Dissociations among daytime sleepiness, nighttime sleep, and cognitive status in Parkinson's disease

According to numerous worldwide studies, patients with Parkinson’s disease (PD) often experience sleep disturbances, the most common of which are insomnia and excessive daytime sleepiness. The purpose of this study was to determine the quantitative and qualitative profile of sleep disorders in patients with the newly diagnosed PD, stages 1 and 2 according to Hoehn and Yahr. The assessment was carried out using the SCOPA-SLEEP scale. The study involved 95 people: 56 patients with a newly diagnosed PD, who had not previously received treatment (main group), and 39 individuals from the control group. Results. The profile of nocturnal sleep disturbances in PD patients was characterized by various symptoms: difficulty falling asleep (62,5%), night awakening (51,8%), long lying awake (57,1%), early awakening (50,0%), feeling lack of sleep (46,4%). In women, irrespective of the form and stage of PD, disturbances in nighttime sleep were found more often. Daytime hypersomnia among healthy volunteers was observed only in 5 participants (12,8%). The profile of daytime hypersomnia in PD patients was diverse: unexpected falling asleep during the day (n = 15, 26,8%), falling asleep in a calm environment (n = 17, 30,4%) or while reading and watching TV (n = 18, 32,1%). Difficulties in maintaining wakefulness during the day were noted by 13 patients (n = 13, 23,2%) with PD, and 4 patients (7,2%) reported difficulties due to excessive daytime sleepiness. Thus, given the prevalence and profile of dyssomnias, sleep disturbances may be an important sign of PD.

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Early Daytime Sleepiness and Nighttime Slow-wave Sleep Disorganization in Progressive Macaque Model of Parkinson’s Disease

10.21203/rs.3.rs-1216338/v1 ◽

2022 ◽

Author(s):

Aurélie Davin ◽

Stéphan Chabardès ◽

Hayat Belaid ◽

Daniel Fagret ◽

Loic Djaileb ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Early Stage ◽

Clinical Signs ◽

Human Condition ◽

Sleep Behavior ◽

Behavior Disturbances ◽

Nighttime Sleep

Abstract Parkinsonian patients often experience wake/sleep behavior disturbances, which can appear at an early stage of the disease in a way that is still not fully described. We aimed here at reproducing and characterizing these clinical signs in a progressive non-human primate model of the Parkinson’s disease to better understand the underlying physiopathology and to identify biomarkers of the disease. Three adult non-human primates (macaca fascicularis) were equipped with a polysomnographic telemetry system allowing the characterization of the wake/sleep behavior by long-term neurophysiological recordings and a modified multiple sleep latency test. Experiments were first performed in healthy animals and then during the progressive induction of a parkinsonian syndrome by chronic intramuscular injections of low doses of MPTP. We observed a significant early onset of wake/sleep behavior disturbances, before any motor symptoms, resulting in (i) a disorganization of nighttime sleep with more deep sleep and (ii) a disorganization of daytime naps with an excessive daytime sleepiness characterized by longer duration of naps, which occurred faster. These observations persisted and worsened in stable symptomatic state. In that latter state, we observed persistent excessive daytime sleepiness and more disorganized nighttime sleep architecture and continuity. Interpolating to the human condition, the present study suggests that nighttime and daytime sleep disorders may appear in early stage of the disease. They could thus be used as biomarkers of the disease for early stratification of patients who are at risk of developing Parkinson’s disease.

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Critical issues of the biopsychosocial treatment of Parkinson’s disease

Orvosi Hetilap ◽

10.1556/oh.2015.30109 ◽

2015 ◽

Vol 156 (12) ◽

pp. 472-478 ◽

Cited By ~ 1

Author(s):

Péter Kincses ◽

Norbert Kovács ◽

Kázmér Karádi ◽

János Kállai

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Psychological Health ◽

Interdisciplinary Approach ◽

Cognitive Status ◽

Psychological Burden ◽

Her Family ◽

Critical Issues

This paper is a summary report on the basic questions of the biopsychosocial approach to Parkinson’s disease. It deals with cognitive, affective and psychological health issues which significantly influence the outcome of the physical rehabilitation. In spite of the unchanged cognitive status, the psychological burden of the changes in the quality of life, the obstruction, the change in the affective tone, and the shrinking ability to fulfil social roles decrease the patient’s quality of life. An interdisciplinary approach is best suited for mitigating these effects. Not only the patient but also his/her family and environment is seriously affected by the disease and its consequences. Treatment and rehabilitation options for increasing or maintaining the quality of life of the affected patients are diverse, and significantly depend on the features of the health care system. The authors believe that the following review emphasizing health psychological principles may contribute to the work of professionals working in clinical and rehabilitational fields and through them may increase the quality of life of patients and their family. Orv. Hetil., 2015, 156(12), 472–478.

