12/15-Lipoxygenase gene disruption and Vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway

2005 ◽  
Vol 78 (1-4) ◽  
pp. 185-193 ◽  
Author(s):  
Lei Zhao ◽  
Domenico Praticò ◽  
Daniel J. Rader ◽  
Colin D. Funk
2002 ◽  
Vol 123 (8) ◽  
pp. 1121-1131 ◽  
Author(s):  
ZhongMao Guo ◽  
Felicia Mitchell-Raymundo ◽  
Hong Yang ◽  
Yuji Ikeno ◽  
James Nelson ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (107) ◽  
pp. 105363-105370 ◽  
Author(s):  
Xiao Mingzhu ◽  
Jin Xiaobao ◽  
Tang Futian ◽  
Wang Lijing ◽  
Mao Jianwen ◽  
...  

Despitemany therapeutic advances, atherosclerosis remains the leading cause of morbidity and mortality in developed countries.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2807-2813
Author(s):  
Resmi C R ◽  
Kedari G S R ◽  
Deepa P K

CAD is recognized as a multifactorial disease that is influenced by environmental and genetic factors. This study aimed to evaluate the levels of lipid parameters, oxidative stress and antioxidant markers in subjects with CAD compared to their age & sex matched controls and to analyze the relationship between atherogenic Index and oxidative stress among them 62 clinically proved CAD patients and 62 healthy age and sex matched subjects without CAD were selected for this study. 5 ml of fasting venous blood was collected from all the subjects and investigations such as FPG, lipid profile, oxidative markers Malondialdehyde (MDA), F2 isoprostanes (F2iso) and antioxidants glutathione S-transferase (GST), superoxide dismutase (SOD), vitamin-C, vitamin-E were performed. This study showed that levels of lipid parameters total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and AI were significantly higher whereas high density lipoprotein cholesterol (HDL-c) were significantly low in CAD patients compared to normal controls. Oxidative stress markers MDA and F2 Isoprostanes level were significantly high, whereas enzymatic antioxidants GST and SOD and non-enzymatic antioxidants Vitamin-C and Vitamin-E levels were significantly low in CAD patients. Oxidative stress markers were found to significantly influence the AI. Results of this study showed that oxidative stress markers F2iso and MDA and antioxidants GST, VIT-C and VIT-E are found to influence the atherogenic index significantly.


2005 ◽  
Vol 167 (5) ◽  
pp. 1371-1377 ◽  
Author(s):  
Cinzia M. Chinnici ◽  
Yuemang Yao ◽  
Tao Ding ◽  
Colin D. Funk ◽  
Domenico Praticò

Nutrition ◽  
2001 ◽  
Vol 17 (10) ◽  
pp. 809-814 ◽  
Author(s):  
Jennifer M. Sacheck ◽  
Jeffrey B. Blumberg

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