Enhanced solubility and dissolution rate of lamotrigine by inclusion complexation and solid dispersion technique

The aim of present work is to enhance the solubility and bioavailability of Simvastatin by solid dispersion technique and characterize the same. Preliminary solubility studies were conducted to check the solubility in different polymers. Based on the results 20 formulations prepared by solvent evaporation method with varying ratios of Kleptose HPB, Soluplus, Kolliwax GMS II, Kolliphor P188 and PVPK-30. All the formulations were analyzed for solubility, percentage yield, drug content and in vitro drug release. The formulation SD20 with enhanced solubility of 20.05 ± 0.02μg/mL in Kolliwax GMS II, percentage yield of 99.13% and dissolution rate of 99.2 ± 2.3% within 90 min is chosen as optimized formulation. The formulation is further Characterized for Drug excipient interaction by FTIR, PXRD and SEM studies. The stability studies for 6 months indicated no significant changes in drug content or drug dissolution rate. Hence, improve dissolution characteristics of Simvastatin achieved by increasing its release and solubility through solid dispersion technique.

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Assessment of dissolution profile of Pantoprazole tablets available in Bangladesh

Stamford Journal of Pharmaceutical Sciences ◽

10.3329/sjps.v4i2.10441 ◽

2012 ◽

Vol 4 (2) ◽

pp. 58-62

Author(s):

Aparajita Malakar ◽

Bishwajit Bokshi ◽

Utpal Kumar Karmakar

Keyword(s):

Dissolution Rate ◽

Solid Dispersion ◽

Water Soluble ◽

Dissolution Profile ◽

Coating Materials ◽

Volatile Solvents ◽

Kneading Method ◽

Enhanced Solubility ◽

Materials Used ◽

Liquisolid Compacts

The aim of the present study was to increase the solubility of a poorly water soluble BCS class II drug, valsartan. Liquisolid technology and solid dispersion by kneading method were techniques used to improve the solubility of the drug by using non-volatile solvents and some hydrophilic carriers. Liquisolid compacts were prepared by dissolving the drug in suitable non volatile solvents. The various non volatile solvents used were PG, PEG, and glycerine. The carrier coating materials play an important role in improving the solubility of the drug. The dissolution rate of the drug was increased by using propylene glycol as non-volatile solvent at 20:1 ratio of carrier to coating material. Solid dispersion by kneading method were another attempt to improve solubility the various carrier materials used were PVP K 30, PEG 6000 and mannitol, these carriers are used in various ratios to improve its solubility. The dissolution rate of drug using solid dispersion kneading method with mannitol was increased at 1:3 ratio. The DSC and FTIR studies revealed no drug excipients interactions, whereas XRD revealed the reduced crystalinity of drug, which showed enhanced solubility. From the results it was concluded that the liquisolid compacts enhanced the solubility of valsartan in comparison to traditional solid dispersion method.DOI: http://dx.doi.org/10.3329/sjps.v4i2.10441 S. J. Pharm. Sci. 4(2) 2011: 58-62

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Improvement of dissolution rate of tacrolimus by solid dispersion technique

Journal of Pharmaceutical Investigation ◽

10.1007/s40005-013-0053-8 ◽

2013 ◽

Vol 43 (1) ◽

pp. 45-53 ◽

Cited By ~ 5

Author(s):

Pranav V. Patel ◽

Shital S. Panchal ◽

Tejal A. Mehta

Keyword(s):

Dissolution Rate ◽

Solid Dispersion ◽

Dispersion Technique

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Enhancement of Solubility and Dissolution Rate of Indomethacin by Chitosan Based Solid Dispersion Technique.

Journal of Current Pharma Research ◽

10.33786/jcpr.2015.v05i02.008 ◽

2015 ◽

Vol 5 (2) ◽

pp. 1463-1472 ◽

Cited By ~ 1

Author(s):

Shete A.S . ◽

Yadav V.B . ◽

Sakhare S.S . ◽

Patil S.B . ◽

Sajane S.J . ◽

...

Keyword(s):

Dissolution Rate ◽

Solid Dispersion ◽

Dispersion Technique

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Solid Dispersions : An Approach to Enhance the Bioavailability of Poorly Water-Soluble Drugs

International Journal of Pharmacology and Pharmaceutical Technology ◽

10.47893/ijppt.2013.1006 ◽

2013 ◽

pp. 37-46

Author(s):

Sanjoy Kumar Das

Keyword(s):

Dissolution Rate ◽

Solid Dispersion ◽

Solid Dispersions ◽

Water Soluble ◽

Historical Background ◽

Solid Dosage ◽

Advantages And Disadvantages ◽

Water Soluble Drugs ◽

Inert Carrier ◽

Dispersion Technique

Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic inert carrier or matrix and a hydrophobic drug. This article reviews historical background of solid dispersion technology, limitations, classification, and various preparation techniques with its advantages and disadvantages. This review also discusses the recent advances in the field of solid dispersion technology. Based on the existing results and authors’ reflection, this review give rise to reasoning and suggested choices of carrier or matrix and solid dispersion procedure.

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Enhancing dissolution profile of diazepam using hydrophilic polymers by solid dispersion technique

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i12.12453 ◽

2012 ◽

Vol 1 (12) ◽

pp. 423-430 ◽

Cited By ~ 3

Author(s):

Md. Sariful Islam Howlader ◽

Jayanta Kishor Chakrabarty ◽

Khandokar Sadique Faisal ◽

Uttom Kumar ◽

Md. Raihan Sarkar ◽

...

Keyword(s):

Dissolution Rate ◽

Solid Dispersion ◽

Solid Dispersions ◽

Water Soluble ◽

Distilled Water ◽

Dissolution Profile ◽

Peg 6000 ◽

Solvent Method ◽

Pure Drug ◽

Dispersion Technique

The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug by a solid dispersion technique, in order to investigate the effect of these polymers on release mechanism from solid dispersions. Diazepam was used as a model drug to evaluate its release characteristics from different matrices. Solid dispersions were prepared by using polyethylene glycol 6000 (PEG-6000), HPMC, HPC and Poloxamer in different drug-to-carrier ratios (1:2, 1:4, 1:6, 1:8, 1:10). The solid dispersions were prepared by solvent method. The pure drug and solid dispersions were characterized by in vitro dissolution study. Distilled water was used as dissolution media, 1000 ml of distilled water was used as dissolution medium in each dissolution basket at a temperature of 37°C and a paddle speed of 100 rpm. The very slow dissolution rate was observed for pure Diazepam and the dispersion of the drug in the polymers considerably enhanced the dissolution rate. This can be attributed to improved wettability and dispersibility, as well as decrease of the crystalline and increase of the amorphous fraction of the drug. SEM (Scanning Electron microscope) studies shows that the solid dispersion having a uniform dispersion. Solid dispersions prepared with PEG-6000, Poloxamer showed the highest improvement in wettability and dissolution rate of Diazepam. Solid dispersion containing polymer prepared with solvent method showed significant improvement in the release profile as compared to pure drug, Diazepam.DOI: http://dx.doi.org/10.3329/icpj.v1i12.12453 International Current Pharmaceutical Journal 2012, 1(12): 423-430

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