Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory

2010 ◽  
Vol 99 (3) ◽  
pp. 334-342 ◽  
Author(s):  
Kate S. Collison ◽  
Nadine J. Makhoul ◽  
Angela Inglis ◽  
Mohammed Al-Johi ◽  
Marya Zia Zaidi ◽  
...  
2011 ◽  
Vol 7 (2) ◽  
pp. 265-280 ◽  
Author(s):  
Kate S. Collison ◽  
Marya Z. Zaidi ◽  
Soad M. Saleh ◽  
Nadine J. Makhoul ◽  
Angela Inglis ◽  
...  

BMC Genomics ◽  
2011 ◽  
Vol 12 (1) ◽  
Author(s):  
Kate S Collison ◽  
Marya Z Zaidi ◽  
Zakia Maqbool ◽  
Soad M Saleh ◽  
Angela Inglis ◽  
...  

2013 ◽  
Vol 10 (1) ◽  
pp. 44 ◽  
Author(s):  
Kate S Collison ◽  
Nadine J Makhoul ◽  
Marya Z Zaidi ◽  
Angela Inglis ◽  
Bernard L Andres ◽  
...  

2021 ◽  
Author(s):  
Faizal Muhammad

The toxicity of monosodium glutamate (MSG) at high concentration has become a controversial issue because of its inconsistent results in human and animal studies. This study aims to investigate the effects of subchronic high doses oral administration of MSG on the spatial memory and the estimated total number of the hippocampal pyramidal cells. This study involved twenty-eight male Wistar rats which were divided into control group and 3 intervention groups (1.0 mg/g body weight, 2.0 mg/g body weight, and 4.0 mg/g body weight) of MSG for 30 days. The estimated number of hippocampal pyramidal cells in the Cornu Ammonis (CA) region including CA1 and CA2-CA3 regions and the data of spatial memory were analyzed using ANOVA test. This study implemented stereological procedures and the precision was evaluated using the formula. The dose of 4 mg/g body weight MSG caused a significant decrease (p = 0.004) in the estimated number of pyramidal cells in CA1, but not in the CA2-CA3 of hippocampus (p = 0.173). The CA1 region were more vulnerable to glutamate excitotoxicity than those in the CA2-CA3 region. The present study has provided novel quantitative data that subchronic high dose of MSG caused deleterious effects on the hippocampal CA1 pyramidal cells and memory consolidation.


2002 ◽  
Vol 18 (1) ◽  
pp. 63-77 ◽  
Author(s):  
Anastasia Efklides ◽  
Efterpi Yiultsi ◽  
Theopisti Kangellidou ◽  
Fotini Kounti ◽  
Fotini Dina ◽  
...  

Summary: The Wechsler Memory Scale (WMS) is a laboratory-based memory test that has been criticized for its lack of ecological validity and for not testing long-term memory. A more recent memory test, which aims at testing everyday memory, is the Rivermead Behavioral Memory Test (RBMT); it tests prospective memory and other forms of memory not tapped by WMS. However, even this test does not capture all aspects of everyday memory problems often reported by adults. These problems are the object of the Everyday Memory Questionnaire (EMQ). This study aimed at identifying the relationships between these three memory tests. The differential effect of Alzheimer's disease (AD) on the above relationships was also studied. The sample consisted of 233 healthy adults (20 to 75+ years of age) and 39 AD patients (50 to 75 years of age). Confirmatory factor analysis revealed the following latent factors: Verbal Memory, Visual Reconstruction, Orientation, Message (action embedded in spatial context), Visual Recognition, Spatial Memory, New Learning/Association Forming, Prospective/Episodic Memory, and Metamemory. These first-order factors were further explained by two second-order factors: Semantic Memory and Coordination of Semantic and Visuo-Spatial Memory. This basic structure was preserved in the sample of AD patients, although AD patients performed less well on the WMS and the RBMT. Some interesting findings regarding semantic memory, face recognition, and metamemory in AD patients are also reported. Age, education, but no gender effects on memory performance were also detected.


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