Enhanced solubility, dissolution, and absorption of lycopene by a solid dispersion technique: The dripping pill delivery system

2016 ◽  
Vol 301 ◽  
pp. 641-648 ◽  
Author(s):  
Chih-Wei Chang ◽  
Chih-Yuan Wang ◽  
Yu-Tse Wu ◽  
Mei-Chich Hsu
Keyword(s):  
Delivery System ◽  
Solid Dispersion ◽  
Enhanced Solubility ◽  
Dispersion Technique

Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique

1999 ◽  
Vol 187 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Jae-Young Jung ◽  
Sun Dong Yoo ◽  
Sang-Heon Lee ◽  
Kye-Hyun Kim ◽  
Doo-Sun Yoon ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Enhanced Solubility ◽  
Dispersion Technique

scholarly journals A Menthol-Based Solid Dispersion Technique for Enhanced Solubility and Dissolution of Sulfamethoxazole from an Oral Tablet Matrix

2014 ◽  
Vol 16 (4) ◽  
pp. 771-786 ◽  
Author(s):  
Bibi F. Choonara ◽  
Yahya E. Choonara ◽  
Pradeep Kumar ◽  
Lisa C. du Toit ◽  
Lomas K. Tomar ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Oral Tablet ◽  
Enhanced Solubility ◽  
Tablet Matrix ◽  
Dispersion Technique

Enhanced solubility and dissolution rate of lamotrigine by inclusion complexation and solid dispersion technique

2008 ◽  
Vol 60 (9) ◽  
pp. 1121-1129 ◽  
Author(s):  
Vikram R. Shinde ◽  
Makarand R. Shelake ◽  
Sandeep S. Shetty ◽  
Amit B. Chavan-Patil ◽  
Yogesh V. Pore ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Inclusion Complexation ◽  
Enhanced Solubility ◽  
Dispersion Technique

Improvement of Solubility and Dissolution Rate of Simvastatin by Solid Dispersion Technique

2019 ◽  
Vol 12 (6) ◽  
pp. 4964-4700
Author(s):  
Bhikshapathi D.V. R. N. ◽  
Vishwaja M ◽  
Suthakaran R ◽  
Usha Sri B ◽  
M. Ratan Seshagiri Rao
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Drug Dissolution ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Enhanced Solubility ◽  
Percentage Yield ◽  
Dispersion Technique ◽  
The Stability

The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II, percentage yield of 99.13% and dissolution rate of 99.2 ± 2.3% within 90 min is chosen as optimized formulation. The formulation is further Characterized for Drug excipient interaction by FTIR, PXRD and SEM studies. The stability studies for 6 months indicated no significant changes in drug content or drug dissolution rate. Hence, improve dissolution characteristics of Simvastatin achieved by increasing its release and solubility through solid dispersion technique.

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