scholarly journals Evaluation of mTHPC-loaded PLGA nanoparticles for in vitro photodynamic therapy on C6 glioma cell line

2019 ◽  
Vol 25 ◽  
pp. 448-455 ◽  
Author(s):  
G. Bœuf-Muraille ◽  
G. Rigaux ◽  
M. Callewaert ◽  
N. Zambrano ◽  
L. Van Gulick ◽  
...  
1990 ◽  
Vol 72 (5) ◽  
pp. 782-785 ◽  
Author(s):  
Justin D. Cohen ◽  
H. Ian Robins ◽  
Manucher J. Javid

✓ The cytotoxic, antiproliferative, and radiosensitizing effects of thymidine (a nucleoside metabolite) were studied using the C6 glioma cell line in vitro. Radiosensitization by a combination of thymidine and 41.8°C hyperthermia was also evaluated. Thymidine concentrations above 100 µg/ml completely inhibited C6 proliferation while concentrations of 100 to 1000 µg/ml (for up to 24 hours) decreased C6 cell survival to as little as 7.4% compared to untreated control cells. Radiosensitivity was enhanced by the administration of thymidine alone (400 µg/ml × 24 hours before irradiation); sensitization by 41.8°C hyperthermia alone (1 hour ending immediately before irradiation) was less pronounced. Thymidine and hyperthermia together produced greater radiosensitization than did heat alone or thymidine alone. These data support the further investigation of thymidine as a neuro-oncology radiosensitizer.


2013 ◽  
Vol 7 (1) ◽  
pp. 203-208 ◽  
Author(s):  
YONG ZHOU ◽  
YING XU ◽  
HAN WANG ◽  
JUNJIE NIU ◽  
HUAYING HOU ◽  
...  

Planta Medica ◽  
2013 ◽  
Vol 79 (16) ◽  
pp. 1516-1524 ◽  
Author(s):  
Ivica Jeremic ◽  
Vanja Tadic ◽  
Andjelka Isakovic ◽  
Vladimir Trajkovic ◽  
Ivanka Markovic ◽  
...  

1989 ◽  
Vol 48 (3) ◽  
pp. 359
Author(s):  
G. M. Zientek ◽  
A. Frankfurter ◽  
C. D. Katsetos ◽  
M. M. Herman

2009 ◽  
Vol 37 (2) ◽  
pp. 503-510 ◽  
Author(s):  
X-D Zhou ◽  
X-Y Wang ◽  
F-J Qu ◽  
Y-H Zhong ◽  
X-D Lu ◽  
...  

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