Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression

2009 ◽  
Vol 33 (8) ◽  
pp. 1417-1424 ◽  
Author(s):  
Haixia Dang ◽  
Ying Chen ◽  
Xinmin Liu ◽  
Qiong Wang ◽  
Liwei Wang ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Chronic Mild Stress ◽  
Forced Swimming ◽  
Mild Stress ◽  
Antidepressant Effects ◽  
Swimming Test ◽  
Stress Models

scholarly journals Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERK/ERK and p-P38/P38

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jian Xu ◽  
Yanling She ◽  
Ning Su ◽  
Ruixin Zhang ◽  
Lixing Lao ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Sucrose Solution ◽  
Chronic Mild Stress ◽  
Forced Swimming ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Sprague Dawley ◽  
Unpredictable Chronic Mild Stress ◽  
Immobility Time ◽  
Swimming Test

We investigate the antidepressant-like effect and mechanism of electroacupuncture (EA) on a chronic unpredictable mild stress rats depression-like behavior. In our study, depression in rats was induced by unpredictable chronic mild stress (UCMS) and isolation for four weeks. Male Sprague-Dawley rats were randomly divided into four groups: Normal, Model, EA, and Sham EA. EA treatment was administered for two weeks, once a day for five days a week. Two acupoints, Yintang (EX-HN3) and Baihui (GV20), were selected. For sham EA, acupuncture needles were inserted shallowly into the acupoints: EX-HN3 and GV20. No electrostimulator was connected. The antidepressant-like effect of the electroacupuncture treatment was measured by sucrose intake test, open field test, and forced swimming test in rats. The protein levels of phosphorylated extracellular regulated protein kinases (p-ERK1/2)/ERK1/2 and p-P38/P38 in the hippocampus (HP) were examined by Western blot analysis. Our data demonstrate that EA treatment decreased the immobility time of forced swimming test and improved the sucrose solution intake in comparison to unpredictable chronic mild stress and placebo sham control. Electroacupuncture may act on depression by enhancing p-ERK1/2 and p-p38 in the hippocampus.

scholarly journals Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.

2001 ◽  
Vol 24 (7) ◽  
pp. 848-851 ◽  
Author(s):  
Veronika BUTTERWECK ◽  
Sansei NISHIBE ◽  
Tsutomu SASAKI ◽  
Masaru UCHIDA
Keyword(s):  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Apocynum Venetum ◽  
Swimming Test

scholarly journals Using tests and models to assess antidepressant-like activity in rodents

2016 ◽  
Vol 29 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Ewa Kedzierska ◽  
Izabela Wach
Keyword(s):  
Animal Models ◽  
Learned Helplessness ◽  
Forced Swimming Test ◽  
Chronic Mild Stress ◽  
Tail Suspension Test ◽  
Depression Treatment ◽  
Mild Stress ◽  
Animal Models Of Depression ◽  
Important Challenge ◽  
Swimming Test

Abstract In today's world, depression is one of the more prevalent forms of mental illness. According to WHO, about 10%-30% of all women and 7%-15% of all men are afflicted by depression at least once in their life-times. Today, depression is assessed to be affecting 350 million people. Regarding this issue, an important challenge for current psychopharmacology is to develop new, more effective pharmacotherapy and to understand the mechanism of action of known antidepressants. Furthermore, there is the necessity to improve the effectiveness of anti-depression treatment by way of bringing about an understanding of the neurobiology of this illness. In achieving these objectives, animal models of depression can be useful. Yet, presently, all available animal models of depression rely on two principles: the actions of known antidepressants or the responses to stress. In this paper, we present an overview of the most widely used animal tests and models that are employed in assessing antidepressant-like activity in rodents. These include amphetamine potentiation, reversal of reserpine action, the forced swimming test, the tail suspension test, learned helplessness, chronic mild stress and social defeat stress. Moreover, the advantages and major drawbacks of each model are also discussed.

scholarly journals Evaluation of antidepressant-like effect Lavandulifolia stachys in the forced swimming test in comparison with imipramine and fluoxetine

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Shirali Kharamin ◽  
Saeed Razmeh ◽  
Mona Nabovvati ◽  
Karim Moradian ◽  
Samaneh Rahimi ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Drug ◽  
Behavioral Responses ◽  
Forced Swimming ◽  
Saline Control ◽  
Control Group ◽  
Health Issues ◽  
Treatment Of Depression ◽  
Antidepressant Effects ◽  
Swimming Test

Depression is a global problem associated with multiple social and health issues. In the present study, we analyzed the antidepressant effects of Lavandulifolia stachys, an herbal planton forced swimming test (FST). In this study, 36 rats were used. We gavaged the aqueous extract of plant (50, 100, 150 mg/kg), imipramine and fluoxetine (20 mg/kg) as standard antidepressant drug and normal saline for control group for a week. Then, their behavioral responses including climbing, swimming and immobility were recorded during the 5-min FST. Our experiments showed significant effects of Lavandulifolia stachys on swimming and immobility but not effect on climbing behaviors. Imipramine and fluoxetine increased climbing and swimming, respectively, and both reduced immobility, compared to saline control. Finally, our results show the extract of Lavandulifolia stachys could play an important role in treatment of depression like fluoxetine.

