The article contains some data from modern literature on the problems of the course and tactics of managing of manifested forms of human papillomavirus infection (HPI) in pregnant women. The following variants of clinical forms of HPI, such as intraepithelial neoplasia, genital warts, and respiratory papillomatosis in children are analyzed. The authors also characterized permissible during pregnancy methods of treatment, including diathermocoagulation, surgical excision, radio wave destruction, photodynamic therapy, chemical destruction, as well as the possibility of immunotherapy. The necessity of correcting immunological disorders, treatment of concomitant infections of the urogenital tract and the importance of examination of a sexual partner are emphasized.