Characterization of Underrepresented Populations in Modern Era Clinical Trials Involving Radiation Therapy

1544 Background: RTOG trials in the 1970’s established WBRT (3000 cGy/10 fractions) as an effective palliative tool for symptomatic BM. This was in the era before CT/ MRI and effective systemic therapy. Inclusion criteria was based on clinical symptoms, and studies such as EEG and arteriography though not required. This study was undertaken to determine if pts. in the modern era are similar to those aforementioned, since it may not be appropriate to use accelerated WBRT (aWBRT) in these pts. based on the RTOG guidelines if the cohorts are different. (Other issues such as delayed cognitive dysfunction, alopecia and the impact of and integration with systemic therapy are pertinent to the application and prescription of aWBRT, but not the focus of this study). Methods: A retrospective chart review of 414 consecutive pts. with BM treated with radiation therapy in a single practice from 1990 through 2004 form the basis of this study. There were 256 females and 158 males. Lung cancer was the most common primary site (249/60%) and breast cancer next (75/18%). 121 pts (29%) had a single brain metastsis. 66 symptomatic patients underwent surgical resection of a brain metastasis prior to WBRT. The use of CT or MRI was determined. Results: Of the 414 pts, 105 were asymptomatic (25%). An additonal 66 pts. were rendered asymptomatic with surgical resection. Therefore, a total of 171 (40%) pts. were asymptomatic. All pts underwent imaging with CT (132) or MRI (282). Conclusions: Many pts. with BM seen in a modern radiation oncology practice are different from those in the RTOG series’ in which pts. were designated to receive aWBRT. 1. A notable proportion (40%) of a large number of pts. treated since 1990 for BM was asymptomatic vs. none of the pts. in the RTOG trials. 2. All pts. in this series underwent direct imaging vs. none in the RTOG series’. The systematic prescription of aWBRT for all pts. with BM as dictated by RTOG studies in the 1970’s may not be appropriate and alternative strategies and clinical trials are warranted. No significant financial relationships to disclose.

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Faculty Opinions recommendation of Lumpectomy Plus Hormone or Radiation Therapy Alone for Women Aged 70 Years or Older With Hormone Receptor-Positive Early Stage Breast Cancer in the Modern Era: An Analysis of the National Cancer Database.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.736343660.793574002 ◽

2020 ◽

Author(s):

Lorenzo Livi ◽

Isacco Desideri

Keyword(s):

Breast Cancer ◽

Radiation Therapy ◽

Hormone Receptor ◽

Early Stage ◽

Early Stage Breast Cancer ◽

National Cancer Database ◽

Hormone Receptor Positive ◽

Modern Era

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Nadir Prostate-Specific Antigen After Neoadjuvant Androgen Suppression (AS) in Prostate Cancer Patients Receiving Short-term AS and Radiation Therapy: Pooled Analysis of Four NRG Oncology/RTOG Randomized Clinical Trials

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2015.07.111 ◽

2015 ◽

Vol 93 (3) ◽

pp. S46

Author(s):

C.L. Hallemeier ◽

P. Zhang ◽

T.M. Pisansky ◽

G.E. Hanks ◽

D.G. McGowan ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Trials ◽

Radiation Therapy ◽

Cancer Patients ◽

Prostate Specific Antigen ◽

Randomized Clinical Trials ◽

Specific Antigen ◽

Pooled Analysis ◽

Short Term ◽

Androgen Suppression

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Analysis of Clinical Trials in Radiation Oncology: A Systematic Characterization of the Clinicaltrials.gov Database

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2014.05.1750 ◽

2014 ◽

Vol 90 (1) ◽

pp. S581-S582 ◽

Cited By ~ 3

Author(s):

N. Cihoric ◽

A. Tsikkinis ◽

D.M. Aebersold ◽

K. Lössl ◽

K. Zaugg

Keyword(s):

Clinical Trials ◽

Radiation Oncology

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Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration

Annals of Oncology ◽

10.1093/annonc/mdv161 ◽

2015 ◽

Vol 26 (7) ◽

pp. 1280-1291 ◽

Cited By ~ 95

Author(s):

V. Bossuyt ◽

E. Provenzano ◽

W.F. Symmans ◽

J.C. Boughey ◽

C. Coles ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Trials ◽

Residual Disease

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Abstract PO-036: Immunological characterization of mouse HR+ mammary tumors relapsing after radiation therapy

10.1158/1557-3265.radsci21-po-036 ◽

2021 ◽

Author(s):

Norma Bloy ◽

Aitziber Buque ◽

Giulia Petroni ◽

Takahiro Yamazaki ◽

Ai Sato ◽

...

Keyword(s):

Radiation Therapy ◽

Mammary Tumors ◽

Immunological Characterization

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A review on phyto-pharmacology of Oxalis corniculata

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207324666210813121431 ◽

2021 ◽

Vol 24 ◽

Author(s):

Iqra Sarfraz ◽

Azhar Rasul ◽

Ghulam Hussain ◽

Muhammad Ajmal Shah ◽

Bushra Nageen ◽

...

Keyword(s):

Clinical Trials ◽

Biological Activities ◽

Chemical Constituents ◽

Current Effort ◽

Isolation And Characterization ◽

Anti Cancer ◽

Anti Oxidant ◽

Anti Fungal ◽

Warm Temperate

: Oxalis corniculata (Oxalidaceae) is a small decumbent and delicate appearing medicinal herb flourishing in warm temperate and tropical domains such as Pakistan and India. Main bioactive chemical constituents of Oxalis plant include several alkaloids, flavonoids, terpenoids, cardiac glycosides, saponins, phlobatannins along with steroids. Due to its polyphenolic, glycosides and flavonoid profile, it is proved to be protective in numerous ailments and exhibit various biological activities such as anti-fungal, anti-cancer, anti-oxidant, anti-bacterial, anti-diabetic, and cardioprotective. Moreover, bioactive phytochemicals from this plant possess significant wound healing potential. Our current effort intends to emphasize on the immense significance of this plant species, which have not been the subject matter of clinical trials and effective pharmacological studies, even though its favored usage has been stated. This review proposes that Oxalis corniculata possess potential for the cure of various diseases, however, further researches on isolation and characterization of bioactive compounds along with pre-clinical trials are compulsory to figure out its pharmacological applications.

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