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Solriamfetol for Excessive Daytime Sleepiness in Parkinson's Disease: Phase 2 Proof‐of‐Concept Trial

Movement Disorders ◽

10.1002/mds.28702 ◽

2021 ◽

Author(s):

Aleksandar Videnovic ◽

Amy W. Amara ◽

Cynthia Comella ◽

Paula K. Schweitzer ◽

Helene Emsellem ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Excessive Daytime Sleepiness ◽

Daytime Sleepiness ◽

Phase 2 ◽

Proof Of Concept

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Changes in anatomical and functional connectivity of Parkinson's disease patients according to cognitive status

European Journal of Radiology ◽

10.1016/j.ejrad.2015.04.014 ◽

2015 ◽

Vol 84 (7) ◽

pp. 1318-1324 ◽

Cited By ~ 37

Author(s):

Boyu Chen ◽

Guo Guang Fan ◽

Hu Liu ◽

Shanshan Wang

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Functional Connectivity ◽

Cognitive Status

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Sleep, excessive daytime sleepiness and fatigue in Parkinson's disease

Journal of Neural Transmission - Parkinsons Disease and Dementia Section ◽

10.1007/bf02257678 ◽

1993 ◽

Vol 5 (3) ◽

pp. 235-244 ◽

Cited By ~ 131

Author(s):

J. J. Hilten ◽

M. Weggeman ◽

E. A. Velde ◽

G. A. Kerkhof ◽

J. G. Dijk ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Excessive Daytime Sleepiness ◽

Daytime Sleepiness

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Telerehabilitation in Parkinson's disease: Influence of cognitive status

Dementia & Neuropsychologia ◽

10.1590/s1980-5764-2016dn1004012 ◽

2016 ◽

Vol 10 (4) ◽

pp. 327-332 ◽

Cited By ~ 2

Author(s):

Alice Estevo Dias ◽

João Carlos Papaterra Limongi ◽

Wu Tu Hsing ◽

Egberto Reis Barbosa

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Status ◽

Disease Stage ◽

Voice Rehabilitation ◽

Voice Treatment ◽

Technological Competence ◽

Yahr Scale ◽

Invaluable Tool ◽

Remote Therapy

ABSTRACT Background: The need for efficacy in voice rehabilitation in patients with Parkinson's disease is well established. Given difficulties traveling from home to treatment centers, the use of telerehabilitation may represent an invaluable tool for many patients. Objective: To analyze the influence of cognitive performance on acceptance of telerehabilitation. Methods: Fifty patients at stages 2-4 on the Hoehn-Yahr scale, aged 45-87 years old, with cognitive scores of19-30 on the Mini-Mental State Examination, and 4-17 years of education were enrolled. All patients were submitted to evaluation of voice intensity pre and post in-person treatment with the Lee Silverman Voice Treatment (LSVT) and were asked to fill out a questionnaire regarding their preferences between two options of treatment and evaluating basic technological competence. Results: Comparisons between pre and post-treatment values showed a mean increase of 14dBSPL in vocal intensity. When asked about potential acceptance to participate in future telerehabilitation, 38 subjects agreed to take part and 12 did not. For these two groups, 26% and 17% self-reported technological competence, respectively. Agreement to engage in remote therapy was positively associated with years of education and cognitive status. Conclusion: Responses to the questionnaire submitted after completion of traditional in-person LSVT showed that the majority of patients (76%) were willing to participate in future telerehabilitation. Age, gender, disease stage and self-reported basic technological skills appeared to have no influence on the decision, whereas other factors such as cognitive status and higher school education were positively associated with acceptance of the new therapy approach.

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Elevated HDL Levels Linked to Poorer Cognitive Ability in Females With Parkinson’s Disease

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.656623 ◽

2021 ◽

Vol 13 ◽

Author(s):

Megan C. Bakeberg ◽

Anastazja M. Gorecki ◽

Jade E. Kenna ◽

Alexa Jefferson ◽

Michelle Byrnes ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Function ◽

Cognitive Performance ◽

Linear Models ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cognitive Status ◽

Cross Sectional ◽

Age Related

IntroductionCholesterol levels have been associated with age-related cognitive decline, however, such an association has not been comprehensively explored in people with Parkinson’s disease (PD). To address this uncertainty, the current cross-sectional study examined the cholesterol profile and cognitive performance in a cohort of PD patients.MethodsCognitive function was evaluated using two validated assessments (ACE-R and SCOPA-COG) in 182 people with PD from the Australian Parkinson’s Disease Registry. Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Triglyceride (TRG) levels were examined within this cohort. The influence of individual lipid subfractions on domain-specific cognitive performance was investigated using covariate-adjusted generalised linear models.ResultsFemales with PD exhibited significantly higher lipid subfraction levels (TC, HDL, and LDL) when compared to male counterparts. While accounting for covariates, HDL levels were strongly associated with poorer performance across multiple cognitive domains in females but not males. Conversely, TC and LDL levels were not associated with cognitive status in people with PD.ConclusionHigher serum HDL associates with poorer cognitive function in females with PD and presents a sex-specific biomarker for cognitive impairment in PD.

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