Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study

Consumption of probiotics is known to influence the gut microbiota. The aim of this study was to assess the effect of probiotic powder containing Lactobacillus plantarum Dad-13 on bacterial composition in the gut by examining fecal samples of school-age children in Yogyakarta, Indonesia. This is a randomized, double-blind, placebo-controlled study. A total of 40 healthy subjects were recruited for this study and were divided into two groups: placebo group and probiotic group. The placebo group consumed skim milk and the probiotic group consumed probiotic powder containing L. plantarum Dad-13 (2 × 109 CFU/g) for 65 days. The results showed that placebo intake had no significant effect on gut microbiota; however, probiotic caused a significant increase in L. plantarum and Lactobacillus population, while decreasing the population of E. coli and non-E. coli coliform bacteria by 55% and 75%, respectively and Bifidobacteria count did not change significantly. The study concluded that consumption of probiotic powder L. plantarum Dad-13 could increase propionic acid thereby decreasing the gut pH which has an effect on the microbial population.

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A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression

Frontiers in Psychiatry ◽

10.3389/fpsyt.2012.00074 ◽

2012 ◽

Vol 3 ◽

Cited By ~ 79

Author(s):

Daniel M. Blumberger ◽

Lisa C. Tran ◽

Paul B. Fitzgerald ◽

Kate E. Hoy ◽

Zafiris J. Daskalakis

Keyword(s):

Major Depression ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Controlled Study ◽

Treatment Resistant ◽

Double Blind ◽

Direct Current Stimulation

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P.2.f.027 The efficacy and safety of basimglurant as adjunctive therapy in major depression; a randomised, double-blind, placebo-controlled study

European Neuropsychopharmacology ◽

10.1016/s0924-977x(14)70748-5 ◽

2014 ◽

Vol 24 ◽

pp. S468 ◽

Cited By ~ 12

Author(s):

J.A. Quiroz ◽

P. Tamburri ◽

D. Deptula ◽

L. Banken ◽

U. Beyer ◽

...

Keyword(s):

Major Depression ◽

Adjunctive Therapy ◽

Controlled Study ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo

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Efficacy and Safety of Single Intravenous Ketamine Infusion as an Add-on to Escitalopram in Major Depression: A Randomized, Double-blind, Placebo-controlled Study

Indian Journal of Private Psychiatry ◽

10.5005/jp-journals-10067-0041 ◽

2019 ◽

Vol 13 (2) ◽

pp. 31-36

Author(s):

Manu Sharma ◽

Shikha K Talati

Keyword(s):

Major Depression ◽

Controlled Study ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Ketamine Infusion ◽

Intravenous Ketamine

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A phase 2, double-blind, placeco-controlled study of the safety and efficacy of microbial ecosystem Therapeutic-2 (MET-2) in patients with major depression: Protocol and preliminary results

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.119742 ◽

2021 ◽

Vol 429 ◽

pp. 119742

Author(s):

Arthi Chinna Meyyappan ◽

Roumen Milev

Keyword(s):

Major Depression ◽

Controlled Study ◽

Phase 2 ◽

Double Blind ◽

Microbial Ecosystem ◽

Safety And Efficacy ◽

Preliminary Results

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Effects of Lactobacillus plantarum Q180 on Postprandial Lipid Levels and Intestinal Environment: A Double-Blind, Randomized, Placebo-Controlled, Parallel Trial

Nutrients ◽

10.3390/nu12010255 ◽

2020 ◽

Vol 12 (1) ◽

pp. 255 ◽

Cited By ~ 1

Author(s):

Ye Eun Park ◽

Min Seo Kim ◽

Kyung Won Shim ◽

You-Il Kim ◽

Jaeryang Chu ◽

...

Keyword(s):

Lactobacillus Plantarum ◽

Intestinal Microbiome ◽

Controlled Study ◽

Lipid Levels ◽

Double Blind ◽

Apo B ◽

Intestinal Environment ◽

Postprandial Lipid Metabolism ◽

Postprandial Lipid ◽

Underlying Mechanisms

Probiotics can improve the intestinal environment by enhancing beneficial bacteria to potentially regulate lipid levels; however, the underlying mechanisms remain unclear. The aim of this study was to investigate the effect of Lactobacillus plantarum Q180 (LPQ180) on postprandial lipid metabolism and the intestinal microbiome environment from a clinical perspective. A double-blind, randomized, placebo-controlled study was conducted including 70 participants of both sexes, 20 years of age and older, with healthy blood triacylglyceride (TG) levels below 200 mg/dL. Treatment with LPQ180 for 12 weeks significantly decreased LDL-cholesterol (p = 0.042) and apolipoprotein (Apo)B-100 (p = 0.003) levels, and decreased postprandial maximum concentrations (Cmax) and areas under the curve (AUC) of TG, chylomicron TG, ApoB-48, and ApoB-100. LPQ180 treatment significantly decreased total indole and phenol levels (p = 0.019). In addition, there was a negative correlation between baseline microbiota abundance and lipid marker change, which was negatively correlated with metabolites. This study suggests that LPQ180 might be developed as a functional ingredient to help maintain healthy postprandial lipid levels through modulating gut environment.

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