Magnetic Resonance Parkinsonism Index and midbrain to pons ratio: Which index better distinguishes Progressive Supranuclear Palsy patients with a low degree of diagnostic certainty from patients with Parkinson Disease?

AbstractNeuromelanin (NM) is a dark pigment that mainly exists in neurons of the substantia nigra pars compacta (SNc). In Parkinson disease (PD) patients, NM concentration decreases gradually with degeneration and necrosis of dopamine neurons, suggesting potential use as a PD biomarker. We aimed to evaluate associations between NM concentration in in vivo SN and PD progression and different motor subtypes using NM magnetic resonance imaging (NM-MRI). Fifty-four patients with idiopathic PD were enrolled. Patients were divided into groups by subtypes with different clinical symptoms: tremor dominant (TD) group and postural instability and gait difficulty (PIGD) group. Fifteen healthy age-matched volunteers were enrolled as controls. All subjects underwent clinical assessment and NM-MRI examination. PD patients showed significantly decreased contrast-to-noise ratio (CNR) values in medial and lateral SN (P < 0.05) compared to controls. CNR values in lateral SN region decreased linearly with PD progression (P = 0.001). PIGD patients showed significant decreases in CNR mean values in lateral SN compared to TD patients (P = 0.004). Diagnostic accuracy of using lateral substantia nigra (SN) in TD and PIGD groups was 79% (sensitivity 76.5%, specificity 78.6%). NM concentration in PD patients decreases gradually during disease progression and differs significantly between PD subtypes. NM may be a reliable biomarker for PD severity and subtype identification.

Download Full-text

Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy

NeuroSci ◽

10.3390/neurosci1020011 ◽

2020 ◽

Vol 1 (2) ◽

pp. 115-120

Author(s):

Jacques De Reuck ◽

Florent Auger ◽

Nicolas Durieux ◽

Claude-Alain Maurage ◽

Vincent Deramecourt ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Progressive Supranuclear Palsy ◽

Cerebral Amyloid Angiopathy ◽

Amyloid Angiopathy ◽

Post Mortem ◽

Resonance Imaging ◽

Cerebral Amyloid ◽

Magnetic Resonance Imaging Mri ◽

Neuropathological Examination

Introduction and Purpose: Cerebral amyloid angiopathy (CAA) can be observed in patients with progressive supranuclear palsy (PSP), though to a lesser degree than in Alzheimer’s disease. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) evaluates whether CAA has an influence on the degree of hippocampal atrophy (HA) and on the incidence of associated micro-infarcts (HMIs) and cortical micro-bleeds (HMBs). Material and Methods: Eight brains with PSP-CAA were compared to 20 PSP brains without CAA. In addition to the neuropathological examination, the hippocampus was evaluated on the most representative coronal section with T2 and T2*-weighted MRI sequences. The average degree of HA was determined in both groups. The incidence of HMIs and HMBs was also compared as well as the frequency of cortical micro-infarcts (CoMIs) and cortical micro-bleeds (CoMBs) in the hemispheric neocortex. Results: The neuropathological examination showed a higher incidence of lacunar infarcts in the PSP-CAA brains compared to the PSP ones. With magnetic resonance imaging (MRI), the severity of HA and the incidence of HMIs and HMBs was similar between both groups. Additionally, the frequency of CoMIs and CoMBs in the neocortex was comparable. Conclusions: The association of CAA in PSP brains has no influence on the degree of HA and on the incidence of the small cerebrovascular lesions in the hippocampus as well as in the neocortex.

Download Full-text

Corneal Sensitivity, Blink Rate, and Corneal Nerve Density in Progressive Supranuclear Palsy and Parkinson Disease

Cornea ◽

10.1097/ico.0b013e3182574ade ◽

2013 ◽

Vol 32 (5) ◽

pp. 631-635 ◽

Cited By ~ 39

Author(s):

Vandana C. Reddy ◽

Sanjay V. Patel ◽

David O. Hodge ◽

Jacqueline A. Leavitt

Keyword(s):

Parkinson Disease ◽

Progressive Supranuclear Palsy ◽

Blink Rate ◽

Corneal Sensitivity ◽

Corneal Nerve

Download Full-text

Magnetic resonance parkinsonism index in progressive supranuclear palsy and vascular parkinsonism

Neurological Sciences ◽

10.1007/s10072-016-2489-x ◽

2016 ◽

Vol 37 (4) ◽

pp. 591-595 ◽

Cited By ~ 15

Author(s):

Giovanni Mostile ◽

Alessandra Nicoletti ◽

Calogero Edoardo Cicero ◽

Tiziana Cavallaro ◽

Elisa Bruno ◽

...

Keyword(s):

Magnetic Resonance ◽

Progressive Supranuclear Palsy ◽

Vascular Parkinsonism

Download Full-text

Deuterium and phosphorus-31 nuclear magnetic resonance of cholesteryl palmitate in dipalmitoylphosphatidylcholine model membranes

Canadian Journal of Chemistry ◽

10.1139/v80-392 ◽

1980 ◽

Vol 58 (23) ◽

pp. 2433-2441 ◽

Cited By ~ 8

Author(s):

Robert J. Cushley ◽

Heiner Gorrissen ◽

Stephen R. Wassall

Keyword(s):

Nuclear Magnetic Resonance ◽

Magnetic Resonance ◽

Liquid Crystalline ◽

Acyl Chain ◽

Relaxation Times ◽

Average Diameter ◽

Low Degree ◽

Cholesteryl Palmitate ◽

Degree Of Order ◽

Ester Chain

Cholesteryl palmitate (CP) bas been incorporated into vesicles of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylcholine/20 mol% cholesterol, in amounts up to 5 mol%. By means of 31P lanthanide induced shifts the average diameter of these vesicles was calculated to be ~270 Å.The 2H spectral linewidths of selectively deuterated CP incorporated into liquid crystalline dipalmitoylphosphatidylcholine vesicles are ≤ 150 Hz, implying a low degree of order for the ester acyl chain. Addition of 20 mol% cholesterol to the vesicles increases the linewidths which, nevertheless, remain ≤ 185 Hz. The corresponding 2H longitudinal relaxation times (≤ 450 ms) indicate that the fast segmental motions of the ester chain are slower than for the phospholipid chains.

Download Full-text