Influence of calcium phosphates incorporation into poly(lactic-co-glycolic acid) electrospun membranes for guided bone regeneration

The aim of this research is to synthesize polycaprolactone-based polyurethanes (PCL-based PUs) that can be further used for the fabrication of guided bone regeneration (GBR) membranes with higher tensile strength and elongation at break than collagen and PTFE membranes. The PCL-based PUs were prepared by the polymerization of polycaprolactone (PCL) diol with 1,6-hexamethylene diisocyanate (HDI) at different ratios using either polyethylene glycol (PEG) or ethylenediamine (EDA) as chain extenders. The chemical, mechanical, and thermal properties of the synthesized polymers were determined using NMR, FTIR, GPC, DSC, and tensile tester. The PCL and polyurethanes were fabricated as nanofiber membranes by electrospinning, and their mechanical properties and SEM morphology were also investigated. In vitro tests, including WST-1 assay, SEM of cells, and phalloidin cytoskeleton staining, were also performed. It was shown that electrospun membranes made of PCL and PCL-HDI-PEG (2 : 3 : 1) possessed tensile strength of 19.84 MPa and 11.72 MPa and elongation at break of 627% and 362%, respectively. These numbers are equivalent or higher than most of the commercially available collagen and PTFE membrane. As a result, these membranes may have potential for future GBR applications.

Download Full-text

Guided bone regeneration by poly(lactic-co-glycolic acid) grafted hyaluronic acid bi-layer films for periodontal barrier applications

Acta Biomaterialia ◽

10.1016/j.actbio.2009.05.019 ◽

2009 ◽

Vol 5 (9) ◽

pp. 3394-3403 ◽

Cited By ~ 60

Author(s):

Jung Kyu Park ◽

Junseok Yeom ◽

Eun Ju Oh ◽

Mallikarjuna Reddy ◽

Jong Young Kim ◽

...

Keyword(s):

Hyaluronic Acid ◽

Bone Regeneration ◽

Glycolic Acid ◽

Guided Bone Regeneration

Download Full-text

In vitro degradation of triple layered poly (lactic-co-glycolic acid) composite membrane composed of nanoapatite and lauric acid for guided bone regeneration applications

Materials Chemistry and Physics ◽

10.1016/j.matchemphys.2018.09.060 ◽

2019 ◽

Vol 221 ◽

pp. 501-514 ◽

Cited By ~ 4

Author(s):

Jamuna-Thevi Kalitheertha Thevar ◽

Nik Ahmad Nizam Nik Malek ◽

Mohammed Rafiq Abdul Kadir

Keyword(s):

Bone Regeneration ◽

Composite Membrane ◽

Lauric Acid ◽

Glycolic Acid ◽

Guided Bone Regeneration ◽

In Vitro Degradation

Download Full-text

Bilayer Poly(Lactic-co-glycolic acid)/Nano-Hydroxyapatite Membrane with Barrier Function and Osteogenesis Promotion for Guided Bone Regeneration

Materials ◽

10.3390/ma10030257 ◽

2017 ◽

Vol 10 (3) ◽

pp. 257 ◽

Cited By ~ 17

Author(s):

Li Fu ◽

Zhanfeng Wang ◽

Shujun Dong ◽

Yan Cai ◽

Yuxin Ni ◽

...

Keyword(s):

Bone Regeneration ◽

Barrier Function ◽

Glycolic Acid ◽

Guided Bone Regeneration

Download Full-text

HACC modified poly (L-Lactic-co-Glycolic Acid) electrospun fibrous scaffold for guided bone regeneration membrane

Journal of Orthopaedic Translation ◽

10.1016/j.jot.2016.06.159 ◽

2016 ◽

Vol 7 ◽

pp. 124-125

Author(s):

Shengbing Yang ◽

Haiyong Ao ◽

Ying Yang ◽

Tingting Tang

Keyword(s):

Bone Regeneration ◽

Glycolic Acid ◽

Guided Bone Regeneration ◽

Fibrous Scaffold

Download Full-text

Importance of Poly(lactic-co-glycolic acid) in Scaffolds for Guided Bone Regeneration: A Focused Review

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-13-00225 ◽

2015 ◽

Vol 41 (4) ◽

pp. e152-e157 ◽

Cited By ~ 15

Author(s):

Gabriel Castillo-Dalí ◽

Rocío Velázquez-Cayón ◽

M. Angeles Serrera-Figallo ◽

Agustín Rodríguez-González-Elipe ◽

José-Luis Gutierrez-Pérez ◽

...

Keyword(s):

Tissue Engineering ◽

Bone Regeneration ◽

Bone Tissue ◽

Bone Repair ◽

Glycolic Acid ◽

Guided Bone Regeneration ◽

Future Research ◽

Loss Of Function ◽

Important Health

Total or partial tissue damage and loss of function in an organ are two of the most serious and costly issues in human health. Initially, these problems were approached through organ and allogenic tissue transplantation, but this option is limited by the scarce availability of donors. In this manner, new bone for restoring or replacing lost and damaged bone tissue is an important health and socioeconomic necessity. Tissue engineering has been used as a strategy during the 21st century for mitigating this need through the development of guided bone regeneration scaffold and composites. In this manner, compared with other traditional methods, bone tissue engineering offers a new and interesting approach to bone repair. The poly-α-hydroxy acids, which include the copolymers of lactic acid and glycolic acid, have been used commonly in the fabrication of these scaffolds. The objective of our article was to review the characteristics and functions of scaffold with biomedical applications, with special interest in scaffold construction using poly(lactic-co-glycolic acid) polymers, in order to update the current methods used for fabrication and to improve the quality of these scaffolds, integrating this information into the context of advancements made in tissue engineering based on these structures. In the future, research into bone regeneration should be oriented toward a fruitful exchange between disciplines involved in tissue engineering, which is coming very close to filling the gaps in our ability to provide implants and restoration of functionality in bone tissue. Overcoming this challenge will provide benefits to a major portion of the population and facilitate substantial improvements to quality of life.

Download Full-text