Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

SUMMARYHistorically, Parkinson's disease was viewed as a motor disorder and it is only in recent years that the spectrum of non-motor disorders associated with the condition has been fully recognised. There is a broad scope of neuropsychiatric manifestations, including depression, anxiety, apathy, psychosis and cognitive impairment. Patients are more predisposed to delirium, and Parkinson's disease treatments give rise to specific syndromes, including impulse control disorders, dopamine agonist withdrawal syndrome and dopamine dysregulation syndrome. This article gives a broad overview of the spectrum of these conditions, describes the association with severity of Parkinson's disease and the degree to which dopaminergic degeneration and/or treatment influence symptoms. We highlight useful assessment scales that inform diagnosis and current treatment strategies to ameliorate these troublesome symptoms, which frequently negatively affect quality of life.

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Levodopa-induced breathing, cognitive and behavioral changes in Parkinson’s disease

Journal of Neurology ◽

10.1007/s00415-011-6119-5 ◽

2011 ◽

Vol 258 (12) ◽

pp. 2296-2299 ◽

Cited By ~ 5

Author(s):

Nicola Tambasco ◽

Vincenzo Belcastro ◽

Antongiulio Gallina ◽

Anna Castrioto ◽

Paolo Calabresi ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Behavioral Changes

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The thrill of reckless driving in patients with Parkinson's disease: An additional behavioural phenomenon in dopamine dysregulation syndrome?

Parkinsonism & Related Disorders ◽

10.1016/j.parkreldis.2007.04.006 ◽

2008 ◽

Vol 14 (3) ◽

pp. 257-258 ◽

Cited By ~ 21

Author(s):

Maurizio Avanzi ◽

Mario Baratti ◽

Silvia Cabrini ◽

Elena Uber ◽

Gianni Brighetti ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Dopamine Dysregulation Syndrome ◽

Reckless Driving

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The proteasome inhibition mouse model of Parkinson's disease: insights into molecular and behavioral changes following intranigral lactacystin injection

Frontiers in Neuroscience ◽

10.3389/conf.fnins.2015.89.00051 ◽

2015 ◽

Vol 9 ◽

Author(s):

Bentea Eduard ◽

Van Der Perren Anke ◽

Van Liefferinge Joeri ◽

Sconce Michelle ◽

Churchill Madeline ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Mouse Model ◽

Proteasome Inhibition ◽

Behavioral Changes

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Executive dysfunctions and behavioral changes in early drug-naïve patients with Parkinson's disease

Journal of Affective Disorders ◽

10.1016/j.jad.2018.09.052 ◽

2019 ◽

Vol 243 ◽

pp. 525-530

Author(s):

Shirong Li ◽

Ruwei Ou ◽

Xiaoqin Yuan ◽

Hui Liu ◽

Yanbing Hou ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Behavioral Changes ◽

Drug Naïve ◽

Executive Dysfunctions ◽

Early Drug

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Mirroring Emotions: Patients' Versus Caregivers' Perceptions of Sexual Experience in Parkinson's Disease

10.21203/rs.3.rs-1099815/v1 ◽

2021 ◽

Author(s):

Giovanni Landi ◽

Maria Rita Lo Monaco ◽

Enrico Di Stasio ◽

Diego Ricciardi ◽

Marcella Solito ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Early Stage ◽

Sexual Experience ◽

Behavioral Changes ◽

Dyadic Relationship ◽

Complex Process ◽

Sexual Wellbeing ◽

Effect Of Pd

Abstract Background and aims: The need for intimacy and sexual expression is an essential dimension of quality of life. As patients with Parkinson's disease (PD) have to cope with essential changes in their global and sexual functioning, achieving a satisfying intimate and sexual relationship can be challenging. Sexual experience is a complex process that involves a dyadic relationship. In this study, we aimed to characterize the sexual experience of patients with Parkinson's disease and patients' vs caregivers' perceptions. Methods Twenty-seven PD patients and their caregivers were asked to complete the Arizona Sexual Experience Scale (ASEX) anonymously. They were instructed to refer to their sexual behavior over the past year and to consider behavioral changes that lasted for at least four consecutive weeks. Results Our data suggest that when considering sexual perceptions in PD, there is often agreement of judgment between patients and their partners. Overall, they have a rather good sex life, especially in the early stage of the disease, with similar behavior shown by men and women. Conclusions The effect of PD on the sexual and couple relationship challenges healthcare professionals to focus on the needs of both partners and to plan specific interventions in such a way as to prevent the deterioration of the couples' sexual wellbeing.

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