Association between E-cigarette use and oral HPV-16 infection

Abstract Objective : To determine the conformity of HPV type 16 and 18 in cervical and oral/buccal specimens from cervical cancer patients. Methods :A cross-sectional study was conducted in March - September 2016 at several hospitals in Makassar. HPV 16 and 18 genotyping in cervical and oral fluid of 77 patients with cervical cancer performed with PCR method. Results : The prevalence of HPV type 18 infection both in the cervical and the oral fluid was higher than HPV type 16 [9(47.4%) vs 5(26.3%)]. The aggreement of HPV type 18 infection (r=0.328;p=0.000) in the cervical-oral sites was higher than HPV type 16 (r=0.194;p=0.042). Conclusion : HPV type 16 and 18 could infect both cervix and oral cavity although type-specific concordance is low. Keywords :Human papillomavirus,servix, oral cavity Abstrak Tujuan: Mengetahui tingkat kesesuaian hasil pemeriksaan HPV tipe 16 dan 18 antara spesimen serviks dan oral/buccal pada penderita kanker serviks. Metode: Penelitian cross sectional ini dilakukan pada Maret – September 2016 pada beberapa rumah sakit di Makassar. Pemeriksaan HPV 16 dan 18 pada cairan serviks dan oral dari 77 orang penderita kanker serviks menggunakan teknik PCR. Hasil: Prevalensi infeksi bersama pada serviks dan oral HPV tipe 18 lebih tinggi dibandingkan HPV tipe 16 [9(47,4%) vs 5(26,3%)]. Tingkat kesesuaian antara HPV tipe 18 (r=0,328;p=0,000) pada serviks dan oral lebih tinggi dibandingkan tipe 16 (r=0,194;p=0,042). Kesimpulan: HPV tipe 16 dan 18 dapat menginfeksi serviks dan oral meskipun tingkat kesesuaian kedua tipe ini lemah. Kata kunci : Human papillomavirus, serviks, kavum oral

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Tobacco Use and Oral HPV-16 Infection

JAMA ◽

10.1001/jama.2014.13183 ◽

2014 ◽

Vol 312 (14) ◽

pp. 1465 ◽

Cited By ~ 42

Author(s):

Carole Fakhry ◽

Maura L. Gillison ◽

Gypsyamber D’Souza

Keyword(s):

Tobacco Use ◽

Hpv 16 ◽

Oral Hpv

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More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population

BMC Infectious Diseases ◽

10.1186/1471-2334-6-95 ◽

2006 ◽

Vol 6 (1) ◽

Cited By ~ 19

Author(s):

Dianne J Marais ◽

Candice Sampson ◽

Anthea Jeftha ◽

Dherendra Dhaya ◽

Jo-Ann S Passmore ◽

...

Keyword(s):

Human Papillomavirus ◽

Healthy Population ◽

Hpv 16 ◽

Human Papillomavirus Type 16 ◽

Iga Antibodies ◽

Oral Hpv ◽

Hpv 18

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Effect of vaccination against oral HPV-16 infection in high school students in the city of Cali, Colombia

Papillomavirus Research ◽

10.1016/j.pvr.2019.03.001 ◽

2019 ◽

Vol 7 ◽

pp. 112-117

Author(s):

Andres Castillo ◽

Julio Cesar Osorio ◽

Adrián Fernández ◽

Fabián Méndez ◽

Liliana Alarcón ◽

...

Keyword(s):

High School ◽

High School Students ◽

School Students ◽

Hpv 16 ◽

Oral Hpv ◽

The City

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Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort

BMJ Open ◽

10.1136/bmjopen-2020-046928 ◽

2021 ◽

Vol 11 (6) ◽

pp. e046928

Author(s):

Lisa M Jamieson ◽

Gail Garvey ◽

Joanne Hedges ◽

Cathy Leane ◽

Isaac Hill ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Hpv Vaccination ◽

Hpv Infection ◽

Indigenous Australians ◽

Health State ◽

Hpv 16 ◽

Oral Hpv ◽

Hpv Types

PurposeOur aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians.ParticipantsParticipants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted.Findings to dateOf the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up).Future plansFurther funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken.