The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors

2008 ◽  
Vol 578 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Rui Wang ◽  
Ying Xu ◽  
Hong-Li Wu ◽  
Ying-Bo Li ◽  
Yu-Hua Li ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Swimming Test

Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala

2011 ◽  
Vol 23 (5) ◽  
pp. 241-248 ◽  
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Karine F. Ribeiro ◽  
Tatiana Luft ◽  
Helena M. Abelaira ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Forced Swimming Test ◽  
Cannabis Sativa ◽  
Field Tests ◽  
Brain Derived Neurotrophic Factor ◽  
Chemical Constituent ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Immobility Time ◽  
Swimming Test

Réus GZ, Stringari RB, Ribeiro KF, Luft T, Abelaira HM, Fries GR, Aguiar BW, Kapczinski F, Hallak JE, Zuardi AW, Crippa JA, Quevedo J. Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala.Objective: Cannabidiol is a chemical constituent from Cannabis sativa and it has multiple mechanisms of action, including antidepressant effects. The main objective of the present study was to evaluate behavioural and molecular effects induced by administration of cannabidiol and imipramine in rats.Methods: In the present study, rats were acutely or chronically treated for 14 days once a day with saline, cannabidiol (15, 30 and 60 mg/kg) or imipramine (30 mg/kg) and the animals behaviour was assessed in forced swimming and open-field tests. Afterwards, the prefrontal cortex, hippocampus and amygdala brain-derived neurotrophic factor (BDNF) levels were assessed by enzyme-linked immunosorbent sandwich assay.Results: We observed that both acute and chronic treatments with imipramine at the dose of 30 mg/kg and cannabidiol at the dose of 30 mg/kg reduced immobility time and increased swimming time; climbing time was increased only with imipramine at the dose of 30 mg/kg, without affecting locomotor activity. In addition, chronic treatment with cannabidiol at the dose of 15 mg/kg and imipramine at the dose of 30 mg/kg increased BDNF levels in the rat amygdala.Conclusion: In conclusion, our results indicate that cannabidiol has an antidepressant-like profile and could be a new pharmacological target for the treatment of major depression.

Experimental anxiety-depressive state in rats caused by neonatal exposure to the inhibitor of dipeptidyl peptidase IV, diprotin A: effects of imipramine

2017 ◽  
pp. 4-12
Author(s):  
Н.Н. Хлебникова ◽  
Н.А. Крупина
Keyword(s):  
Forced Swimming Test ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Forced Swimming ◽  
Face Validity ◽  
Neonatal Exposure ◽  
Depressive State ◽  
Serum Corticosterone ◽  
Old Rats ◽  
Swimming Test

В наших предыдущих исследованиях было показано, что ингибитор пролинспецифической пептидазы дипептидилпептидазы-IV (ДП-IV, EC 3.4.14.5) трипептид дипротин А, введенный крысам в 5-18 постнатальные дни, приводит к развитию у крыс подросткового возраста и взрослых животных эмоционально-мотивационных расстройств. Такие расстройства можно рассматривать как модель смешанного тревожно-депрессивного состояния. Однако специальных исследований по валидности данной модели проведено не было. Цель настоящей работы состояла в проверке влияния трициклического антидепрессанта имипрамина (ИМИ) на депрессивноподобное поведение крыс и уровень кортикостерона в сыворотке крови животных на модели смешанного тревожно-депрессивного состояния. Методика. У крыс в возрасте одного и двух мес. определяли уровень тревожности в автоматизированном тесте «Приподнятый крестообразный лабиринт» и оценивали депрессивноподобное поведение в тесте принудительного плавания. ИМИ вводили взрослым животным в течение 10 дней (20 мг/кг/день, интрагастрально). Уровень кортикостерона в сыворотке крови определяли методом твердофазного иммуноферментного анализа. Результаты. Неонатальное действие дипротина А приводило к повышению тревожности у крыс в возрасте 1 мес. Депрессивноподобное поведение обнаружено у животных в возрасте одного и двух мес. ИМИ нормализовал поведение животных в тесте принудительного плавания и снижал уровень кортикостерона в сыворотке крови крыс. Кроме того, ИМИ снижал вес крыс. Заключение. Результаты исследования свидетельствуют в пользу адекватности модели смешанного тревожно-депрессивного расстройства, возникающего у крыс вследствие действия ингибитора ДП-IV дипротина А на второй-третьей неделях постнатального развития, клиническому прообразу заболевания по критериям «внешней схожести», прогностической и конструкционной валидности. Previously, we have shown that the inhibitor of proline-specific peptidase, dipeptidyl peptidase-IV (DP-IV, EC 3.4.14.5), tripeptide diproptin A administered on postnatal days 5-18 induced emotional and motivational disorders in adolescent and adult rats. These disorders can be considered a model of a mixed anxiety-depression-like disorder. However, validation studies of this model are not available. The aim of this work was to test the effect of the tricyclic antidepressant, imipramine (IMI), on depressive-like behavior in rats and the level of serum corticosterone using the model of mixed anxiety-depressive state. Methods. The level of anxiety was assessed by the automated Elevated Plus Maze test and the depressive-like behavior was evaluated by the forced swimming test in one- and two-month old rats. IMI was administered to adult animals for ten days (20 mg/kg a day, intragastrically). Serum corticosterone concentrations were measured using ELISA. Results. The neonatal exposure to diprotin A increased anxiety in one-month old rats. The depressive-like behavior was observed in animals aged one and two months. IMI normalized behavior of animals in the forced swimming test and reduced serum levels of corticosterone. Also, IMI reduced body weight of rats. Conclusion. The results of the study evidenced adequacy of the model of mixed anxiety-depressive state induced by the DP-IV inhibitor, diprotin A, on the second and third postnatal weeks to the clinical prototype of disease according to criteria of face validity, predictive and construct validity.

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