Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases

Peptides ◽  
2014 ◽  
Vol 60 ◽  
pp. 102-106 ◽  
Author(s):  
Marta Sobczak ◽  
Andrzej Pilarczyk ◽  
Mateusz Jonakowski ◽  
Agata Jarmuż ◽  
Maciej Sałaga ◽  
...  
2020 ◽  
Vol 21 (8) ◽  
pp. 2940
Author(s):  
Antonelly Cassio Alves de Carvalho ◽  
Gabriela Achete de Souza ◽  
Samylla Vaz de Marqui ◽  
Élen Landgraf Guiguer ◽  
Adriano Cressoni Araújo ◽  
...  

Inflammatory bowel diseases (IBD) are characterized by a chronic and recurrent gastrointestinal condition, including mainly ulcerative colitis (UC) and Crohn’s disease (CD). Cannabis sativa (CS) is widely used for medicinal, recreational, and religious purposes. The most studied compound of CS is tetrahydrocannabinol (THC) and cannabidiol (CBD). Besides many relevant therapeutic roles such as anti-inflammatory and antioxidant properties, there is still much controversy about the consumption of this plant since the misuse can lead to serious health problems. Because of these reasons, the aim of this review is to investigate the effects of CS on the treatment of UC and CD. The literature search was performed in PubMed/Medline, PMC, EMBASE, and Cochrane databases. The use of CS leads to the improvement of UC and CD scores and quality of life. The medical use of CS is on the rise. Although the literature shows relevant antioxidant and anti-inflammatory effects that could improve UC and CD scores, it is still not possible to establish a treatment criterion since the studies have no standardization regarding the variety and part of the plant that is used, route of administration and doses. Therefore, we suggest caution in the use of CS in the therapeutic approach of IBD until clinical trials with standardization and a relevant number of patients are performed.


2019 ◽  
Vol 31 (3) ◽  
pp. e13531 ◽  
Author(s):  
Luna Carpinelli ◽  
Cristina Bucci ◽  
Antonella Santonicola ◽  
Fabiana Zingone ◽  
Carolina Ciacci ◽  
...  

2020 ◽  
Vol 40 (2) ◽  
pp. 99-104
Author(s):  
Rafaela dos Santos Dilly ◽  
Claiza Barretta ◽  
Cristina Henschel Matos ◽  
Bárbara Tortato Piasecki ◽  
Bruno Lorenzo Scolaro ◽  
...  

2021 ◽  
Author(s):  
jingjing Mu ◽  
jingwen xu ◽  
linlin wang ◽  
Caifa Chen ◽  
Ping Chen

The purple sweet potato anthocyanin has been acknowledged for its beneficial effects on human inflammatory bowel diseases (IBD). Although the ability of anthocyanin in modulating gut microbiota has been reported,...


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