scholarly journals The Impact of Atrial Left-to-Right Shunt on Pulmonary Hypertension in Preterm Infants with Moderate or Severe Bronchopulmonary Dysplasia

2015 ◽  
Vol 56 (5) ◽  
pp. 317-323 ◽  
Author(s):  
Eui Kyung Choi ◽  
Young Hwa Jung ◽  
Han-Suk Kim ◽  
Seung Han Shin ◽  
Chang Won Choi ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
The Impact

scholarly journals The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year

2018 ◽  
Vol 203 ◽  
pp. 218-224.e3 ◽  
Author(s):  
Joanne M. Lagatta ◽  
Erik B. Hysinger ◽  
Isabella Zaniletti ◽  
Erica M. Wymore ◽  
Shilpa Vyas-Read ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
The Impact

scholarly journals Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System

Cells ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1875
Author(s):  
Cho-Ming Chao ◽  
Lei Chong ◽  
Xuran Chu ◽  
Amit Shrestha ◽  
Judith Behnke ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Signaling Pathway ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Potential Role ◽  
Vascular System ◽  
Point Of View ◽  
Pulmonary Vasculature ◽  
Curative Therapy

More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.

scholarly journals Pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infants

2017 ◽  
Vol 124 ◽  
pp. 21-29 ◽  
Author(s):  
Christine B. Bui ◽  
Merrin A. Pang ◽  
Arvind Sehgal ◽  
Christiane Theda ◽  
Jason C. Lao ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

Pulmonary Hypertension in Preterm Infants: Prevalence and Association with Bronchopulmonary Dysplasia

2014 ◽  
Vol 165 (5) ◽  
pp. 909-914.e1 ◽  
Author(s):  
Hussnain Mirza ◽  
James Ziegler ◽  
Sara Ford ◽  
James Padbury ◽  
Richard Tucker ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

Persistent pulmonary hypertension of the newborn in extremely preterm infants: a Japanese cohort study

2018 ◽  
Vol 103 (6) ◽  
pp. F554-F561 ◽  
Author(s):  
Hidehiko Nakanishi ◽  
Hideyo Suenaga ◽  
Atsushi Uchiyama ◽  
Satoshi Kusuda
Keyword(s):  
Pulmonary Hypertension ◽  
Cohort Study ◽  
Preterm Infants ◽  
Research Network ◽  
Persistent Pulmonary Hypertension ◽  
Neurodevelopmental Outcomes ◽  
Significant Independent Risk Factor ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
The Impact

ObjectiveTo investigate the characteristics of persistent pulmonary hypertension of the newborn (PPHN) in extremely preterm infants and its impact on neurodevelopmental outcomes at 3 years of age.DesignA retrospective multicentre cohort study.Settings202 tertiary perinatal centres registered in the Neonatal Research Network of Japan (NRNJ).PatientsInfants born at <28 weeks of gestational age (GA), between 2003 and 2012, were extracted from tertiary perinatal centres participating in NRNJ.Main outcome measuresDemographic characteristics, morbidity, interventions and mortality were compared for infants with and without PPHN. Multivariable logistic analysis was performed to evaluate the impact of PPHN on long-term neurodevelopmental outcomes (the prevalence rate of cerebral palsy, need for home oxygen therapy, and visual, hearing and cognitive impairment) at 3 years of age.ResultsThe prevalence of PPHN among the 12 954 extremely preterm infants enrolled was 8.1% (95% CI 7.7% to 8.6%), with the trend increasing annually, and a higher proportion as GA decreased: 18.5% (range, 15.2% to 22.4%) for infants born at 22 weeks compared with 4.4% (range, 3.8% to 5.2%) for those born at 27 weeks. Clinical chorioamnionitis and premature rupture of membranes were associated with PPHN. On multivariate analysis of the data from 5923 infants followed up for 3 years, PPHN was a significant independent risk factor for visual impairment (adjusted OR, 1.42, 95% CI 1.03 to 1.97).ConclusionsThe prevalence of PPHN in extremely preterm infants has been increasing over the past decade in Japan. Clinicians should be aware of visual impairments as a neurodevelopmental abnormality among infants with PPHN.

scholarly journals Pulmonary Hypertension in Preterm Infants with Bronchopulmonary Dysplasia

