Risperidone and liver function tests in children and adolescents: A short-term prospective study

ObjectiveRisperidone is an atypical antipsychotic agent, despite its many advantages and widespread use, there is increasing attention to the adverse effects associated with long-term exposure to this drug.We aimed to investigate the changes in the liver function tests (LFTs) associated with one year risperidone treatment in children and adolescents.MethodsOne hundred youths who treated with risperidone more than one year were included in the study. For this study, patients’ baseline and follow-up weight and hepatobiliary function tests including alanine aminotransferases(ALT) and aspartat aminotransferases (AST), gamma gluatamyl transerase (GGT), alkaline phosphatase (ALP) and serum bilirubin levels were measured baseline, after the treatment period of six months and one year.ResultsAsymptomatic liver function test abnormalities mostly ALP elevation was found in subjects treated with risperidone. The mean levels of liver enzymes and billuribin of the patients were significantly higher after one year of treatment than the baseline. Also the mean levels of liver enzymes and billuribin of the patients were significantly higher after one year of treatment than the six months. There was significant association between changes in weight, risperidone dose and liver enzymes and billuribin levels.ConclusionsThese findings suggest that risperidone treatment in the long term commonly leads to liver function changes however it rarely may induce a serious hepatic toxicity at therapeutic doses in children and adolescents.

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Correlation between postoperative liver function tests and short term (<1 year) mortality following living donor liver transplantation

Journal of Clinical and Experimental Hepatology ◽

10.1016/j.jceh.2013.03.190 ◽

2013 ◽

Vol 3 (1) ◽

pp. S110-S111

Author(s):

H.S. Preetham ◽

K.H. Ismail Siyad ◽

Harikumar R. Nair ◽

V.A. Narayanan ◽

S. Sudhindran

Keyword(s):

Liver Transplantation ◽

Liver Function ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Liver Function Tests ◽

Donor Liver ◽

Short Term ◽

Donor Liver Transplantation ◽

Function Tests

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Antioxidant Supplements Reduced Oxidative Stress and Stabilized Liver Function Tests but Did Not Reduce Inflammation in a Randomized Controlled Trial in Obese Children and Adolescents

Journal of Nutrition ◽

10.3945/jn.113.185561 ◽

2013 ◽

Vol 144 (2) ◽

pp. 193-201 ◽

Cited By ~ 35

Author(s):

Stefanie B. Murer ◽

Isabelle Aeberli ◽

Christian P. Braegger ◽

Matthias Gittermann ◽

Martin Hersberger ◽

...

Keyword(s):

Oxidative Stress ◽

Randomized Controlled Trial ◽

Liver Function ◽

Children And Adolescents ◽

Controlled Trial ◽

Liver Function Tests ◽

Obese Children ◽

Randomized Controlled ◽

Function Tests ◽

Antioxidant Supplements

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Aminotransferase Levels in Relation to Short-Term use of Acetaminophen Four Grams Daily in Postoperative Cardiothoracic Patients in the Intensive Care Unit

Anaesthesia and Intensive Care ◽

10.1177/0310057x1103900612 ◽

2011 ◽

Vol 39 (6) ◽

pp. 1056-1063 ◽

Cited By ~ 7

Author(s):

S. J. G. M. Ahlers ◽

L. van Gulik ◽

E. P. A. van Dongen ◽

P. Bruins ◽

D. Tibboel ◽

...

Keyword(s):

Intensive Care Unit ◽

Cardiac Surgery ◽

Intensive Care ◽

Liver Function ◽

Alanine Aminotransferase ◽

Liver Function Tests ◽

Analgesic Agent ◽

Short Term ◽

Function Tests ◽

Volunteer Study

A volunteer study suggested that taking paracetamol 4 g daily could result in elevated alanine aminotransferase plasma levels in a substantial proportion of healthy volunteers. The safety of this dose of paracetamol for acute postoperative pain remains controversial. This study aimed to examine the incidence of alanine aminotransferase elevations after short-term use of paracetamol 4 g daily, as part of the standard pain management protocol, for 93 consecutive patients after cardiothoracic surgery. Alanine aminotransferase levels and other liver function tests were measured preoperatively as baseline and once daily after surgery during the intensive care unit stay. Preoperative alanine aminotransferase levels of more than one time the upper limit of normal (ULN, >40 U/l) was observed in 11% (n=10) of the patients but none of these baseline alanine aminotransferase levels exceeded three times the ULN (>3×ULN). The average daily dose of paracetamol administered was 50 mg/kg (SD=16) after surgery. Postoperative alanine aminotransferase levels of >1×ULN was observed in 17% (n=16), and 4% (n=4) exceeded >3×ULN. The other liver function tests of the latter four patients, including aspartate aminotransferase (range 173 to 5590 U/l), γ-glutamyltransferase (range 56 to 103 U/l), lactate dehydrogenase (range 376 to 3518 U/l) and the International Normalised Ratio (range 2.0 to 6.6), were all abnormal. These four patients all had right ventricular failure or cardiogenic shock during the postoperative period which could explain the significant rises in alanine aminotransferase after surgery. In conclusion, the incidence of significant alanine aminotransferase elevations after using daily paracetamol as an analgesic agent for cardiac surgery, at a dose of 4 g per day, was low and mostly due to complications after surgery. Our results, albeit still very limited, provided some reassurance about the safety of paracetamol 4 g daily, as a supplementary analgesic agent for adult patients undergoing cardiac surgery.

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