Dysregulation of Non-coding RNAs mediates Cisplatin Resistance in Hepatocellular Carcinoma and therapeutic strategies

2021 ◽  
pp. 105906
Author(s):  
Xu-feng Xu ◽  
Xiao-ke Yang ◽  
Yang Song ◽  
Bang-jie Chen ◽  
Xiao Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cisplatin Resistance ◽  
Therapeutic Strategies ◽  
Non Coding Rnas

Long non‐coding RNAs (CASC2 and TUG1) in hepatocellular carcinoma: Clinical significance

2019 ◽  
Vol 21 (9) ◽  
Author(s):  
Noha S. Refai ◽  
Manal L. Louka ◽  
Hany Y. Halim ◽  
Iman Montasser
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Significance ◽  
Non Coding Rnas

scholarly journals MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3026
Author(s):  
Hyuk Moon ◽  
Simon-Weonsang Ro
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signaling Pathway ◽  
Molecular Mechanisms ◽  
Therapeutic Strategies ◽  
Erk Signaling ◽  
Health Concern ◽  
Alternative Mechanism ◽  
Major Health ◽  
Activating Mutations ◽  
Genetic Events

Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF genes are rarely found in HCC, which are major genetic events leading to the activation of the MAPK/ERK signaling pathway in other cancers. This suggests that there is an alternative mechanism behind the activation of the signaling pathway in HCC. Here, we will review recent advances in understanding the cellular and molecular mechanisms involved in the activation of the MAPK/ERK signaling pathway and discuss potential therapeutic strategies targeting the signaling pathway in the context of HCC.

scholarly journals Long non-coding RNAs and hepatocellular carcinoma

2014 ◽  
Vol 3 (1) ◽  
pp. 13-17 ◽  
Author(s):  
FU-JUN YU ◽  
JIAN-JIAN ZHENG ◽  
PEI-HONG DONG ◽  
XIAO-MING FAN
Keyword(s):  
Hepatocellular Carcinoma ◽  
Non Coding Rnas

scholarly journals Long Non-Coding RNAs: Potential Biomarkers and Targets for Hepatocellular Carcinoma Therapy and Diagnosis

2021 ◽  
Vol 17 (1) ◽  
pp. 220-235
Author(s):  
Donghong Yuan ◽  
Yu Chen ◽  
Xiaobing Li ◽  
Jing Li ◽  
Yueshui Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Non Coding Rnas ◽  
Therapy And Diagnosis ◽  
Potential Biomarkers

Vascular microinvasion from hepatocellular carcinoma: CT findings and pathologic correlation for the best therapeutic strategies

2017 ◽  
Vol 34 (5) ◽  
Author(s):  
Alfonso Reginelli ◽  
Angelo Vanzulli ◽  
Cristiano Sgrazzutti ◽  
Luca Caschera ◽  
Nicola Serra ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Strategies ◽  
Pathologic Correlation ◽  
Ct Findings

scholarly journals Landscape of associations between long non‐coding RNAs and infiltrating immune cells in liver hepatocellular carcinoma

2020 ◽  
Vol 24 (19) ◽  
pp. 11243-11253 ◽  
Author(s):  
Li Li ◽  
Xiaowei Song ◽  
Yanju Lv ◽  
Qiuying Jiang ◽  
Chengjuan Fan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Cells ◽  
Non Coding Rnas ◽  
Liver Hepatocellular Carcinoma

scholarly journals Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

2019 ◽  
Vol 79 (17) ◽  
pp. 4326-4330 ◽  
Author(s):  
Mark Yarchoan ◽  
Parul Agarwal ◽  
Augusto Villanueva ◽  
Shuyun Rao ◽  
Laura A. Dawson ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Strategies ◽  
Recent Developments
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