Efficacy of antimicrobial photodynamic therapy with chloro-aluminum phthalocyanine on periodontal clinical parameters and salivary GSH and MDA levels in patients with periodontitis

2020 ◽  
Vol 31 ◽  
pp. 101843
Author(s):  
Davi Neto de Araújo Silva ◽  
Natalia Teixeira da Silva ◽  
Israel Alexandre de Araújo Sena ◽  
Marcela Letícia da Silva Azevedo ◽  
Francisco Leonardo da Silva Júnior ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Parameters ◽  
Antimicrobial Photodynamic Therapy ◽  
Aluminum Phthalocyanine

Antimicrobial Photodynamic Therapy Using a Chloro-Aluminum Phthalocyanine Adjuvant to Nonsurgical Periodontal Treatment Does Not Improve Clinical Parameters in Patients with Chronic Periodontitis

2019 ◽  
Vol 37 (11) ◽  
pp. 729-735
Author(s):  
Israel Alexandre de Araújo Sena ◽  
Davi Neto de Araújo Silva ◽  
Marcela Letícia da Silva Azevedo ◽  
Natália Teixeira da Silva ◽  
João Paulo Figueiró Longo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Clinical Parameters ◽  
Antimicrobial Photodynamic Therapy ◽  
Aluminum Phthalocyanine

Effect of Hydrosoluble Chlorine–Mediated Antimicrobial Photodynamic Therapy on Clinical Parameters and Cytokine Profile in Ligature-Induced Periodontitis in Dogs

2013 ◽  
Vol 84 (6) ◽  
pp. 793-800 ◽  
Author(s):  
Parand Sorkhdini ◽  
Neda Moslemi ◽  
Shahram Jamshidi ◽  
Raika Jamali ◽  
Ali Akbar Amirzargar ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cytokine Profile ◽  
Clinical Parameters ◽  
Antimicrobial Photodynamic Therapy

scholarly journals Effects of Antimicrobial Photodynamic Therapy and Local Administration of Minocycline on Clinical, Microbiological, and Inflammatory Markers of Periodontal Pockets: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Takahiro Hokari ◽  
Toshiya Morozumi ◽  
Yasutaka Komatsu ◽  
Taro Shimizu ◽  
Toshiaki Yoshino ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Gingival Crevicular Fluid ◽  
Interleukin 1 ◽  
Interferon Γ ◽  
Local Administration ◽  
Clinical Parameters ◽  
Antimicrobial Photodynamic Therapy ◽  
Local Host ◽  
Crevicular Fluid ◽  
Clinical Trials Registry

Objective. We evaluated the efficacies of antimicrobial photodynamic therapy (aPDT) and minocycline ointment (MO) on clinical and bacteriological markers and the local host inflammatory response. Materials and Methods. A total of 30 patients with chronic periodontitis were randomly assigned to two groups. Selected periodontal pockets (probing depth 5–7 mm with bleeding on probing) were treated with aPDT or MO. Measurements of clinical parameters and the collection of gingival crevicular fluid (GCF) and subgingival plaque were performed at baseline, and at 1 and 4 weeks after treatment. Quantification of periodontopathic bacteria in the sulcus and a multiplex bead immunoassay of ten inflammatory cytokines in the GCF were performed. Results. Local MO administration exhibited a significant decrease in scores for clinical parameters (P<0.01) and a significant reduction in bacterial counts (P<0.01) and interleukin-1β and interferon-γ levels at 1 and 4 weeks after treatment (P<0.01). No significant changes were observed in the aPDT group, except in clinical parameters. Conclusions. Although our study had some limitations, we found that while local administration of MO may slightly help to improve clinical, microbiological, and crevicular cytokine levels in periodontal pockets, aPDT did not show any effects. This trial is registered with the UMIN Clinical Trials Registry UMIN000013376.

Antimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsions

2013 ◽  
Vol 30 (2) ◽  
pp. 549-559 ◽  
Author(s):  
Ana Paula Dias Ribeiro ◽  
Mariana Carvalho Andrade ◽  
Vanderlei Salvador Bagnato ◽  
Carlos Eduardo Vergani ◽  
Fernando Lucas Primo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Aluminum Phthalocyanine

Regenerative treatment of peri-implantitis following implant surface decontamination with titanium brush and antimicrobial photodynamic therapy: a case series with reentry

2020 ◽  
Author(s):  
Pier Poli ◽  
Francisley Avila Souza ◽  
Mattia Manfredini ◽  
Carlo Maiorana ◽  
Mario Beretta
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Case ◽  
Case Series ◽  
Antimicrobial Photodynamic Therapy ◽  
Implant Surface ◽  
Surface Decontamination

Not required for Clinical case letters according to the authors' guidelines.

scholarly journals Efficiency of Antimicrobial Photodynamic Therapy with Photodithazine® on MSSA and MRSA Strains

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 869
Author(s):  
Beatriz Müller Nunes Souza ◽  
Juliana Guerra Pinto ◽  
André Henrique Correia Pereira ◽  
Alejandro Guillermo Miñán ◽  
Juliana Ferreira-Strixino
Keyword(s):  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Antimicrobial Photodynamic Therapy ◽  
Bacterial Inactivation ◽  
Bacterial Reduction ◽  
Complete Inactivation ◽  
Opportunistic Bacteria ◽  
Significant Difference ◽  
Mrsa Strains

Staphylococccus aureus is a ubiquitous and opportunistic bacteria associated with high mortality rates. Antimicrobial photodynamic therapy (aPDT) is based on the application of a light source and a photosensitizer that can interact with molecular oxygen, forming Reactive Oxygen Species (ROS) that result in bacterial inactivation. This study aimed to analyze, in vitro, the action of aPDT with Photodithazine® (PDZ) in methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) strains. The strains were incubated with PDZ at 25, 50, 75, and 100 mg/L for 15 min and irradiated with fluences of 25, 50, and 100 J/cm2. The internalization of PDZ was evaluated by confocal microscopy, the bacterial growth by counting the number of colony-forming units, as well as the bacterial metabolic activity post-aPDT and the production of ROS. In both strains, the photosensitizer was internalized; the production of ROS increased when the aPDT was applied; there was a bacterial reduction compared to the control at all the evaluated fluences and concentrations; and, in most parameters, it was obtained complete inactivation with significant difference (p < 0.05). The implementation of aPDT with PDZ in clinical strains of S. aureus has resulted in its complete inactivation, including the MRSA strains.

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