E-cadherin expression in upper urothelial carcinoma in Balkan Endemic Nephropathy and non-endemic regions

2009 ◽  
Vol 205 (10) ◽  
pp. 682-689 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Milan Visnjic ◽  
Irena Dimov ◽  
Mariola Stojanovic ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy ◽  
E Cadherin

scholarly journals Molecular Markers in Upper Urothelial Carcinoma Associated to Balkan Endemic Nephropathy. Aristolochic Acid as the Major Risk Factor of the Worldwide Disease

2009 ◽  
Vol 9 ◽  
pp. 1360-1373 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Vladisav Stefanovic
Keyword(s):  
Regression Analysis ◽  
Urothelial Carcinoma ◽  
Growth Stage ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Specific Cell ◽  
Ki 67 ◽  
High Stage ◽  
Endemic Nephropathy

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the grade and multifocality (p< 0.05), but in regression analysis, only the grade of BEN tumor. The p53 index was significantly higher in BEN than in control tumors (p< 0.05), as well as the alteration of p53 (p< 0.05). BEN low-stage tumors, tumors without limphovascular invasion (LVI), and tumors of the renal pelvis had a higher p53 index than the control tumors (p< 0.05, 0.01, 0.05, respectively). The Ki-67 index was higher in control tumors with high-stage and solid growth than in BEN UUC (p < 0.050, 0.005). The Ki-67 correlated with the grade, growth, stage, LVI, and multifocality of UUC on the best way, but not with the group. In regression analysis, only multifocality of UUC had predictive influence on Ki-67 activity (p< 0.001). P53 correlated with the grade, growth, and group (p< 0.05). This investigation identifies the p53 pathway as the specific cell cycle marker involved in BEN-associated UUC.

scholarly journals MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Katerina Popovska-Jankovic ◽  
Predrag Noveski ◽  
Ljubinka Jankovic-Velickovic ◽  
Slavica Stojnev ◽  
Rade Cukuranovic ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Strong Association ◽  
Upper Tract Urothelial Carcinoma ◽  
Danube River ◽  
Balkan Endemic Nephropathy ◽  
Upper Tract ◽  
Microrna Profiling ◽  
Endemic Nephropathy ◽  
Urothelial Bladder ◽  
Balkan Region

Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region. BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC). There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease. Aberrantly expressed miRNAs have been shown to be associated with many types of cancers. A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC. Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues. We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC. miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups.

Upper urothelial carcinoma in Balkan endemic nephropathy and non-endemic regions: A comparative study of pathological features

2009 ◽  
Vol 205 (2) ◽  
pp. 89-96 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Zana Dolicanin ◽  
Milan Visnjic ◽  
Miljan Krstic ◽  
...  
Keyword(s):  
Comparative Study ◽  
Urothelial Carcinoma ◽  
Balkan Endemic Nephropathy ◽  
Pathological Features ◽  
Endemic Nephropathy

Characteristics of Upper Urothelial Carcinoma in an Area of Balkan Endemic Nephropathy in South Serbia. A fifty-year Retrospective Study

2010 ◽  
Vol 96 (5) ◽  
pp. 674-679 ◽  
Author(s):  
Rade Cukuranovic ◽  
Ivan Ignjatovic ◽  
Milan Visnjic ◽  
Ljubinka Jankovic Velickovic ◽  
Branislav Petrovic ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Urothelial Carcinoma ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy

scholarly journals Simultaneous ipsilateral rhabdoid renal cell carcinoma and multifocal urothelial carcinoma of the ureter in a patient from the region of Balkan endemic nephropathy: Case report and literature review

2021 ◽  
pp. 1-1
Author(s):  
Dragoslav Basic ◽  
Ljubinka Jankovic-Velickovic ◽  
Ivan Ignjatovic ◽  
Jovan Hadzi-Djokic ◽  
Andrej Veljkovic
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Literature Review ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Purulent Discharge ◽  
Balkan Endemic Nephropathy ◽  
Endemic Nephropathy ◽  
The Right

Introduction. Simultaneous ipsilateral coexistence of renal cell carcinoma (RCC) and upper urinary tract urothelial carcinoma (UTUC) rarely occurs. Balkan endemic nephropathy (BEN) is a chronic degenerative tubulointerstitial renal disease, strongly associated with UTUC. Case outline. ? 60-year-old man from the region of BEN was referred to our clinic due to right flank pain, fever, and purulent discharge from the cutaneous fistulous opening in the right lumbar area. Multislice computed tomography urography scan showed right-side pyonephrosis and nephrocutaneous fistulous tract between the kidney and the skin in the right lumbar region. Cystoscopy detected papillary tumor protruding from the right ureteric orifice. Right-side nephroureterectomy with bladder cuff excision (BCE) was performed. Histopathological examination revealed rhabdoid RCC of the kidney and multifocal urothelial carcinoma of the ureter. Conclusion. Our case report and literature review indicate that due to rising incidence of multiple primary malignant neoplasms, when treating patients with RCC or UTUC, and especially those from the region of BEN, one should keep in mind the likelihood of synchronous or metachronous occurrence of these tumors.

scholarly journals Pro- and Antiapoptotic Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy

2011 ◽  
Vol 11 ◽  
pp. 1699-1711 ◽  
Author(s):  
Ljubinka Jankovic-Velickovic ◽  
Slavica Stojnev ◽  
Ana Ristic-Petrovic ◽  
Zana Dolicanin ◽  
Takanori Hattori ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Balkan Endemic Nephropathy ◽  
Specific Marker ◽  
High Grade ◽  
Apoptotic Pathway ◽  
Altered Expression ◽  
Upper Tract ◽  
Control Stage ◽  
Endemic Nephropathy

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper-tract urothelial carcinoma (UTUC) has been recently confirmed. The aim of this study was to determine apoptosis-related marker(s) specific for BEN-associated UTUC. Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors. Altered expression of Survivin was more often present in BEN UTUC with high grade and solid growth (P<0.005;P<0.05) than in control tumors. Significantly lower expression of proapoptotic marker Bax was found in BEN tumors with high grade, high stage, necrosis, and without metaplastic change (P<0.05; 0.05; 0.05; 0.05) compared to control tumors with the same features. Group (BEN-related/control), stage, growth pattern, and caspase 3 activity were significantly associated with the expression of Bax (P=0.002, 0.034, 0.047, 0.028, resp.,). This investigation identifies Bax as specific marker of BEN-associated UTUC. Decrease of pro-apoptotic protein Bax together with alteration of Survivin may be indicative for specific disturbances of intrinsic apoptotic pathway in UTUC arising in endemic areas.

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