scholarly journals Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis

2020 ◽  
Vol 76 ◽  
pp. 100826 ◽  
Author(s):  
Rahul A. Jonas ◽  
Lawson Ung ◽  
Jaya Rajaiya ◽  
James Chodosh
Keyword(s):  
Human Adenovirus ◽  
Epidemic Keratoconjunctivitis

scholarly journals Novel Human Adenovirus Causing Nosocomial Epidemic Keratoconjunctivitis

2008 ◽  
Vol 46 (6) ◽  
pp. 2002-2008 ◽  
Author(s):  
H. Ishiko ◽  
Y. Shimada ◽  
T. Konno ◽  
A. Hayashi ◽  
T. Ohguchi ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Epidemic Keratoconjunctivitis

scholarly journals Decoy Receptor Interactions as Novel Drug Targets against EKC-Causing Human Adenovirus

Viruses ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 242 ◽  
Author(s):  
Naresh Chandra ◽  
Lars Frängsmyr ◽  
Niklas Arnberg
Keyword(s):  
Drug Targets ◽  
Antiviral Drug ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Antiviral Effect ◽  
Epidemic Keratoconjunctivitis ◽  
Virus Binding ◽  
Decoy Receptor ◽  
Decoy Receptors ◽  
Approved Drugs

Epidemic keratoconjunctivitis (EKC) is a severe ocular disease and can lead to visual impairment. Human adenovirus type-37 (HAdV-D37) is one of the major causative agents of EKC and uses sialic acid (SA)-containing glycans as cellular receptors. Currently, there are no approved antivirals available for the treatment of EKC. Recently, we have reported that sulfated glycosaminoglycans (GAGs) bind to HAdV-D37 via the fiber knob (FK) domain of the viral fiber protein and function as decoy receptors. Based on this finding, we speculated that GAG-mimetics may act as artificial decoy receptors and inhibit HAdV-D37 infection. Repurposing of approved drugs to identify new antivirals has drawn great attention in recent years. Here, we report the antiviral effect of suramin, a WHO-approved drug and a widely known GAG-mimetic, against HAdV-D37. Commercially available suramin analogs also show antiviral effects against HAdV-D37. We demonstrate that suramin exerts its antiviral activity by inhibiting the attachment of HAdV-D37 to cells. We also reveal that the antiviral effect of suramin is HAdV species-specific. Collectively, in this proof of concept study, we demonstrate for the first time that virus binding to a decoy receptor constitutes a novel and an unexplored target for antiviral drug development.

scholarly journals Epidemic Keratoconjunctivitis Due to the Novel Hexon-Chimeric-Intermediate 22,37/H8 Human Adenovirus

2008 ◽  
Vol 46 (10) ◽  
pp. 3259-3269 ◽  
Author(s):  
K. Aoki ◽  
H. Ishiko ◽  
T. Konno ◽  
Y. Shimada ◽  
A. Hayashi ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
The Novel ◽  
Epidemic Keratoconjunctivitis

scholarly journals Notes from the Field: Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 — U.S. Virgin Islands, June–November 2016

2017 ◽  
Vol 66 (30) ◽  
pp. 811-812 ◽  
Author(s):  
Marie E. Killerby, ◽  
Matthew J. Stuckey, ◽  
Irene Guendel, ◽  
Senthilkumar Sakthivel, ◽  
Xiaoyan Lu, ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Adenovirus Type ◽  
Virgin Islands ◽  
Epidemic Keratoconjunctivitis

scholarly journals Five Cases of Epidemic Keratoconjunctivitis Due to Human Adenovirus Type 85 in Fukushima, Japan

2020 ◽  
Vol 73 (4) ◽  
pp. 316-319
Author(s):  
Hisatoshi Kaneko ◽  
Nozomu Hanaoka ◽  
Masami Konagaya ◽  
Masaaki Kobayashi ◽  
Hisashi Nakagawa ◽  
...  
Keyword(s):  
Human Adenovirus ◽  
Adenovirus Type ◽  
Epidemic Keratoconjunctivitis

scholarly journals Virology and epidemiology analyses of global adenovirus-associated conjunctivitis outbreaks, 1953–2013

2016 ◽  
Vol 144 (8) ◽  
pp. 1661-1672 ◽  
Author(s):  
L. ZHANG ◽  
N. ZHAO ◽  
J. SHA ◽  
C. WANG ◽  
X. JIN ◽  
...  
Keyword(s):  
United States ◽  
Phylogenetic Analysis ◽  
Surveillance System ◽  
Common Ancestor ◽  
Human Adenovirus ◽  
The United States ◽  
Seasonal Distribution ◽  
Early Winter ◽  
Epidemic Keratoconjunctivitis ◽  
The World

SUMMARYThis study aimed to compare the virology and epidemiology of epidemic keratoconjunctivitis (EKC), pharyngoconjunctival fever (PCF) and acute haemorrhagic conjunctivitis (AHC) outbreaks worldwide caused by the human adenovirus (HAdV) from 1953 to 2013. Eighty-three hexon sequences from 76 conjunctivitis outbreaks were analysed and subtyped using Mega 5.05, Clustal X and SimPlot software. Epidemiology was performed for the area, age and seasonal distribution. A phylogenetic analysis indicated that all the isolates could be divided into three subgenetic lineages, without a common ancestor. The major causes of the outbreaks were Ad8, Ad7 and Ad2 co-infection with enterovirus 70 (EV70) in EKC, PCF and AHC, respectively. The epidemiological findings suggested that EKC and AHC were circulating predominantly in Asia during the early winter and spring, whereas PCF was circulating mainly in China, Australia and the United States during the summer. This study suggests that EKC, AHC and PCF outbreaks have different circulating patterns throughout the world and are caused by different adenovirus serotypes. A global surveillance system should be established to monitor conjunctivitis outbreaks in the future.

scholarly journals Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate

2019 ◽  
pp. 112067211989140 ◽  
Author(s):  
Mei Hashizume ◽  
Koki Aoki ◽  
Shigeaki Ohno ◽  
Nobuyoshi Kitaichi ◽  
Nobuyo Yawata ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Viral Genome ◽  
A549 Cells ◽  
Human Adenovirus ◽  
Polymerase Chain Reaction Analysis ◽  
Chain Reaction ◽  
Epidemic Keratoconjunctivitis ◽  
Polymerase Chain ◽  
Potassium Peroxymonosulfate

Purpose: The aim of this study was to test the antiviral effectivity of potassium peroxymonosulfate (RUBYSTA®, KYORIN) against five epidemic keratoconjunctivitis-related types of Human adenovirus D in vitro. Methods: Five types of Human adenovirus D (8, 37, 53, 54 and 56) were incubated with 1% potassium peroxymonosulfate, 0.1% sodium hypochlorite (NaClO) or alcohol-based disinfectant for 30 s or 1 min. These solutions were subjected to measurements of viral titres by infection assays in A549 cells. At day 6 post-infection, both, supernatants and cells, were collected and the viral genome was assessed by real-time polymerase chain reaction analysis. Results: Treatments with 1% potassium peroxymonosulfate led to significant reduction in all tested Human adenovirus D types comparable to disinfecting effects by 0.1% NaClO. Overall, potassium peroxymonosulfate demonstrated sufficient inactivation of the major epidemic keratoconjunctivitis-causing Human adenovirus D to be considered for disinfection and prevention purposes in ophthalmological clinics and hospitals. Conclusion: This study demonstrated that potassium peroxymonosulfate is a promising disinfectant for the prevention of epidemic keratoconjunctivitis nosocomial infections in ophthalmological clinics.

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