β-Resorcylic acid derivatives with α-glucosidase inhibitory activity from Lasiodiplodia sp. ZJ-HQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius

Four new α-pyrones, hypotiens A–D (1–4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera.

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Isolation of Endophytic Fungi QPS 05 from Quercus phillyraeoides A. Gray and Its Potential for α-Glucosidase Inhibitory Activity

Jurnal Kimia Terapan Indonesia ◽

10.14203/jkti.v20i1.372 ◽

2018 ◽

Vol 20 (1) ◽

pp. 1-7

Author(s):

Anastasia Wheni Indrianingsih ◽

Amalia Indah Prihantini ◽

Sanro Tachibana

Keyword(s):

Fatty Acids ◽

Endophytic Fungi ◽

Inhibitory Activity ◽

Endophytic Fungus ◽

Inhibitory Concentration ◽

Life Cycles ◽

Ic50 Values ◽

Quercus Phillyraeoides ◽

Alternaria Sp ◽

Harmful Effects

AbstractEndophytic fungi are the microorganisms that spend all or part of their life cycles within plant tissue without causing harmful effects on the plant. In this study, 14 endophytic fungus from Quercus phillyraeoides A. Gray were isolated. Alternaria sp. QPS 05, an endophytic fungi which was isolated from the stem of Q. phillyraeoides A. Gray showed the highest α-glucosidase inhibitory activity. Further separation of ethyl acetate extract from the fungus led to the isolation of active substance from hexane-soluble fraction which give fatty acids mixture consist of palmitic acid, oleic acid, linoleic acid and linolenic acid (1) strong inhibitory activity against α-glucosidase. Isolated fatty acids (1) had inhibitory concentration (IC50) values against Saccharomyces cerevisiae was 12.10 μg/mL. The results of the present study showed that endophytic fungus from Alternaria sp. QPS 05 potentially contained a rich source of natural antidiabetic medicine.

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Bioactive Metabolites Produced by the Endophytic Fungus Phomopsis sp. YM355364

Natural Product Communications ◽

10.1177/1934578x1400900521 ◽

2014 ◽

Vol 9 (5) ◽

pp. 1934578X1400900 ◽

Cited By ~ 1

Author(s):

Kai-Xia Ma ◽

Xin-Tian Shen ◽

Rong Huang ◽

Tang Wang ◽

Xiao-Song Xie ◽

...

Keyword(s):

Spectral Analysis ◽

Inhibitory Activity ◽

Endophytic Fungus ◽

Influenza A ◽

Pathogenic Fungi ◽

Bioactive Metabolites ◽

Antifungal Activities ◽

Aconitum Carmichaeli

A new compound, 16-acetoxycytosporone B (1), along with four known ones, dankasterone A (2), dankasterone B (3), 3β,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (4), and cyclonerodiol oxide (5), were isolated from Phomopsis sp. YM355364, an endophytic fungus of Aconitum carmichaeli. Their structures were characterized by spectral analysis. Compound 2 exhibited significant inhibitory activity against influenza A/Thailand/Kan353/2004(H5N1) pseudovirus with an IC50 value of 3.56 μM. Compounds 1, 2, and 4 showed either moderate or weak antifungal activities against four pathogenic fungi.

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Rhizovagine A, an unusual dibenzo-α-pyrone alkaloid from the endophytic fungus Rhizopycnis vagum Nitaf22

RSC Advances ◽

10.1039/d0ra05022a ◽

2020 ◽

Vol 10 (47) ◽

pp. 27894-27898 ◽

Cited By ~ 3

Author(s):

Ali Wang ◽

Siji Zhao ◽

Gan Gu ◽

Dan Xu ◽

Xuping Zhang ◽

...

Keyword(s):

Inhibitory Activity ◽

Endophytic Fungus ◽

Acetylcholinesterase Inhibitory Activity

Rhizovagine A (1), a dibenzo-α-pyrone alkaloid with a 5/5/6/6/6 fused pentacyclic skeleton and acetylcholinesterase inhibitory activity, was isolated from the endophytic fungus Rhizopycnis vagum Nitaf22.

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