Evidence of oxidative stress-induced and gestational age-dependent senescence in pathological and post-mature human placentas

Glaucoma is an age-dependent disease closely related to oxidative stress and is regarded as the second leading cause of irreversible blindness worldwide. In recent years, many studies have shown that morphological and functional abnormalities of the trabecular meshwork (TM) are closely related to glaucoma, especially with respect to oxidative stress. In this review, the mechanisms of oxidative stress in the TM and treatment strategies for this condition, including strategies involving antioxidants, noncoding RNAs and exogenous compounds, are discussed. Although many questions remain to be answered, the reviewed findings provide insights for further research on oxidative stress alleviation in glaucoma and suggest new targets for glaucoma prevention.

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The Cyclic Feeding Regime Induces Decaying Age-Dependent Oxidative Stress and Regulates the Cell Chain of the Immunity

Advances in Aging Research ◽

10.4236/aar.2016.56015 ◽

2016 ◽

Vol 05 (06) ◽

pp. 151-165

Author(s):

Anatoly I. Bozhkov ◽

Yuriy V. Nikitchenko ◽

Katerina N. Lebed’ ◽

Olena S. Linkevych ◽

Natalia I. Kurguzova ◽

...

Keyword(s):

Oxidative Stress ◽

Feeding Regime ◽

Age Dependent ◽

Cyclic Feeding

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Cord Malaria Infection, Complement Activation, Oxidative Stress, Gestational Age, and Birth Weight, Characterized by High Plasmodium falciparum Prevalence in Bamenda, Cameroon

Journal of Tropical Medicine ◽

10.1155/2020/7209542 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Oumar Mahamat ◽

Kidio Gisele Ndum ◽

Sumo Laurentine ◽

Ntonifor Ngum Helen

Keyword(s):

Oxidative Stress ◽

Birth Weight ◽

Cord Blood ◽

Umbilical Cord ◽

Negative Correlation ◽

Gestational Age ◽

Blood Samples ◽

Total Antioxidant ◽

Weak Negative Correlation ◽

And Oxidative Stress

Background. It is unknown whether the presence of Plasmodium falciparum malaria parasites in umbilical cord blood denotes activation of complement and oxidative stress to affect the duration of pregnancy and birth weight. Methods. In a cross-sectional study conducted from January to April 2019 in Bamenda, Cameroon, cord blood samples were collected from 300 women at delivery. Parasitaemia was determined microscopically. Babies’ weight and age of gestation were recorded. Plasma levels of complement and oxidative stress were measured by specific tests. Results. Cord blood malaria prevalence was 21.33%. Babies with an infected cord showed a low birth weight and gestation age than those with uninfected cords. More babies with infected cords had LBW (6.25%) compared to the counterparts (5.50%). The levels of parasitaemia and the babies’ weight showed a weak positive correlation. The prevalence of preterm and postterm birth was 4.33% and 24.33% respectively, with a weak negative correlation between the age of gestation and the umbilical cord parasitaemia. There was correlation between cord parasitaemia and levels of complement haemolytic activity titter (CH50) and specific classical pathway activity (CPA) in cord blood. CH50 and CPA levels, however, were significantly higher in infected cord blood samples, compared with uninfected cord blood samples. CH50 showed a negative correlation with the birth weight and gestational age in infected cord blood samples. The levels of total oxidative stress (TOS) and total antioxidant defense were significantly lower in infected cord blood than uninfected. TOS displayed a positive correlation with the density of parasitaemia and a weak negative correlation with the birth weight and gestational age in infected cord blood. Conclusion. Cord blood infection lowers the complement haemolytic titter, oxygen radicals and total antioxidant defense in neonates. This lowering of complement haemolytic titter and oxygen radical compounds in umbilical cord malaria are associated with low birth weight and preterm birth.

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Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance

Biomedical Research ◽

10.2220/biomedres.33.319 ◽

2012 ◽

Vol 33 (5) ◽

pp. 319-322 ◽

Cited By ~ 2

Author(s):

Yasunari Kayashima ◽

Kimiko Yamakawa-Kobayashi

Keyword(s):

Oxidative Stress ◽

Stress Resistance ◽

Oxidative Stress Resistance ◽

Age Dependent

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Reactivity of isolated human chorionic vessels: analysis of some influencing variables

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y03-119 ◽

2003 ◽

Vol 81 (12) ◽

pp. 1147-1151 ◽

Cited By ~ 6

Author(s):

Antonio Abad ◽

Luis Estañ ◽

Francisco J Morales-Olivas ◽

Vicente Serra

Keyword(s):

Cold Storage ◽

Gestational Age ◽

Vascular Reactivity ◽

Elective Caesarean Section ◽

Mode Of Delivery ◽

Vascular Rings ◽

Normal Term ◽

Age Dependent ◽

Concentration Response Curve

The aim of the study was to determine whether 24 h of cold storage of samples, mode of delivery, and gestational age influenced in vitro human chorionic vascular reactivity (35 arteries and 34 veins). The following groups were compared: (i) fresh versus 24-h cold-stored (4 °C in Krebs–Henseleit solution) chorionic vascular rings from normal term placentas, (ii) fresh chorionic vascular rings from normal term placentas obtained after vaginal delivery versus those obtained after elective caesarean section, and (iii) fresh chorionic vascular rings from normal term placentas versus those obtained from preterm deliveries. Isometric recording of the concentration–response curve to KCl (5–120 mM) was assesed in each group. In vitro human chorionic vascular reactivity was influenced negatively by the 24-h cold storage of samples, with only 30% of stored samples being weakly reactive to KCl. Human chorionic vascular reactivity to KCl was unaffected by the mode of delivery. However, the response to KCl was gestational-age dependent. Thus, preterm vascular rings exhibited a significantly (P < 0.05) decreased response (Emax = 9.8 ± 0.0 mN; EC50 = 26.0 ± 1.3 mM) compared with term samples (Emax = 21.6 ± 2 mN; EC50 = 13.9 ± 1.6 mM). In conclusion, this study provides evidence that fresh term vascular rings are the tissues of choice for studying human chorionic vascular reactivity.Key words: human chorionic vessels, placenta, vascular reactivity.

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