Relationship between pretreatment laboratory-measured episodes of reactive hypoglycemia and short-term weight restoration in anorexia nervosa: A preliminary study

2006 ◽  
Vol 31 (4) ◽  
pp. 452-458 ◽  
Author(s):  
Daisuke Yasuhara ◽  
Shinya Kojima ◽  
Tetsuro Naruo ◽  
Akio Inui
2007 ◽  
Vol 292 (5) ◽  
pp. E1441-E1446 ◽  
Author(s):  
Kimberly P. Kinzig ◽  
Janelle W. Coughlin ◽  
Graham W. Redgrave ◽  
Timothy H. Moran ◽  
Angela S. Guarda

Prolonged malnutrition in individuals with anorexia nervosa (AN) has been associated with alterations in endocrine function that may play a sustaining role in the disorder. We hypothesized that abnormalities in endocrine responses to ingestion of a meal in AN are reversible and depend on weight restoration. We measured meal-induced endocrine responses in AN subjects at three time points during hospitalization: before refeeding ( n = 13, mean BMI 16.7 kg/m2), after 2 wk of refeeding (mean BMI 18.0 kg/m2), and in the weight-restored state (mean BMI 20.3 kg/m2). Control subjects ( n = 13, BMI 19–24.9 kg/m2) were tested once. Tests were 2.5-h sessions in which blood was drawn every 15 min before, during, and after a ∼650-kcal test breakfast. Relative to controls, peak levels of glucose were depressed and peak levels of insulin in response to ingestion of the test meal were delayed, with response patterns in the third trial most similar to controls. Pancreatic polypeptide (PP) levels were increased in AN relative to controls regardless of weight status. The delay in insulin release and elevated PP levels did not correct with short-term refeeding and may contribute to the high relapse rates and maintenance of AN.


2021 ◽  
Vol 12 ◽  
Author(s):  
Graham W. Redgrave ◽  
Colleen C. Schreyer ◽  
Janelle W. Coughlin ◽  
Laura K. Fischer ◽  
Allisyn Pletch ◽  
...  

Proposed treatments for severe and enduring anorexia nervosa (SE-AN) focus on quality of life, and psychological and social functioning. By de-emphasizing weight restoration as a priority, however, premature diagnosis of SE-AN may reduce potential for recovery. The present study assessed the effect of weight restoration, illness duration, and severity on treatment outcome 6 months after discharge from an intensive, meal-based behavioral treatment program. Participants included hospitalized adult women (N = 191) with AN or underweight other specified feeding and eating disorder (OSFED). Participants were characterized as short-term (ill <7 years; n = 74) or long-term ill (ill ≥ 7 years; n = 117). Compared with short-term ill, long-term ill patients were older, had lower lifetime body mass index (BMI), more prior admissions, and exhibited greater depression and neuroticism. Long-term vs. short-term ill patients gained weight at the same rate (~2 kg/wk) and were equally likely to be weight restored by discharge (>75% reached BMI ≥ 19 kg/m2 in both groups). At 6-month follow-up (n = 99), both groups had equivalent self-reported BMI, and depression, drive for thinness, body dissatisfaction, and bulimia scores. The only predictor of BMI ≥ 19 kg/m2 at follow-up was discharge BMI. The likelihood of a BMI ≥ 19 kg/m2 at follow-up was 5-fold higher for those with discharge BMI ≥ 19 kg/m2. Few studies of long-term ill inpatients with AN have examined the impact of full weight restoration on short-term outcomes. This study supports the therapeutically optimistic stance that, regardless of illness duration, hospitalized patients with AN benefit from gaining weight to a BMI ≥ 19 kg/m2.


2020 ◽  
Vol 16 (2) ◽  
pp. 92-98 ◽  
Author(s):  
Hana Tannir ◽  
Leila Itani ◽  
Dima Kreidieh ◽  
Dana El Masri ◽  
Samira Traboulsi ◽  
...  

