Parvocellular pathway impairment in autism spectrum disorder: Evidence from visual evoked potentials

RESUMO Objetivo Identificar e analisar quais são os achados característicos dos Potenciais Evocados Auditivos Corticais (PEAC) em crianças e/ou adolescentes com Transtorno do Espectro do Autismo (TEA) em comparação do desenvolvimento típico, por meio de uma revisão sistemática da literatura. Estratégia de pesquisa Após formulação da pergunta de pesquisa, foi realizada uma revisão da literatura em sete bases de dados (Web of Science, Pubmed, Cochrane Library, Lilacs, Scielo, Science Direct, e Google acadêmico), com os seguintes descritores: transtorno do espectro autista (autism spectrum disorder), transtorno autístico (autistic disorder), potenciais evocados auditivos (evoked potentials, auditory), potencial evocado P300 (event related potentials, P300) e criança (child). A presente revisão foi cadastrada no Próspero, sob número 118751. Critérios de seleção Foram selecionados estudos publicados na integra, sem limitação de idioma, entre 2007 e 2019. Análise dos dados: Foram analisadas as características de latência e amplitude dos componentes P1, N1, P2, N2 e P3 presentes nos PEAC. Resultados Foram localizados 193 estudos; contudo 15 estudos contemplaram os critérios de inclusão. Embora não tenha sido possível identificar um padrão de resposta para os componentes P1, N1, P2, N2 e P3, os resultados da maioria dos estudos demonstraram que indivíduos com TEA podem apresentar diminuição de amplitude e aumento de latência do componente P3. Conclusão Indivíduos com TEA podem apresentar respostas diversas para os componentes dos PEAC, sendo que a diminuição de amplitude e aumento de latência do componente P3 foram as características mais comuns.

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Brainstem auditory evoked potentials in children with autism spectrum disorder

Jornal de Pediatria ◽

10.1016/j.jped.2018.12.010 ◽

2020 ◽

Vol 96 (3) ◽

pp. 386-392

Author(s):

Mariana Keiko Kamita ◽

Liliane Aparecida Fagundes Silva ◽

Fernanda Cristina Leite Magliaro ◽

Rebeca Yuko Couto Kawai ◽

Fernanda Dreux Miranda Fernandes ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Children With Autism ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Brainstem Auditory Evoked Potentials

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Characteristic Deviations of Auditory Evoked Potentials in Individuals with Autism Spectrum Disorder

Journal of the American Academy of Audiology ◽

10.1055/s-0041-1730365 ◽

2021 ◽

Vol 32 (06) ◽

pp. 379-385

Author(s):

Kamakshi V. Gopal ◽

Erin C. Schafer ◽

Rajesh Nandy ◽

Ashley Brown ◽

Joshua Caldwell ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Auditory Training ◽

Control Group ◽

Control Groups ◽

And Control ◽

Adults With Asd

Abstract Background Neurological, structural, and behavioral abnormalities are widely reported in individuals with autism spectrum disorder (ASD); yet there are no objective markers to date. We postulated that by using dominant and nondominant ear data, underlying differences in auditory evoked potentials (AEPs) between ASD and control groups can be recognized. Purpose The primary purpose was to identify if significant differences exist in AEPs recorded from dominant and nondominant ear stimulation in (1) children with ASD and their matched controls, (2) adults with ASD and their matched controls, and (3) a combined child and adult ASD group and control group. The secondary purpose was to explore the association between the significant findings of this study with those obtained in our previous study that evaluated the effects of auditory training on AEPs in individuals with ASD. Research Design Factorial analysis of variance with interaction was performed. Study Sample Forty subjects with normal hearing between the ages of 9 and 25 years were included. Eleven children and 9 adults with ASD were age- and gender-matched with neurotypical peers. Data Collection and Analysis Auditory brainstem responses (ABRs) and auditory late responses (ALRs) were recorded. Adult and child ASD subjects were compared with non-ASD adult and child control subjects, respectively. The combined child and adult ASD group was compared with the combined child and adult control group. Results No significant differences in ABR latency or amplitude were observed between ASD and control groups. ALR N1 amplitude in the dominant ear was significantly smaller for the ASD adult group compared with their control group. Combined child and adult data showed significantly smaller amplitude for ALR N1 and longer ALR P2 latency in the dominant ear for the ASD group compared with the control group. In our earlier study, the top predictor of behavioral improvement following auditory training was ALR N1 amplitude in the dominant ear. Correspondingly, the ALR N1 amplitude in the dominant ear yielded group differences in the current study. Conclusions ALR peak N1 amplitude is proposed as the most feasible AEP marker in the evaluation of ASD.

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Artifact Removal of Visual Evoked Potentials in Autism Spectrum Disorders

10.1007/978-981-16-5120-5_17 ◽

2021 ◽

pp. 213-226

Author(s):

Subha D. Puthankattil ◽

Priyalakshmi Sheela

Keyword(s):

Autism Spectrum Disorders ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Autism Spectrum ◽

Artifact Removal ◽

Spectrum Disorders ◽

Visual Evoked

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Comparison of Visual Evoked Potentials in Patients Affected by Optic Neuritis From Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder

Journal of Neuro-Ophthalmology ◽

10.1097/wno.0000000000001285 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Thiago G. Filgueiras ◽

Maria K. Oyamada ◽

Kenzo Hokazono ◽

Leonardo P. Cunha ◽

Samira L. Apóstolos-Pereira ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Neuritis ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

Neuromyelitis Optica ◽

Spectrum Disorder ◽

Neuromyelitis Optica Spectrum Disorder ◽

Visual Evoked

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Reduced visual evoked potential amplitude in autism spectrum disorder, a variability effect?

Translational Psychiatry ◽

10.1038/s41398-019-0672-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 5

Author(s):

Klara Kovarski ◽

Joëlle Malvy ◽

Raoul K. Khanna ◽

Sophie Arsène ◽

Magali Batty ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Visual Processing ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Pattern Reversal ◽

Single Trial ◽

Neural Noise ◽

Children With Asd ◽

Latency Range ◽

Visual Evoked

AbstractAtypical sensory behaviours represent a core symptom of autism spectrum disorder (ASD). Investigating early visual processing is crucial to deepen our understanding of higher-level processes. Visual evoked potentials (VEPs) to pattern-reversal checkerboards were recorded in ASD children and age-matched controls. Peak analysis of the P100 component and two types of single-trial analyses were carried out. P100 amplitude was reduced in the ASD group, consistent with previous reports. The analysis of the proportion of trials with a positive activity in the latency range of the P100, measuring inter-trial (in)consistency, allowed identifying two subgroups of ASD participants: the first group, as control children, showed a high inter-trial consistency, whereas the other group showed an inter-trial inconsistency. Analysis of median absolute deviation of single-trial P100 (st-P100) latencies revealed an increased latency variability in the ASD group. Both single-trial analyses revealed increased variability in a subset of children with ASD. To control for this variability, VEPs were reconstructed by including only positive trials or trials with homogeneous st-P100 latencies. These control analyses abolished group differences, confirming that the reduced P100 amplitude results from increased inter-trial variability in ASD. This increased variability in ASD supports the neural noise theory. The existence of subgroups in ASD suggests that the neural response variability is not a genuine characteristic of the entire autistic spectrum, but rather characterized subgroups of children. Exploring the relationship between sensory responsiveness and inter-trial variability could provide more precise bioclinical profiles in children with ASD, and complete the functional diagnostic crucial for the development of individualized therapeutical projects.

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