Main active components of Si-Miao-Yong-An decoction (SMYAD) attenuate autophagy and apoptosis via the PDE5A-AKT and TLR4-NOX4 pathways in isoproterenol (ISO)-induced heart failure models

2022 ◽  
pp. 106077
Author(s):  
Minru Liao ◽  
Yuqian Zhao ◽  
Qiang Xie ◽  
Chengcan Yang ◽  
Congcong Lin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Active Components ◽  
Failure Models

Production of Swine Myocardial Infarction and Ischemic Heart Failure Models Using a Three-Dimensional Bioprinted Occluder

2020 ◽  
Author(s):  
Han Byul Kim ◽  
Seungman Jung ◽  
Hyukjin Park ◽  
Doo sun Sim ◽  
Moon Ki Kim ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Three Dimensional ◽  
Ischemic Heart ◽  
Ischemic Heart Failure ◽  
Failure Models

Heart Failure Models: Traditional and Novel Therapy

2015 ◽  
Vol 13 (5) ◽  
pp. 658-669 ◽  
Author(s):  
Mohamed Haidara ◽  
Abdullah Assiri ◽  
Hanaa Yassin ◽  
Hania Ammar ◽  
Milan Obradovic ◽  
...  
Keyword(s):  
Heart Failure ◽  
Novel Therapy ◽  
Failure Models

Comparative study on the main active components of Baoyuan Decoction in plasma and urine of normal and heart failure rats

2021 ◽  
Author(s):  
Ying‐Yuan Lu ◽  
Meng Fang ◽  
Zhi‐Yong Du ◽  
Jin‐Long Wang ◽  
Jin‐Yang Song ◽  
...  
Keyword(s):  
Heart Failure ◽  
Comparative Study ◽  
Active Components

scholarly journals Cardiotonic effect of a new positive inotropic agent, OPC-8212, on canine right-sided heart failure models

1984 ◽  
Vol 36 ◽  
pp. 276
Author(s):  
Keitaro Hashimoto ◽  
Toyoki Mori ◽  
Shuji Yamashita ◽  
Youichi Yabuuchi
Keyword(s):  
Heart Failure ◽  
Inotropic Agent ◽  
Failure Models ◽  
Cardiotonic Effect

Real-Time Three-Dimensional Echocardiography To Quantify Remodeling after Infarction in Ovine Heart Failure Models

2006 ◽  
Vol 12 (6) ◽  
pp. S19
Author(s):  
Liam P. Ryan ◽  
Hirotsugu Hamamoto ◽  
Benjamin M. Jackson ◽  
Landi M. Parish ◽  
Martin G. St. John Sutton ◽  
...  
Keyword(s):  
Heart Failure ◽  
Real Time ◽  
Three Dimensional ◽  
Failure Models ◽  
Dimensional Echocardiography ◽  
Three Dimensional Echocardiography

Cardiovascular safety evaluations assessment in exercise stress and heart failure models

2008 ◽  
Vol 58 (2) ◽  
pp. 160
Author(s):  
Craig R. Hassler ◽  
Matthew Coffee ◽  
Michael Hawk ◽  
Michael Stonerook ◽  
Matthew Ellinger ◽  
...  
Keyword(s):  
Heart Failure ◽  
Exercise Stress ◽  
Cardiovascular Safety ◽  
Failure Models

scholarly journals Discussion on the Mechanism of Action of High-frequency Drugs for Treating Heart Failure Based on Network Pharmacology

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Feifei Lei ◽  
Mingjun Zhao ◽  
Haifang Wang ◽  
Chao Pan ◽  
Xiaoya Shi
Keyword(s):  
Heart Failure ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Salvia Miltiorrhiza ◽  
Network Pharmacology ◽  
Active Components ◽  
Radix Astragalus ◽  
Pharmacological Studies ◽  
Chinese Medicine Treatment

