Dorsolateral prefrontal cortex morphology and short-term outcome in first-episode schizophrenia

2005 ◽  
Vol 140 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Konasale M.R. Prasad ◽  
Sarah D. Sahni ◽  
Brian R. Rohm ◽  
Matcheri S. Keshavan
2004 ◽  
Vol 185 (3) ◽  
pp. 205-214 ◽  
Author(s):  
A. Mendrek ◽  
K. R. Laurens ◽  
K. A. Kiehl ◽  
E. T. C. Ngan ◽  
E. Stip ◽  
...  

BackgroundA number of functional brain abnormalities have been reported in schizophrenia, but it remains to be determined which of them represent trait and state markers of the illness.AimsTo delineate regional brain dysfunctions that remain stable and those that fluctuate during the course of schizophrenia.MethodA cohort of patients with first-episode schizophrenia and a matched group of control participants underwent functional magnetic resonance imaging on two occasions 6–8 weeks apart during performance of a working memory task. The patients' disease was in partial remission at the second scan.ResultsRelative to control participants, the function of the left dorsolateral prefrontal cortex, left thalamus and right cerebellum remained disturbed in the people with schizophrenia, whereas the dysfunction of the right dorsolateral prefrontal cortex, right thalamus, left cerebellum and cingulate gyrus normalised, with significant reduction in symptoms.ConclusionsThese results suggest that dysfunction of the left fronto-thalamo-cerebellar circuitry is a relatively stable characteristic of schizophrenia, whereas disturbance of the right circuitry and cingulate gyrus is predominantly a state-related phenomenon.


2013 ◽  
Vol 2 ◽  
pp. 590-599 ◽  
Author(s):  
Tyler A. Lesh ◽  
Andrew J. Westphal ◽  
Tara A. Niendam ◽  
Jong H. Yoon ◽  
Michael J. Minzenberg ◽  
...  

2016 ◽  
Vol 134 (4) ◽  
pp. 321-328 ◽  
Author(s):  
A. Thompson ◽  
S. Marwaha ◽  
C. Winsper ◽  
L. Everard ◽  
P. B. Jones ◽  
...  

2009 ◽  
Vol 113 (2-3) ◽  
pp. 129-137 ◽  
Author(s):  
Immaculada Baeza ◽  
Montserrat Graell ◽  
Dolores Moreno ◽  
Josefina Castro-Fornieles ◽  
Mara Parellada ◽  
...  

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