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HPV infection and carcinogenesis in the upper aero-digestive tract

Colombia Medica ◽

10.25100/cm.v42i2.777 ◽

2011 ◽

pp. 233-242 ◽

Cited By ~ 4

Author(s):

Andrés Castillo

Keyword(s):

Digestive Tract ◽

Epidemiological Studies ◽

Hpv Infection ◽

Oral Sex ◽

Main Risk Factor ◽

Hpv 16 ◽

Oral Cancers ◽

Etiologic Role ◽

High Risk Type ◽

Oral Hpv

Recently, molecular and epidemiological studies have shown an etiologic role for human papillomavirus (HPV) in a subset of upper aero-digestive tract (UADT) cancers in women and men. Oral HPV infections acquired through oral sex seems to be the main risk factor for HPV-associated oral cancers. The high-risk type HPV-16 was the most prevalent infection HPV-positive in most oral cancers. Therefore, the prophylactic vaccine against HPV-16 could prevent HPV associated oral cancer if the vaccine were demonstrated to be capable of preventing oral HPV-16 infection. Thus, these findings have created new potential opportunities for the primary prevention of oral cancers.

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Long-term Persistence of Oral HPV Over 7 Years of Follow-up

JNCI Cancer Spectrum ◽

10.1093/jncics/pkaa047 ◽

2020 ◽

Vol 4 (5) ◽

Cited By ~ 2

Author(s):

Gypsyamber D’Souza ◽

Gwendolyn Clemens ◽

Howard D Strickler ◽

Dorothy J Wiley ◽

Tanya Troy ◽

...

Keyword(s):

Hpv Infection ◽

People Living With Hiv ◽

Hpv 16 ◽

Cox Models ◽

Persistent Infections ◽

Oral Rinse ◽

Hpv Clearance ◽

Oral Hpv ◽

Living With Hiv

Abstract Background Human papillomavirus–related oropharyngeal cancer (HPV-OPC) incidence is increasing, but the natural history of the precursor—oral HPV—has not been well described. Methods This observational cohort study of people living with HIV and at-risk HIV uninfected people evaluated participants semiannually using 30-second oral rinse and gargle specimens over 7 years. Initially, 447 participants were followed for 4 years as part of the Persistent Oral Papillomavirus Study, and a subset of 128 who showed persistent infections at the last Persistent Oral Papillomavirus Study visit had an additional visit, as part of the Men and Women Understanding Throat HPV Study, on average 2.5 years later. Extracted DNA from oral rinse and gargle specimens was amplified using polymerase chain reaction and type specification of 13 oncogenic HPV types. Risk factors for oncogenic oral HPV clearance were evaluated using Cox models. Results The majority of oncogenic oral HPV infections cleared quickly, with a median time to clearance of 1.4 years (interquartile range = 0.5-3.9 years). After 7 years of follow-up, 97% of incident and 71% of prevalent infections had cleared. Lower HPV-16 viral load was statistically significantly associated with clearance (per 10-fold decrease in copy number: adjusted hazard ratio [aHR] = 2.51, 95% confidence interval [CI] = 1.20 to 5.26; P = .01). Adjusted analyses showed that oncogenic oral HPV clearance was lower among prevalent than incident-detected infections (aHR = 0.44, 95% CI = 0.35 to 0.55), among men than women (aHR = 0.74, 95% CI = 0.60 to 0.91), for older participants (aHR per 10 years increasing age = 0.81, 95% CI = 0.74 to 0.89), and among people living with HIV (aHR = 0.76, 95% CI = 0.60 to 0.95). One participant who had oral HPV-16 consistently detected at 10 study visits over 4.5 years was subsequently diagnosed with HPV-OPC. Conclusions This prospective study of oncogenic oral HPV infection is the longest and largest quantification of oral HPV-16 infections to date.

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