Objective: To explore the target and mechanism of Astragalus membranaceus, poria, salvia miltiorrhiza and semen leiocarpa in the treatment of heart failure by network pharmacology. Methods: The active components of traditional Chinese medicine and the target of heart failure were screened by multi-platform, and the standard gene was transformed by Uniprot. CytoCasp 3.6.1 was used to draw the network diagram of traditional Chinese medicine - component - target. Go and KEGG analysis were performed by Metascape. Results: A total of 36 predictive target sites of Radix Astragalus, Fuling poria, Salvia miltiorrhiza and Draba nemorosa were screened for treatment of heart failure, mainly involving nerve and factor pathways: ADRB2, ADRA1B and AChE. Cancer pathway: TP53, TNF; Pathways of inflammation: IL1B, PTSG2, PTSG1; Sex hormone pathway: ESR1, AR, PGR; Others: SCN5A, HIF1A, etc. The results of GO and KEGG enrichment suggested that the treatment of heart failure with the top four drugs involved cancer pathway, calcium signaling pathway, HIF-1 signaling pathway, and involved in blood circulation, cell proliferation and other processes. Conclusion: This study combines the pharmacological studies of Chinese medicine and western medicine to reveal the mechanism of multi-target and multi-channel regulation of body balance in Chinese medicine treatment.

scholarly journals Effect of RGOs on the Efficacy of Nkx2.5 Transfected Bone Marrow Mesenchymal Stem Cells Transplantation in Treatment Heart Failure in Rats

2020 ◽  
Author(s):  
Lin Wang ◽  
Bo Deng ◽  
Ran Zhang ◽  
Xingxing Hu ◽  
Yang Li ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synergistic Effect ◽  
Volume Fraction ◽  
Left Ventricular ◽  
Collagen I ◽  
Failure Models ◽  
Tgf Β1

Abstract Background: Heart failure (HF) is one of the major serious diseases to do harm to human health. Drugs, interventional treatment and heart transplantation are currently the main methods to treat HF. However, they fail to improve the patient's condition. Mesenchymal stem cells (MSCs) can regenerate functional cardiomyocytes and are promising to become a new therapeutic measure to treat heart failure. We assumed that Rehmannia glutinosa oligosaccharide (RGOs) has the synergistic effect with Nkx2.5 transfected MSCs (Nkx2.5) transplantation in treatment heart failure. Methods: MSCs and Nkx2.5 were preconditioned by RGOs. The apoptosis rate was detected by flow cytometry and the expressions of cardiac specific genes were analyzed with quantitative real-time PCR and Western blot in vitro. Heart failure models were duplicated by injecting doxorubicin (total dose of 15mg/kg) intraperitoneally in male SD rats. When the models were prepared, rats were randomly divided into 6 groups: Control (CON), HF, MSCs, Nkx2.5, RGOs and RGOs combined with Nkx2.5 (RGOs+Nkx2.5) group. Echocardiography was used to detect cardiac function in rats. HE staining was used to observe the pathological changes of myocardium, and Masson staining was used to calculate the collagen volume fraction to detect the degree of myocardial fibrosis. The total mRNA was extracted to detect the following genes including cTnI, CX43, TGF-β1, Collagen I, MEF2 and GATA4 by Q-PCR. Protein of myocardial tissue was extracted to detect the expression of cTnI, CX43, MEF2 and GATA4, by western blot. Results: RGOs could not enhance cardiac specific gene expressions including CK, α-MHC, however it improved the survival of Nkx2.5 induced by H2O2 in vitro. In rat heart failure models, RGOs alone improved the heart pumping function and decreased collagen volume fraction (CVF), TGF-β1 and collagen I expression, and increased MEF2 and GATA4 mRNA expression. Moreover, RGOs cooperated with Nkx2.5 in improving left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV). Furthermore, RGOs and Nkx2.5 combination also increased CX43 expression, whereas decreased CVF and collagen I expression. Conclusion: RGOs has the synergistic effect with Nkx2.5 gene transfected MSCs transplantation in treatment with heart failure through decreasing myocardial fibrosis, inhibiting ventricular remodeling, and increasing the expressions of GATA4, MEF2.

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