scholarly journals Posttraumatic stress disorder, alone or additively with early life adversity, is associated with obesity and cardiometabolic risk

2015 ◽  
Vol 25 (5) ◽  
pp. 479-488 ◽  
Author(s):  
O.M. Farr ◽  
B.-J. Ko ◽  
K.E. Joung ◽  
L. Zaichenko ◽  
N. Usher ◽  
...  
2020 ◽  
pp. 088626052093851
Author(s):  
Meghan E. Pierce ◽  
Catherine Fortier ◽  
Jennifer R. Fonda ◽  
William Milberg ◽  
Regina McGlinchey

Intimate partner violence (IPV) refers to emotional, physical, and/or sexual abuse perpetrated by a current or former partner. IPV affects both genders, though little is known about its effects on men as victims. The aims of this study were to determine if IPV is a factor contributing to posttraumatic stress disorder (PTSD) severity independently of deployment-related trauma, and to determine if there are gender differences in these associations. Participants were 46 female and 471 male post-9/11 veterans. Four sequential regressions were employed to examine the independent contribution of IPV among multiple trauma types on PTSD severity in men and women at two epochs, post-deployment (participants were anchored to deployment-related PTSD symptoms) and current (within the past month). Models were significant for both epochs in men ( ps < .001) but not in women ( ps > .230). In men, IPV independently predicted PTSD severity in both epochs (β > .093). However, in women, early life trauma (β = .284), but not IPV was a significant and independent predictor for current PTSD. Thus, there are distinct gender differences in how trauma type contributes to PTSD symptom severity. Although the statistical models were not significant in women, we observed similar patterns of results as in men and, in some cases, the β was actually higher in women than in men, suggesting a lack of power in our analyses. More research is clearly needed to follow-up these results; however, our findings indicate that IPV is a contributing factor to PTSD severity in veterans.


2019 ◽  
Vol 29 (3) ◽  
pp. 335-343 ◽  
Author(s):  
Lauren E. Salminen ◽  
Rajendra A. Morey ◽  
Brandalyn C. Riedel ◽  
Neda Jahanshad ◽  
Emily L. Dennis ◽  
...  

2012 ◽  
Vol 19 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Rodrigo Pestana Lopes ◽  
Rodrigo Grassi-Oliveira ◽  
Lettícia R. de Almeida ◽  
Lilian Milnitsky Stein ◽  
Clarice Luz ◽  
...  

2018 ◽  
Author(s):  
Lauren E. Salminen ◽  
Rajendra A. Morey ◽  
Brandalyn C. Riedel ◽  
Neda Jahanshad ◽  
Emily L. Dennis ◽  
...  

ABSTRACTBackground and PurposePosttraumatic stress disorder (PTSD) is a heterogeneous condition associated with a range of brain imaging abnormalities. Early life stress (ELS) contributes to this heterogeneity, but we do not know how a history of ELS influences traditionally defined brain signatures of PTSD. Here we used a novel machine learning method - evolving partitions to improve classification (EPIC) - to identify shared and unique structural neuroimaging markers of ELS and PTSD in 97 combat-exposed military veterans.MethodsWe used EPIC with repeated cross-validation to determine how combinations of cortical thickness, surface area, and subcortical brain volumes could contribute to classification of PTSD (n=40) versus controls (n=57), and classification of ELS within the PTSD (ELS+ n=16; ELS-n=24) and control groups (ELS+ n=16; ELS- n=41). Additional inputs included intracranial volume, age, sex, adult trauma, and depression.ResultsOn average, EPIC classified PTSD with 69% accuracy (SD=5%), and ELS with 64% accuracy in the PTSD group (SD=10%), and 62% accuracy in controls (SD=6%). EPIC selected unique sets of individual features that classified each group with 75-85% accuracy in post hoc analyses; combinations of regions marginally improved classification from the individual atlas-defined brain regions. Across analyses, surface area in the right posterior cingulate was the only variable that was repeatedly selected as an important feature for classification of PTSD and ELS.ConclusionsEPIC revealed unique patterns of features that distinguished PTSD and ELS in this sample of combat-exposed military veterans, which may represent distinct biotypes of stress-related neuropathology.


2020 ◽  
Vol 10 (3) ◽  
pp. 169 ◽  
Author(s):  
Panagiota Pervanidou ◽  
Gerasimos Makris ◽  
George Chrousos ◽  
Agorastos Agorastos

Traumatic stress exposure during critical periods of development may have essential and long-lasting effects on the physical and mental health of individuals. Two thirds of youth are exposed to potentially traumatic experiences by the age of 17, and approximately 5% of adolescents meet lifetime criteria for posttraumatic stress disorder (PTSD). The role of the stress system is the maintenance of homeostasis in the presence of real/perceived and acute/chronic stressors. Early-life stress (ELS) has an impact on neuronal brain networks involved in stress reactions, and could exert a programming effect on glucocorticoid signaling. Studies on pediatric PTSD reveal diverse neuroendocrine responses to adverse events and related long-term neuroendocrine and epigenetic alterations. Neuroendocrine, neuroimaging, and genetic studies in children with PTSD and ELS experiences are crucial in understanding risk and resilience factors, and also the natural history of PTSD.


Author(s):  
Daniel M. Doleys ◽  
Nicholas D. Doleys

The impact of an accident or injury, even if the physical consequences seem relatively minor in nature, can have a prolonged effect on an individual’s psychological well-being. Emotionally traumatic, early-life experiences, have been linked to certain chronic pain problems. Some patients are embarrassed by the effect and feel they should be mentally strong enough to overcome it. Others submit to it and become immobilized. It can significantly magnify the experience of pain. Recognition and treatment of posttraumatic stress disorder need not be overly complicated. Some cases may require referral to a specialist. Nightmares, flash backs, hypervigilance, and avoidance are common.


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