Background: Anorexia nervosa is a serious health condition characterized by a significant low body weight and alteration in body composition components. Aim: In the current paper, we aim to summarize the available literature concerning changes in body fat, lean, and bone masses, during anorexia nervosa and after complete weight restoration. Methods: Data were summarized using a narrative approach based on clinical expertise in the interpretation of the available evidence base in the literature. Results: The available data revealed three main findings. Firstly, anorexia nervosa causes a significant reduction in body fat mass, however it is completely restored after short-term weight normalization but with a central adiposity phenotype that does not seem to negatively influence treatment outcomes and appears to normalize after 1 year of normal weight maintenance. Secondly, anorexia nervosa causes a significant reduction in bone mineral density, but weight restoration is associated first (≈12 months) with stabilization of bone mineral density, followed by improvements (after ≈16 months); and finally, with complete normalization (after ≈30 months) after normal-weight maintenance. Thirdly, during anorexia nervosa loss of lean and skeletal body mass occurring in particular from the extremities rather than the central regions has been consistently reported, especially in patients with a Body Mass Index (BMI) ≤ 16.5 Kg/m2 however short-term weight restoration is associated with complete normalization. Conclusion: Anorexia nervosa adversely affects body composition, however this medical complication seems to be reversible through the main treatment strategy of body weight restoration followed by normal weight maintenance, and this should be openly discussed with patients.


2018 ◽  
Vol 49 (09) ◽  
pp. 1555-1564 ◽  
Author(s):  
Nina von Schwanenflug ◽  
Dirk K. Müller ◽  
Joseph A. King ◽  
Franziska Ritschel ◽  
Fabio Bernardoni ◽  
...  

AbstractBackgroundGray matter (GM) ‘pseudoatrophy’ is well-documented in patients with anorexia nervosa (AN), but changes in white matter (WM) are less well understood. Here we investigated the dynamics of microstructural WM brain changes in AN patients during short-term weight restoration in a combined longitudinal and cross-sectional study design.MethodsDiffusion-weighted images were acquired in young AN patients before (acAN-Tp1, n = 56) and after (acAN-Tp2, n = 44) short-term weight restoration as well as in age-matched healthy controls (HC, n = 60). Images were processed using Tract-Based-Spatial-Statistics to compare fractional anisotropy (FA) across groups and timepoints.ResultsIn the cross-sectional comparison, FA was significantly reduced in the callosal body in acAN-Tp1 compared with HC, while no differences were found between acAN-Tp2 and HC. In the longitudinal arm, FA increased with weight gain in acAN-Tp2 relative to acAN-Tp1 in large parts of the callosal body and the fornix, while it decreased in the right corticospinal tract.ConclusionsOur findings reveal that dynamic, bidirectional changes in WM microstructure in young underweight patients with AN can be reversed with brief weight restoration therapy. These results parallel those previously observed in GM and suggest that alterations in WM in non-chronic AN are also state-dependent and rapidly reversible with successful intervention.


2001 ◽  
Vol 30 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Guido K. Frank ◽  
Walter H. Kaye ◽  
Theodore E. Weltzin ◽  
James Perel ◽  
Howard Moss ◽  
...  

1997 ◽  
Vol 2 (4) ◽  
pp. 330-334 ◽  
Author(s):  
J Hebebrand ◽  
W F Blum ◽  
N Barth ◽  
H Coners ◽  
P Englaro ◽  
...  

Author(s):  
Nina Schulz ◽  
Meriem Belheouane ◽  
Brigitte Dahmen ◽  
Vanessa A. Ruan ◽  
Hannah E. Specht ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Inger Hellerhoff ◽  
Joseph A. King ◽  
Friederike I. Tam ◽  
Sophie Pauligk ◽  
Maria Seidel ◽  
...  

AbstractAtrophic brain changes in acute anorexia nervosa (AN) are often visible to the naked eye on computed tomography or magnetic resonance imaging scans, but it remains unclear what is driving these effects. In neurological diseases, neurofilament light (NF-L) and tau protein have been linked to axonal damage. Glial fibrillary acidic protein (GFAP) has been associated with astroglial injury. In an attempt to shed new light on factors potentially underlying past findings of structural brain alterations in AN, the current study investigated serum NF-L, tau protein, and GFAP levels longitudinally in AN patients undergoing weight restoration. Blood samples were obtained from 54 acutely underweight, predominantly adolescent female AN patients and 54 age-matched healthy control participants. AN patients were studied in the severely underweight state and again after short-term partial weight restoration. Group comparisons revealed higher levels of NF-L, tau protein, and GFAP in acutely underweight patients with AN compared to healthy control participants. Longitudinally, a decrease in NF-L and GFAP but not in tau protein levels was observed in AN patients upon short-term partial weight restoration. These results may be indicative of ongoing neuronal and astroglial injury during the underweight phase of AN. Normalization of NF-L and GFAP but not tau protein levels may indicate an only partial restoration of neuronal and astroglial integrity upon weight gain after initial AN-associated cell damage processes.


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