells. The implications of these findings for understanding tumor promotion and progression, and for development of molecular probes for the diagnostic assessment of these neoplasms, are discussed.

scholarly journals Detection of human cytomegalovirus genome and gene products in central nervous system tumours

2005 ◽  
Vol 92 (4) ◽  
pp. 747-750 ◽  
Author(s):  
J Sabatier ◽  
E Uro-Coste ◽  
I Pommepuy ◽  
F Labrousse ◽  
S Allart ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human Cytomegalovirus ◽  
Gene Products ◽  
Central Nervous System Tumours

Genetics of Behavior in C. elegans

2017 ◽  
pp. 150-170 ◽  
Author(s):  
Denise S. Walker ◽  
Yee Lian Chew ◽  
William R. Schafer
Keyword(s):  
Nervous System ◽  
Caenorhabditis Elegans ◽  
Molecular Genetics ◽  
Sensory Information ◽  
Macro Level ◽  
Gene Products ◽  
Individual Gene ◽  
C Elegans ◽  
Behavioral States ◽  
Motor Outputs

The nematode Caenorhabditis elegans is among the most intensely studied animals in modern experimental biology. In particular, because of its amenability to classical and molecular genetics, its simple and compact nervous system, and its transparency to optogenetic recording and manipulation, C. elegans has been widely used to investigate how individual gene products act in the context of neuronal circuits to generate behavior. C. elegans is the first and at present the only animal whose neuronal connectome has been characterized at the level of individual neurons and synapses, and the wiring of this connectome shows surprising parallels with the micro- and macro-level structures of larger brains. This chapter reviews our current molecular- and circuit-level understanding of behavior in C. elegans. In particular, we discuss mechanisms underlying the processing of sensory information, the generation of specific motor outputs, and the control of behavioral states.

scholarly journals Distribution of the Sex combs reduced Gene Products in Drosophila melanogaster

Genetics ◽  
1987 ◽  
Vol 117 (1) ◽  
pp. 51-60
Author(s):  
James W Mahaffey ◽  
Thomas C Kaufman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Temporal Distribution ◽  
Spatial And Temporal Distribution ◽  
Gene Products ◽  
Genetic Studies ◽  
Sex Combs Reduced ◽  
Sex Combs ◽  
The Central Nervous System ◽  
Differential Timing

ABSTRACT The spatial and temporal distribution of RNA and protein encoded by the homeotic Sex combs reduced (Scr) gene were examined during Drosophila development. The gene products are present in the epidermis of both the labial and first thoracic segments as would be predicted from prior genetic studies. However, the pattern in the central nervous system (CNS) and mesoderm is further restricted; the major expression located in the labial neuromere of the CNS and the mesoderm of the first thoracic segment. The spatial restriction within the CNS is correlated with and may be due to a differential timing of expression in the labial and first thoracic ectoderm. The labial ectoderm accumulates the Scr RNA prior to segregation of the neuroblasts while expression in the first thoracic ectoderm occurs after neuroblast segregation. The protein is also observed in the subesophageal ganglia of both larvae and adults, as well as in the labial and first thoracic imaginal discs. Surprisingly, the protein is also present to a lesser extent in second and third thoracic leg discs.

Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues

2000 ◽  
Vol 99 (3) ◽  
pp. 223-230 ◽  
Author(s):  
D. H. Gutmann ◽  
Y. Zhang ◽  
M. J. Hasbani ◽  
M. P. Goldberg ◽  
T. L. Plank ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Gene Products

scholarly journals The Secret Garden of Neuronal circRNAs

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1815
Author(s):  
Silvia Gasparini ◽  
Valerio Licursi ◽  
Carlo Presutti ◽  
Cecilia Mannironi
Keyword(s):  
Gene Expression ◽  
Nervous System ◽  
Gene Expression Regulation ◽  
Biological Activities ◽  
Circular Rnas ◽  
Gene Products ◽  
Developmentally Regulated ◽  
Neuronal Gene ◽  
Neuronal Proteins ◽  
The Secret Garden

High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-specific, and enriched in genes for neuronal proteins and synaptic factors. These features suggested that circRNAs are key components of an important layer of neuronal gene expression regulation, with known and anticipated functions. Here, we review major recognized aspects of circRNA biogenesis, metabolism and biological activities, examining potential new functions in the context of the nervous system.

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