Clinical vision and molecular loss: Integrating visual psychophysics with molecular genetics reveals key details of normal and abnormal visual processing

2017 ◽

Vol 31 (4) ◽

pp. 272-284

Author(s):

Francesca Beilharz ◽

Susan L. Rossell

Keyword(s):

Visual Processing ◽

Body Dysmorphic Disorder ◽

Behavioral Therapy ◽

Treatment Options ◽

Adjunctive Treatment ◽

Exposure And Response Prevention ◽

The Core ◽

Exposure Tasks ◽

Abnormal Visual ◽

Visual Abnormalities

Recent psychophysical and neurocognitive findings implicate abnormal visual processing for a range of stimuli in body dysmorphic disorder (BDD); such abnormalities differentiate BDD from other mental health disorders. Current treatments most commonly involve cognitive behavior therapy with or without accompanying antidepressant medications. These are moderately successful yet appear to overlook the core phenomenological aspect of abnormal perception in BDD. The following text summarizes the current literature of perceptual abnormalities within BDD and how these findings may be applied and incorporated into treatment options. Possible modifications of cognitive behavioral therapy (CBT) based on the widespread visual abnormalities within BDD include making perceptual mirror retraining a compulsory component of therapy and implementing self-exposure tasks within exposure and response prevention. Alternative options such as a visual training program to remediate visual abnormalities across a range of visual stimuli are also explored, which may be included as an adjunctive treatment alongside CBT.

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A reinterpretation of critical flicker-frequency (CFF) data reveals key details about light adaptation and normal and abnormal visual processing

Progress in Retinal and Eye Research ◽

10.1016/j.preteyeres.2021.101001 ◽

2021 ◽

pp. 101001

Author(s):

Andrew T. Rider ◽

G. Bruce Henning ◽

Andrew Stockman

Keyword(s):

Visual Processing ◽

Light Adaptation ◽

Critical Flicker Frequency ◽

Flicker Frequency ◽

Abnormal Visual

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Abnormal visual processing and increased seizure susceptibility result from developmental exposure to the biocide methylisothiazolinone

Neuroscience ◽

10.1016/j.neuroscience.2011.12.052 ◽

2012 ◽

Vol 205 ◽

pp. 194-204 ◽

Cited By ~ 8

Author(s):

A. Spawn ◽

C.D. Aizenman

Keyword(s):

Visual Processing ◽

Seizure Susceptibility ◽

Developmental Exposure ◽

Abnormal Visual

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Binocular integration of perceptually suppressed visual information in amblyopia

10.1101/2020.06.04.20122440 ◽

2020 ◽

Author(s):

Amy Chow ◽

Andrew E. Silva ◽

Katelyn Tsang ◽

Gabriel Ng ◽

Cindy Ho ◽

...

Keyword(s):

Visual Processing ◽

Visual Information ◽

Critical Period ◽

Visual Experience ◽

Early Stage ◽

Neurodevelopmental Disorder ◽

Conscious Awareness ◽

Interocular Suppression ◽

Abnormal Visual ◽

The Brain

Abnormal visual experience during an early critical period of visual cortex development can lead to a neurodevelopmental disorder of vision called amblyopia. A key feature of amblyopia is interocular suppression, whereby information from the amblyopic eye is blocked from conscious awareness when both eyes are open. Suppression of the amblyopic eye is thought to occur at an early stage of visual processing and to be absolute. Using a binocular rivalry paradigm, we demonstrate that suppressed visual information from the amblyopic eye remains available for binocular integration and can influence overall perception of stimuli. This finding reveals that suppressed visual information continues to be represented within the brain even when it is blocked from conscious awareness by chronic pathological suppression. These results have direct implications for the clinical management of amblyopia.

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Abnormal visual processing in migraine with aura: A study of steady-state visual evoked potentials

Journal of the Neurological Sciences ◽

10.1016/j.jns.2008.04.004 ◽

2008 ◽

Vol 271 (1-2) ◽

pp. 119-126 ◽

Cited By ~ 26

Author(s):

Koichi Shibata ◽

Kiyomi Yamane ◽

Kuniaki Otuka ◽

Makoto Iwata

Keyword(s):

Steady State ◽

Evoked Potentials ◽

Migraine With Aura ◽

Visual Evoked Potentials ◽

Visual Processing ◽

Abnormal Visual ◽

Visual Evoked

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Introduction

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100070266 ◽

1978 ◽

Vol 36 (3) ◽

pp. 543-544

Author(s):

W. Bernard

Keyword(s):

Molecular Weight ◽

Electron Microscope ◽

Nucleic Acid ◽

Gene Mapping ◽

Molecular Genetics ◽

Cell Biology ◽

Gene Activity ◽

Close Connection ◽

Basic Information ◽

Simple Systems

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.

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