Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala

2011 ◽  
Vol 23 (5) ◽  
pp. 241-248 ◽  
Author(s):  
Gislaine Z. Réus ◽  
Roberto B. Stringari ◽  
Karine F. Ribeiro ◽  
Tatiana Luft ◽  
Helena M. Abelaira ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Forced Swimming Test ◽  
Cannabis Sativa ◽  
Field Tests ◽  
Brain Derived Neurotrophic Factor ◽  
Chemical Constituent ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Immobility Time ◽  
Swimming Test

Réus GZ, Stringari RB, Ribeiro KF, Luft T, Abelaira HM, Fries GR, Aguiar BW, Kapczinski F, Hallak JE, Zuardi AW, Crippa JA, Quevedo J. Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala.Objective: Cannabidiol is a chemical constituent from Cannabis sativa and it has multiple mechanisms of action, including antidepressant effects. The main objective of the present study was to evaluate behavioural and molecular effects induced by administration of cannabidiol and imipramine in rats.Methods: In the present study, rats were acutely or chronically treated for 14 days once a day with saline, cannabidiol (15, 30 and 60 mg/kg) or imipramine (30 mg/kg) and the animals behaviour was assessed in forced swimming and open-field tests. Afterwards, the prefrontal cortex, hippocampus and amygdala brain-derived neurotrophic factor (BDNF) levels were assessed by enzyme-linked immunosorbent sandwich assay.Results: We observed that both acute and chronic treatments with imipramine at the dose of 30 mg/kg and cannabidiol at the dose of 30 mg/kg reduced immobility time and increased swimming time; climbing time was increased only with imipramine at the dose of 30 mg/kg, without affecting locomotor activity. In addition, chronic treatment with cannabidiol at the dose of 15 mg/kg and imipramine at the dose of 30 mg/kg increased BDNF levels in the rat amygdala.Conclusion: In conclusion, our results indicate that cannabidiol has an antidepressant-like profile and could be a new pharmacological target for the treatment of major depression.

Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Azadeh Mesripour ◽  
Shahrzad Shahnooshi ◽  
Valiollah Hajhashemi
Keyword(s):  
Side Effects ◽  
Forced Swimming Test ◽  
Interferon Alfa ◽  
Interferon Α ◽  
High Dose ◽  
Antidepressant Effects ◽  
Immobility Time ◽  
Inflammatory Drugs ◽  
Swimming Test ◽  
Psychiatric Side Effects

AbstractBackgroundInterferon-α (IFNα) therapy causes psychiatric side effects, including depression that may result in poor compliance of therapy. It is important to find alternative therapies for the prevention of IFNα induced depression. Non-steroidal anti-inflammatory drugs (NSAIDs) have been useful in depressive disorder. Therefore the effects of celecoxib, ibuprofen, and indomethacin were evaluated following IFNα-induced depression in mice.MethodsMale albino mice weighing 26 ± 2 g were used. Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days. Animals were first subject to the locomotor test, then the splash test and finally the forced swimming test (FST) on the 7th day. The NSAIDs were administered (IP) either one single dose before the test, or simultaneously with IFNα.Resultslocomotor activity was only impaired by ibuprofen high dose (75 mg/kg), thus it was not further evaluated. Following IFNα therapy depression-like behaviors were observed; significant changes during the splash test (grooming time 24 ± 7 sec vs. control 63 ± 7 sec), the FST (immobility time 166  ± 15 sec vs. control 128  ± 6 sec), and sucrose preference reduced to 64 ± 0.8%. The NSAIDs noticeably reduced the immobility time in FST, while grooming time was increased. Celecoxib and indomethacin single doses were effective while ibuprofen showed better antidepressant effects when it was administered along with IFNα.ConclusionsThe NSAIDs were able to prevent IFNα induced depression in mice. NSAIDs administration with IFNα does not interfere with clinical benefit effects of IFNα and they could also be useful to prevent IFNα psychiatric side effects, thus further clinical trials are suggested.

scholarly journals Antidepressant Effects of Apocynum venetum Leaves in a Forced Swimming Test.

2001 ◽  
Vol 24 (7) ◽  
pp. 848-851 ◽  
Author(s):  
Veronika BUTTERWECK ◽  
Sansei NISHIBE ◽  
Tsutomu SASAKI ◽  
Masaru UCHIDA
Keyword(s):  
Forced Swimming Test ◽  
Forced Swimming ◽  
Antidepressant Effects ◽  
Apocynum Venetum ◽  
Swimming Test

Clinical doses of citalopram or reboxetine differentially modulate passive and active behaviors of female Wistar rats with high or low immobility time in the forced swimming test

2013 ◽  
Vol 110 ◽  
pp. 89-97 ◽  
Author(s):  
Ana Gisela Flores-Serrano ◽  
María Leonor Vila-Luna ◽  
Fernando José Álvarez-Cervera ◽  
Francisco José Heredia-López ◽  
José Luis Góngora-Alfaro ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Immobility Time ◽  
Female Wistar Rats ◽  
Swimming Test

scholarly journals Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent

2021 ◽  
Vol 10 (11) ◽  
pp. e191101119571
Author(s):  
Amanda Fonseca Costa Assunção ◽  
Nícolas Davidson Sérvulo Rodrigues ◽  
Andreia Viana da Costa Sampaio ◽  
Karolinny dos Santos Silva ◽  
Laryssa Roque da Silva ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Forced Swimming Test ◽  
Open Field Test ◽  
Tail Suspension Test ◽  
Experimental Tests ◽  
Forced Swimming ◽  
Tail Suspension ◽  
Immobility Time ◽  
Swimming Test ◽  
Antidepressant Action

Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing the total immobility time presented by the animals of the experimental groups in the test session, using the Forced Swimming Test and the Tail Suspension Test. The parameters of locomotion (central, peripheral and total) and motor coordination were evaluated in the Open Field Test and in the Rota Rod Test, respectively. In the second stage, the involvement of the noradrenergic system in the antidepressant action of alpha-terpineol in Forced Swimming Test was investigated. Results and Discussion: After performing the experimental tests, it was observed that the animals that received alpha-terpineol had reduced immobility time in Forced Swimming Test and Tail Suspension Test, compared to the other groups. In the Open Field Test and Rota-rod, the mice showed, respectively, good exploratory activity and motor coordination during the tests. In addition, the study of the Noradrenergic System proved to be a promising mechanism used during its antidepressant action. Conclusion: In view of the results of the experimental tests, alpha-terpineol presented similar responses to those found in other monoterpenes investigated in the literature. Thus, it is shown as a promising antidepressant to be used clinically in humans, with less side effects and low production cost.

scholarly journals Effects of Electroacupuncture on Chronic Unpredictable Mild Stress Rats Depression-Like Behavior and Expression of p-ERK/ERK and p-P38/P38

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jian Xu ◽  
Yanling She ◽  
Ning Su ◽  
Ruixin Zhang ◽  
Lixing Lao ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Sucrose Solution ◽  
Chronic Mild Stress ◽  
Forced Swimming ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Sprague Dawley ◽  
Unpredictable Chronic Mild Stress ◽  
Immobility Time ◽  
Swimming Test

We investigate the antidepressant-like effect and mechanism of electroacupuncture (EA) on a chronic unpredictable mild stress rats depression-like behavior. In our study, depression in rats was induced by unpredictable chronic mild stress (UCMS) and isolation for four weeks. Male Sprague-Dawley rats were randomly divided into four groups: Normal, Model, EA, and Sham EA. EA treatment was administered for two weeks, once a day for five days a week. Two acupoints, Yintang (EX-HN3) and Baihui (GV20), were selected. For sham EA, acupuncture needles were inserted shallowly into the acupoints: EX-HN3 and GV20. No electrostimulator was connected. The antidepressant-like effect of the electroacupuncture treatment was measured by sucrose intake test, open field test, and forced swimming test in rats. The protein levels of phosphorylated extracellular regulated protein kinases (p-ERK1/2)/ERK1/2 and p-P38/P38 in the hippocampus (HP) were examined by Western blot analysis. Our data demonstrate that EA treatment decreased the immobility time of forced swimming test and improved the sucrose solution intake in comparison to unpredictable chronic mild stress and placebo sham control. Electroacupuncture may act on depression by enhancing p-ERK1/2 and p-p38 in the hippocampus.

scholarly journals Effects of Stimulation and Blockade of Receptor on Depression-Like Behavior in Ovariectomized Female Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Julia Fedotova
Keyword(s):  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Low Dose ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Female Rats ◽  
Ovx Rats ◽  
Wistar Strain ◽  
Immobility Time ◽  
Swimming Test

The aim of the present study was to explore the hedonic effects of D2 receptor agonist, quinpirole and D2 receptor antagonist, and sulpiride alone or in combination with a low dose of 17β-E2-estradiol (17β-E2) in the adult ovariectomized female rats (OVX). OVX rats of Wistar strain were used in all experiments. Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17β-E2 (5.0 μg/rat), quinpirole (0.1 mg/kg), sulpiride (10.0 mg/kg), quinpirole plus 17β-E2, or sulpiride plus 17β-E2 for 14 days before the forced swimming test. We found that sulpiride significantly decreased immobility time in the OVX females. A combination of sulpiride with a low dose of 17β-E2 induced more profound decrease of immobility time in the OVX rats compared to the rats treated with sulpiride alone. On the contrary, quinpirole failed to modify depression-like behavior in the OVX rats. In addition, quinpirole significantly blocked the antidepressant-like effect of 17β-E2 in OVX rats. Thus, the D2 receptor antagonist sulpiride alone or in combination with a low dose of 17β-E2 exerted antidepressant-like effect in OVX female rats, while the D2 receptor agonist quinpirole produced depressant-like profile on OVX rats.

Lack of effect of eicosapentaenoic acid in the Porsolt forced swimming test model of depression

2002 ◽  
Vol 14 (5) ◽  
pp. 203-206 ◽  
Author(s):  
Alona Shaldubina ◽  
Boris Nemets ◽  
Yuly Bersudsky
Keyword(s):  
Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Test Model ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Immobility Time ◽  
Swimming Test ◽  
Clinical Experiments

Background:Eicosapentaenoic acid (EPA) is one of the major components of fish oils. Omega-3 fatty acids, particularly EPA, have been hypothesized to play a role in the etiology, pathogenesis and treatment of mood disorders. Clinical studies have shown beneficial effects of omega-3 fatty acids in major depression, bipolar disorder and other psychiatric disorders.Objective:The present study design evaluates the effect of EPA in the Porsolt forced swimming test.Results:EPA alone did not reduce the immobility time and did not enhance the anti-immobility effect of a low dose of imipramine. Contrary to the hypothesis, EPA slightly increased the immobility time, and in some experiments tended to reduce the anti-despair effect of imipramine.Conclusion:The present results do not provide an animal model for the antidepressant effect of EPA as demonstrated in clinical experiments. The mechanism of EPA antidepressant action is unknown and the Porsolt forced swimming test could be non-sensitive for its antidepressant properties.

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