Regulation of insulin sensitivity, insulin production, and pancreatic β cell survival by angiotensin-(1-7) in a rat model of streptozotocin-induced diabetes mellitus

Peptides ◽  
2015 ◽  
Vol 64 ◽  
pp. 49-54 ◽  
Author(s):  
Junhua He ◽  
Zhiming Yang ◽  
Huiyu Yang ◽  
Li Wang ◽  
Huilu Wu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Cell Survival ◽  
Rat Model ◽  
Pancreatic Β Cell ◽  
Insulin Production ◽  
Β Cell ◽  
Streptozotocin Induced Diabetes

Phenolic-enriched blueberry-leaf extract attenuates glucose homeostasis, pancreatic β-cell function, and insulin sensitivity in high-fat diet–induced diabetic mice

2020 ◽  
Vol 73 ◽  
pp. 83-96 ◽  
Author(s):  
Hua Li ◽  
Hye-Mi Park ◽  
Hyeon-Seon Ji ◽  
Jisu Han ◽  
Sang-Kyum Kim ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Homeostasis ◽  
High Fat Diet ◽  
Leaf Extract ◽  
Cell Function ◽  
Pancreatic Β Cell ◽  
Diabetic Mice ◽  
High Fat ◽  
Β Cell ◽  
Β Cell Function

scholarly journals Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus

2021 ◽  
Author(s):  
Jing Yong ◽  
James D. Johnson ◽  
Peter Arvan ◽  
Jaeseok Han ◽  
Randal J. Kaufman
Keyword(s):  
Diabetes Mellitus ◽  
Er Stress ◽  
Pancreatic Β Cell ◽  
Β Cell

Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell

Endocrine ◽  
2013 ◽  
Vol 44 (2) ◽  
pp. 369-379 ◽  
Author(s):  
Souvik Roy ◽  
Satyajit Kumar Metya ◽  
Santanu Sannigrahi ◽  
Noorjaman Rahaman ◽  
Faiqa Ahmed
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Inflammatory Cytokines ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Streptozotocin Induced Diabetes ◽  
Pro Inflammatory Cytokines

Stem cells for pancreatic β-cell replacement in diabetes mellitus

2014 ◽  
Vol 19 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Riccardo Calafiore ◽  
Pia Montanucci ◽  
Giuseppe Basta
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Replacement

scholarly journals Insulin sensitivity and β-cell function in normoglycemic offspring of individuals with type 2 diabetes mellitus: Impact of line of inheritance

2012 ◽  
Vol 16 (1) ◽  
pp. 105 ◽  
Author(s):  
AriacheryC Ammini ◽  
SadaNand Dwivedi ◽  
Nandita Gupta ◽  
Rajesh Khadgawat ◽  
MadanL Khurana ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Β Cell ◽  
Β Cell Function

Hesperidin ameliorates pancreatic β-cell dysfunction and apoptosis in streptozotocin-induced diabetic rat model

Life Sciences ◽  
2019 ◽  
Vol 235 ◽  
pp. 116858 ◽  
Author(s):  
Wanthanee Hanchang ◽  
Aree Khamchan ◽  
Navinee Wongmanee ◽  
Chananchida Seedadee
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Cell Dysfunction ◽  
Diabetic Rat Model

Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children

2019 ◽  
Vol 74 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Ting Chen ◽  
Fengyun Wang ◽  
Zhenyu Chu ◽  
Ling Sun ◽  
Haitao Lv ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Insulinogenic Index ◽  
Model Assessment ◽  
Pancreatic Β Cell ◽  
Obese Children ◽  
Β Cell ◽  
Β Cell Function ◽  
Obese Subjects

Objectives: Spexin (SPX) is a novel peptide that has recently emerged as an important regulatory adipokine of obesity and related metabolic disease. Little is known about its role in children. The aim of the current study was to determine the potential role of SPX in obese children and explore its relationships with obesity-related markers, insulin sensitivity and pancreatic β cell function. Method: We studied the levels of serum SPX in 40 obese and 32 normal weight pre-puberty children (mean age was 8.59 ± 1.82 and 8.15 ± 2.03 years in obesity and control groups respectively). We investigated the levels of body mass index, blood pressure, lipids, glucose, insulin, Homeostasis model assessment for insulin-resistant (HOMA-IR, HOMA for β-cell function [HOMA-β]), insulinogenic index and C-peptide index and analyzed their correlations with SPX levels. Results: SPX levels were significantly decreased in obese children compared to controls. Moreover, serum SPX levels were lower in IR obese subjects in contrast with the non-IR obese subjects. Serum SPX concentrations correlated negatively and significantly with triglycerides, systolic blood pressure, diastolic blood pressure, fasting insulin level, HOMA-IR, insulinogenic index, and HOMA-β levels in obese children. Conclusions: In summary, serum SPX levels significantly decreased in obese children and negatively correlated with insulin resistance and pancreatic β cell function indicators. Therefore, SPX may play a protective role in the process of glucose homeostasis and is closely related to β cell function in obese children.

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