2014 ◽  
Vol 27 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Christopher D. Baker ◽  
Steven H. Abman ◽  
Peter M. Mourani
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia

scholarly journals Clinical and functional features of the small circle of blood circulation in children with a new form of bronchopulmonary dysplasia

2021 ◽  
Vol 24 (5) ◽  
pp. 292-299
Author(s):  
Milana A. Basargina ◽  
Andrey P. Fisenko ◽  
Irina V. Davydova ◽  
Maksim V. Kondratyev ◽  
Anastasiya S. Petrova ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Group Discussion ◽  
Right Heart ◽  
Functional Features ◽  
Reliable Marker ◽  
The Right ◽  
Gestational Age At Birth ◽  
Age At Birth

The aim of the work is to analyze the data of Echo-CG examination of premature infants who have formed and have not formed bronchopulmonary dysplasia (BPD) to determine the frequency of the formation of pulmonary hypertension (PH). Materials and methods. A total of 199 preterm infants treated in the Department of Pathology of Newborns were examined. The first group included moderate and severe BPD children (n = 117; 59%). The second group consisted of children without BPD within clearly decreed terms (n = 82; 41%). In each group, patients were divided into four subgroups by the gestational age at birth and the timing of the Echo-CG. Results. Only two (1.1%) patients out of 117 BPD children of the first group were diagnosed with pulmonary hypertension (PH). In 3 (2.5%) of 117 infants of the same group, enlargement of the right heart without PH was revealed. Out of 82 children without BPD, two patients had signs of right heart enlargement. PH was not diagnosed in any of the patients in this group. Discussion. To aggravate the efficiency of PH diagnosis, a number of indices of screening echocardiography seem to be increased by additional analysis of changes in the systolic eccentricity index (EI), as a reliable marker of PH in BPD children. Systolic IE should be integrated into screening in preterm infants for the diagnosis of PH. The use of Echo-CG data along with analysis of blood BNP or NT-proBNP blood content be also expanded. Optimizing the diagnosis of PH at the early stages of BPD is necessary to increase the efficacy of targeted therapy and reduce the risk of severe complications of BPD.

scholarly journals Diminished right ventricular function at diagnosis of pulmonary hypertension is associated with mortality in bronchopulmonary dysplasia

2019 ◽  
Vol 9 (3) ◽  
pp. 204589401987859 ◽  
Author(s):  
Gabriel Altit ◽  
Shazia Bhombal ◽  
Jeffrey Feinstein ◽  
Rachel K. Hopper ◽  
Theresa A. Tacy
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Bronchopulmonary Dysplasia ◽  
Pulmonary Vascular Disease ◽  
Cox Proportional Hazard ◽  
Hazard Ratios ◽  
Peak Longitudinal Strain ◽  
Gestational Age At Birth ◽  
The Impact

Pulmonary vascular disease and resultant pulmonary hypertension (PH) have been increasingly recognized in the preterm population, particularly among patients with bronchopulmonary dysplasia (BPD). Limited data exist on the impact of PH severity and right ventricular (RV) dysfunction at PH diagnosis on outcome. The purpose of this study was to evaluate if echocardiography measures of cardiac dysfunction and PH severity in BPD-PH were associated with mortality. The study is a retrospective analysis of the echocardiography at three months or less from time of PH diagnosis. Survival analysis using a univariate Cox proportional hazard model is presented and expressed using hazard ratios (HR). We included 52 patients with BPD and PH of which 16 (31%) died at follow-up. Average gestational age at birth was 26.3 ± 2.3 weeks. Echocardiography was performed at a median of 43.3 weeks (IQR: 39.0–54.7). The median time between PH diagnosis and death was 117 days (range: 49–262 days). Multiple measures of PH severity and RV performance were associated with mortality (sPAP/sBP: HR 1.02, eccentricity index: HR 2.02, tricuspid annular plane systolic excursion Z-score: HR 0.65, fractional area change: HR 0.88, peak longitudinal strain: HR 1.22). Hence, PH severity and underlying RV dysfunction at PH diagnosis were associated with mortality in BPD-PH patients. While absolute estimation of pulmonary pressures is not feasible in every screening echocardiography, thorough evaluation of RV function and other markers of PH may allow to discriminate the most at-risk population and should be considered as standard add-ons to the current screening at 36 weeks.

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