A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control

2016 ◽  
Vol 111 ◽  
pp. 272-282 ◽  
Author(s):  
Luis E. Simental-Mendía ◽  
Amirhossein Sahebkar ◽  
Martha Rodríguez-Morán ◽  
Fernando Guerrero-Romero
Keyword(s):  
Systematic Review ◽  
Insulin Sensitivity ◽  
Randomized Controlled Trials ◽  
Glucose Control ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Magnesium Supplementation ◽  
Randomized Controlled

Effects of Melatonin Supplementation on Insulin Levels and Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2021 ◽  
Vol 53 (09) ◽  
pp. 616-624
Author(s):  
Yan Li ◽  
Zhenbin Xu
Keyword(s):  
Systematic Review ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Model Assessment ◽  
Insulin Levels ◽  
Randomized Controlled

AbstractInsulin resistance (IR) is a pivotal process in various metabolic diseases. The well-known treatment is lifestyle modification and medication therapy, which may result in poor compliance and side effects. Melatonin has been suggested to have a role in glucose metabolism, yet the results across studies have been inconsistent. Therefore, we performed a systematic review to evaluate the effects of melatonin supplementation on insulin levels and IR. We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov, and identified randomized controlled trials (RCTs) published prior to August 2020. Articles were reviewed, selected and extracted by two reviewers independently. In total, 8 RCTs of 376 participants were included. Data were pooled using a random-effects model, with mean differences (MDs) and 95% confidence intervals (CIs). Our results showed that melatonin administration significantly reduced insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR), and increased the quantitative insulin sensitivity check index (QUICKI). We conclude that melatonin ameliorated hyperinsulinemia, insulin resistance, and insulin sensitivity, and the results are an update of a previous meta-analysis. Although more investigations are required, we clearly provide evidence for the use of melatonin as an adjuvant treatment for metabolic disorders involving IR.

Effects of Oral Magnesium Supplementation on Vascular Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2019 ◽  
Vol 27 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Bianca Cristina Antunes Alves Marques ◽  
Márcia Regina Simas Torres Klein ◽  
Michelle Rabello da Cunha ◽  
Samanta de Souza Mattos ◽  
Lívia de Paula Nogueira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Vascular Function ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Magnesium Supplementation ◽  
Randomized Controlled ◽  
Oral Magnesium
Sign in / Sign up

Export Citation Format

Share Document