Intake of Lactiplantibacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress: A randomized, double blind, placebo-controlled study

Acute psychological stress is positively associated with a cold/flu. The present randomised, double-blind, placebo-controlled study examined the effect of three potentially probiotic bacteria on the proportion of healthy days over a 6-week period in academically stressed undergraduate students (n 581) who received Lactobacillus helveticus R0052, Bifidobacterium longum ssp. infantis R0033, Bifidobacterium bifidum R0071 or placebo. On each day, participants recorded the intensity (scale: 0 = not experiencing to 3 = very intense) for nine cold/flu symptoms, and a sum of symptom intensity >6 was designated as a day of cold/flu. B. bifidum resulted in a greater proportion of healthy days than placebo (P≤ 0·05). The percentage of participants reporting ≥ 1 d of cold/flu during the 6-week intervention period was significantly lower with B. bifidum than with placebo (P< 0·05). There were no effects of B. infantis or L. helveticus compared with placebo on either outcome. A predictive model accounted for influential characteristics and their interactions on daily reporting of cold/flu episodes. The proportion of participants reporting a cold on any given day was lower at weeks 2 and 3 with B. bifidum and B. infantis than with placebo for the average level of stress and the most commonly reported number of hours of sleep. Daily intake of bifidobacteria provides benefit related to cold/flu outcomes during acute stress.

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Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: A randomized, double-blind, placebo-controlled study

Brain Behavior and Immunity ◽

10.1016/j.bbi.2007.07.005 ◽

2008 ◽

Vol 22 (2) ◽

pp. 150-157 ◽

Cited By ~ 16

Author(s):

Roland von Känel ◽

Brigitte M. Kudielka ◽

Petra Metzenthin ◽

Susanne Helfricht ◽

Daniel Preckel ◽

...

Keyword(s):

Interleukin 6 ◽

Acute Stress ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Circulating Levels

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Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: A randomized, double-blind, placebo-controlled study

Scandinavian Journal of Infectious Diseases ◽

10.1080/00365540903168056 ◽

2009 ◽

Vol 41 (10) ◽

pp. 760-766 ◽

Cited By ~ 30

Author(s):

Marianne Thusgaard ◽

Jesper H. Christensen ◽

Birgitte Mørn ◽

Tina S. Andersen ◽

Runar Vige ◽

...

Keyword(s):

Fatty Acids ◽

Antiretroviral Therapy ◽

Polyunsaturated Fatty Acids ◽

Fish Oil ◽

Inflammatory Markers ◽

Plasma Lipids ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo

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Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial

Nutrition Journal ◽

10.1186/s12937-021-00748-8 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Ryusei Uchio ◽

Kengo Kawasaki ◽

Chinatsu Okuda-Hanafusa ◽

Ryosuke Saji ◽

Koutarou Muroyama ◽

...

Keyword(s):

Mental Health ◽

Placebo Group ◽

Inflammatory Markers ◽

Curcuma Longa ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Sf 36 ◽

Anti Inflammatory ◽

Serum Inflammatory Markers

Abstract Background The dietary spice Curcuma longa, also known as turmeric, has various biological effects. Both a water extract and a supercritical carbon dioxide extract of C. longa showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two C. longa extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health. Methods We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a t test (significance level, p < 0.05). Results After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score (p < 0.05). Conclusion CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance. Trial registration UMIN-CTR, UMIN000037370. Registered 14 July 2019, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000042607

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